Lethal effect of oxamniquine and praziquantel on mice experimentally infected with Schistosoma mansoni Efeito letal de oxamniquina e praziquantel em camundongos experimentalmente infectados com Schistosoma mansoni
Lethality caused by administration of oxamniquine and praziquantel to mice infected with Schistosoma mansoni, and their respective controls (uninfected), has been studied. As the results indicate, the infected animals clearly showed higher mortality rates when praziquantel was used. Surprisingly, it...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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Universidade de São Paulo (USP)
1995
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Online Access: | https://doi.org/10.1590/S0036-46651995000400014 https://doaj.org/article/88630848689c4f29ba49e77cf7a64c58 |
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ftdoajarticles:oai:doaj.org/article:88630848689c4f29ba49e77cf7a64c58 2024-09-09T19:26:12+00:00 Lethal effect of oxamniquine and praziquantel on mice experimentally infected with Schistosoma mansoni Efeito letal de oxamniquina e praziquantel em camundongos experimentalmente infectados com Schistosoma mansoni Sonia Maria A.F. Tonelli Eugênio M.A. Goulart Edward Tonelli Paulo Marcos Zech Coelho 1995-08-01T00:00:00Z https://doi.org/10.1590/S0036-46651995000400014 https://doaj.org/article/88630848689c4f29ba49e77cf7a64c58 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651995000400014 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651995000400014 0036-4665 1678-9946 https://doaj.org/article/88630848689c4f29ba49e77cf7a64c58 Revista do Instituto de Medicina Tropical de São Paulo, Vol 37, Iss 4, Pp 361-363 (1995) Schistosoma mansoni LD50 Oxamniquine Praziquantel Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1995 ftdoajarticles https://doi.org/10.1590/S0036-46651995000400014 2024-08-05T17:49:31Z Lethality caused by administration of oxamniquine and praziquantel to mice infected with Schistosoma mansoni, and their respective controls (uninfected), has been studied. As the results indicate, the infected animals clearly showed higher mortality rates when praziquantel was used. Surprisingly, it may be noted that exactly the contrary occurs in relation to the use of oxamniquine, inasmuch as marked higher mortality rates were seen in the control animals (uninfected). These observations lead to the conclusion that further toxicological studies of antischistosomal drugs using. S. mansoni infected animals are needed. Pesquisou-se a letalidade causada por administração de drogas (oxamniquina e praziquantel) em camundongos infectados por Schistosoma mansoni e seus respectivos controles não infectados. Os resultados indicam que os animais infectados apresentam claramente taxas de mortalidade mais altas, quando foi utilizado o praziquantel. Surpreendentemente, o contrário aconteceu com relação ao uso da oxamniquina, uma vez que taxas de mortalidade marcantemente mais altas puderam ser detectadas nos animais controles (não infectados). Estas observações levam à conclusão de que são necessários mais estudos toxicológicos sobre drogas esquistossomicidas, usandose animais infectados com S. mansoni. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 37 4 361 363 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Schistosoma mansoni LD50 Oxamniquine Praziquantel Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Schistosoma mansoni LD50 Oxamniquine Praziquantel Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Sonia Maria A.F. Tonelli Eugênio M.A. Goulart Edward Tonelli Paulo Marcos Zech Coelho Lethal effect of oxamniquine and praziquantel on mice experimentally infected with Schistosoma mansoni Efeito letal de oxamniquina e praziquantel em camundongos experimentalmente infectados com Schistosoma mansoni |
topic_facet |
Schistosoma mansoni LD50 Oxamniquine Praziquantel Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Lethality caused by administration of oxamniquine and praziquantel to mice infected with Schistosoma mansoni, and their respective controls (uninfected), has been studied. As the results indicate, the infected animals clearly showed higher mortality rates when praziquantel was used. Surprisingly, it may be noted that exactly the contrary occurs in relation to the use of oxamniquine, inasmuch as marked higher mortality rates were seen in the control animals (uninfected). These observations lead to the conclusion that further toxicological studies of antischistosomal drugs using. S. mansoni infected animals are needed. Pesquisou-se a letalidade causada por administração de drogas (oxamniquina e praziquantel) em camundongos infectados por Schistosoma mansoni e seus respectivos controles não infectados. Os resultados indicam que os animais infectados apresentam claramente taxas de mortalidade mais altas, quando foi utilizado o praziquantel. Surpreendentemente, o contrário aconteceu com relação ao uso da oxamniquina, uma vez que taxas de mortalidade marcantemente mais altas puderam ser detectadas nos animais controles (não infectados). Estas observações levam à conclusão de que são necessários mais estudos toxicológicos sobre drogas esquistossomicidas, usandose animais infectados com S. mansoni. |
format |
Article in Journal/Newspaper |
author |
Sonia Maria A.F. Tonelli Eugênio M.A. Goulart Edward Tonelli Paulo Marcos Zech Coelho |
author_facet |
Sonia Maria A.F. Tonelli Eugênio M.A. Goulart Edward Tonelli Paulo Marcos Zech Coelho |
author_sort |
Sonia Maria A.F. Tonelli |
title |
Lethal effect of oxamniquine and praziquantel on mice experimentally infected with Schistosoma mansoni Efeito letal de oxamniquina e praziquantel em camundongos experimentalmente infectados com Schistosoma mansoni |
title_short |
Lethal effect of oxamniquine and praziquantel on mice experimentally infected with Schistosoma mansoni Efeito letal de oxamniquina e praziquantel em camundongos experimentalmente infectados com Schistosoma mansoni |
title_full |
Lethal effect of oxamniquine and praziquantel on mice experimentally infected with Schistosoma mansoni Efeito letal de oxamniquina e praziquantel em camundongos experimentalmente infectados com Schistosoma mansoni |
title_fullStr |
Lethal effect of oxamniquine and praziquantel on mice experimentally infected with Schistosoma mansoni Efeito letal de oxamniquina e praziquantel em camundongos experimentalmente infectados com Schistosoma mansoni |
title_full_unstemmed |
Lethal effect of oxamniquine and praziquantel on mice experimentally infected with Schistosoma mansoni Efeito letal de oxamniquina e praziquantel em camundongos experimentalmente infectados com Schistosoma mansoni |
title_sort |
lethal effect of oxamniquine and praziquantel on mice experimentally infected with schistosoma mansoni efeito letal de oxamniquina e praziquantel em camundongos experimentalmente infectados com schistosoma mansoni |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1995 |
url |
https://doi.org/10.1590/S0036-46651995000400014 https://doaj.org/article/88630848689c4f29ba49e77cf7a64c58 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 37, Iss 4, Pp 361-363 (1995) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651995000400014 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651995000400014 0036-4665 1678-9946 https://doaj.org/article/88630848689c4f29ba49e77cf7a64c58 |
op_doi |
https://doi.org/10.1590/S0036-46651995000400014 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
container_volume |
37 |
container_issue |
4 |
container_start_page |
361 |
op_container_end_page |
363 |
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