Optimal control of malaria: combining vector interventions and drug therapies
Abstract Background The sterile insect technique and transgenic equivalents are considered promising tools for controlling vector-borne disease in an age of increasing insecticide and drug-resistance. Combining vector interventions with artemisinin-based therapies may achieve the twin goals of suppr...
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ftdoajarticles:oai:doaj.org/article:880dbe698aa544e584dcc5034205630c 2023-05-15T15:07:03+02:00 Optimal control of malaria: combining vector interventions and drug therapies Doran Khamis Claire El Mouden Klodeta Kura Michael B. Bonsall 2018-04-01T00:00:00Z https://doi.org/10.1186/s12936-018-2321-6 https://doaj.org/article/880dbe698aa544e584dcc5034205630c EN eng BMC http://link.springer.com/article/10.1186/s12936-018-2321-6 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-018-2321-6 1475-2875 https://doaj.org/article/880dbe698aa544e584dcc5034205630c Malaria Journal, Vol 17, Iss 1, Pp 1-18 (2018) Vector control Optimal control Cost-effectiveness Malaria management Artemisinin ACT Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2018 ftdoajarticles https://doi.org/10.1186/s12936-018-2321-6 2022-12-31T06:20:49Z Abstract Background The sterile insect technique and transgenic equivalents are considered promising tools for controlling vector-borne disease in an age of increasing insecticide and drug-resistance. Combining vector interventions with artemisinin-based therapies may achieve the twin goals of suppressing malaria endemicity while managing artemisinin resistance. While the cost-effectiveness of these controls has been investigated independently, their combined usage has not been dynamically optimized in response to ecological and epidemiological processes. Results An optimal control framework based on coupled models of mosquito population dynamics and malaria epidemiology is used to investigate the cost-effectiveness of combining vector control with drug therapies in homogeneous environments with and without vector migration. The costs of endemic malaria are weighed against the costs of administering artemisinin therapies and releasing modified mosquitoes using various cost structures. Larval density dependence is shown to reduce the cost-effectiveness of conventional sterile insect releases compared with transgenic mosquitoes with a late-acting lethal gene. Using drug treatments can reduce the critical vector control release ratio necessary to cause disease fadeout. Conclusions Combining vector control and drug therapies is the most effective and efficient use of resources, and using optimized implementation strategies can substantially reduce costs. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 17 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Vector control Optimal control Cost-effectiveness Malaria management Artemisinin ACT Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Vector control Optimal control Cost-effectiveness Malaria management Artemisinin ACT Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Doran Khamis Claire El Mouden Klodeta Kura Michael B. Bonsall Optimal control of malaria: combining vector interventions and drug therapies |
topic_facet |
Vector control Optimal control Cost-effectiveness Malaria management Artemisinin ACT Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The sterile insect technique and transgenic equivalents are considered promising tools for controlling vector-borne disease in an age of increasing insecticide and drug-resistance. Combining vector interventions with artemisinin-based therapies may achieve the twin goals of suppressing malaria endemicity while managing artemisinin resistance. While the cost-effectiveness of these controls has been investigated independently, their combined usage has not been dynamically optimized in response to ecological and epidemiological processes. Results An optimal control framework based on coupled models of mosquito population dynamics and malaria epidemiology is used to investigate the cost-effectiveness of combining vector control with drug therapies in homogeneous environments with and without vector migration. The costs of endemic malaria are weighed against the costs of administering artemisinin therapies and releasing modified mosquitoes using various cost structures. Larval density dependence is shown to reduce the cost-effectiveness of conventional sterile insect releases compared with transgenic mosquitoes with a late-acting lethal gene. Using drug treatments can reduce the critical vector control release ratio necessary to cause disease fadeout. Conclusions Combining vector control and drug therapies is the most effective and efficient use of resources, and using optimized implementation strategies can substantially reduce costs. |
format |
Article in Journal/Newspaper |
author |
Doran Khamis Claire El Mouden Klodeta Kura Michael B. Bonsall |
author_facet |
Doran Khamis Claire El Mouden Klodeta Kura Michael B. Bonsall |
author_sort |
Doran Khamis |
title |
Optimal control of malaria: combining vector interventions and drug therapies |
title_short |
Optimal control of malaria: combining vector interventions and drug therapies |
title_full |
Optimal control of malaria: combining vector interventions and drug therapies |
title_fullStr |
Optimal control of malaria: combining vector interventions and drug therapies |
title_full_unstemmed |
Optimal control of malaria: combining vector interventions and drug therapies |
title_sort |
optimal control of malaria: combining vector interventions and drug therapies |
publisher |
BMC |
publishDate |
2018 |
url |
https://doi.org/10.1186/s12936-018-2321-6 https://doaj.org/article/880dbe698aa544e584dcc5034205630c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 17, Iss 1, Pp 1-18 (2018) |
op_relation |
http://link.springer.com/article/10.1186/s12936-018-2321-6 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-018-2321-6 1475-2875 https://doaj.org/article/880dbe698aa544e584dcc5034205630c |
op_doi |
https://doi.org/10.1186/s12936-018-2321-6 |
container_title |
Malaria Journal |
container_volume |
17 |
container_issue |
1 |
_version_ |
1766338625524465664 |