Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria
Abstract Quinine remains an important anti-malarial drug almost 400 years after its effectiveness was first documented. However, its continued use is challenged by its poor tolerability, poor compliance with complex dosing regimens, and the availability of more efficacious anti-malarial drugs. This...
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ftdoajarticles:oai:doaj.org/article:8857fd9d84de4c7197f3cae40e0b3893 2023-05-15T15:10:48+02:00 Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria Baliraine Frederick N Tibenderana James K Yeka Adoke Erhart Annette Talisuna Ambrose O Achan Jane Rosenthal Philip J D'Alessandro Umberto 2011-05-01T00:00:00Z https://doi.org/10.1186/1475-2875-10-144 https://doaj.org/article/8857fd9d84de4c7197f3cae40e0b3893 EN eng BMC http://www.malariajournal.com/content/10/1/144 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-144 1475-2875 https://doaj.org/article/8857fd9d84de4c7197f3cae40e0b3893 Malaria Journal, Vol 10, Iss 1, p 144 (2011) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2011 ftdoajarticles https://doi.org/10.1186/1475-2875-10-144 2022-12-31T00:29:53Z Abstract Quinine remains an important anti-malarial drug almost 400 years after its effectiveness was first documented. However, its continued use is challenged by its poor tolerability, poor compliance with complex dosing regimens, and the availability of more efficacious anti-malarial drugs. This article reviews the historical role of quinine, considers its current usage and provides insight into its appropriate future use in the treatment of malaria. In light of recent research findings intravenous artesunate should be the first-line drug for severe malaria, with quinine as an alternative. The role of rectal quinine as pre-referral treatment for severe malaria has not been fully explored, but it remains a promising intervention. In pregnancy, quinine continues to play a critical role in the management of malaria, especially in the first trimester, and it will remain a mainstay of treatment until safer alternatives become available. For uncomplicated malaria, artemisinin-based combination therapy (ACT) offers a better option than quinine though the difficulty of maintaining a steady supply of ACT in resource-limited settings renders the rapid withdrawal of quinine for uncomplicated malaria cases risky. The best approach would be to identify solutions to ACT stock-outs, maintain quinine in case of ACT stock-outs, and evaluate strategies for improving quinine treatment outcomes by combining it with antibiotics. In HIV and TB infected populations, concerns about potential interactions between quinine and antiretroviral and anti-tuberculosis drugs exist, and these will need further research and pharmacovigilance. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 10 1 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Baliraine Frederick N Tibenderana James K Yeka Adoke Erhart Annette Talisuna Ambrose O Achan Jane Rosenthal Philip J D'Alessandro Umberto Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Quinine remains an important anti-malarial drug almost 400 years after its effectiveness was first documented. However, its continued use is challenged by its poor tolerability, poor compliance with complex dosing regimens, and the availability of more efficacious anti-malarial drugs. This article reviews the historical role of quinine, considers its current usage and provides insight into its appropriate future use in the treatment of malaria. In light of recent research findings intravenous artesunate should be the first-line drug for severe malaria, with quinine as an alternative. The role of rectal quinine as pre-referral treatment for severe malaria has not been fully explored, but it remains a promising intervention. In pregnancy, quinine continues to play a critical role in the management of malaria, especially in the first trimester, and it will remain a mainstay of treatment until safer alternatives become available. For uncomplicated malaria, artemisinin-based combination therapy (ACT) offers a better option than quinine though the difficulty of maintaining a steady supply of ACT in resource-limited settings renders the rapid withdrawal of quinine for uncomplicated malaria cases risky. The best approach would be to identify solutions to ACT stock-outs, maintain quinine in case of ACT stock-outs, and evaluate strategies for improving quinine treatment outcomes by combining it with antibiotics. In HIV and TB infected populations, concerns about potential interactions between quinine and antiretroviral and anti-tuberculosis drugs exist, and these will need further research and pharmacovigilance. |
format |
Article in Journal/Newspaper |
author |
Baliraine Frederick N Tibenderana James K Yeka Adoke Erhart Annette Talisuna Ambrose O Achan Jane Rosenthal Philip J D'Alessandro Umberto |
author_facet |
Baliraine Frederick N Tibenderana James K Yeka Adoke Erhart Annette Talisuna Ambrose O Achan Jane Rosenthal Philip J D'Alessandro Umberto |
author_sort |
Baliraine Frederick N |
title |
Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria |
title_short |
Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria |
title_full |
Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria |
title_fullStr |
Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria |
title_full_unstemmed |
Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria |
title_sort |
quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria |
publisher |
BMC |
publishDate |
2011 |
url |
https://doi.org/10.1186/1475-2875-10-144 https://doaj.org/article/8857fd9d84de4c7197f3cae40e0b3893 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 10, Iss 1, p 144 (2011) |
op_relation |
http://www.malariajournal.com/content/10/1/144 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-144 1475-2875 https://doaj.org/article/8857fd9d84de4c7197f3cae40e0b3893 |
op_doi |
https://doi.org/10.1186/1475-2875-10-144 |
container_title |
Malaria Journal |
container_volume |
10 |
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1 |
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1766341754205765632 |