Human papillomavirus types in cervical high‐grade lesions or cancer among Nordic women—Potential for prevention
Abstract It is valuable to establish a population‐based prevaccination baseline distribution of human papillomavirus (HPV) types among women with high‐grade cervical intraepithelial neoplasia (CIN) grade 2 or 3 and cervical cancer in order to assess the potential impact of HPV vaccination. In four c...
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ftdoajarticles:oai:doaj.org/article:876c6341eeab4b5b81524e5459eb6a51 2023-07-30T04:04:28+02:00 Human papillomavirus types in cervical high‐grade lesions or cancer among Nordic women—Potential for prevention Cecilie Dovey de la Cour Sonia Guleria Mari Nygård Laufey Trygvadóttir Kristjan Sigurdsson Kai‐Li Liaw Maria Hortlund Camilla Lagheden Bo T. Hansen Christian Munk Joakim Dillner Susanne K. Kjaer 2019-02-01T00:00:00Z https://doi.org/10.1002/cam4.1961 https://doaj.org/article/876c6341eeab4b5b81524e5459eb6a51 EN eng Wiley https://doi.org/10.1002/cam4.1961 https://doaj.org/toc/2045-7634 2045-7634 doi:10.1002/cam4.1961 https://doaj.org/article/876c6341eeab4b5b81524e5459eb6a51 Cancer Medicine, Vol 8, Iss 2, Pp 839-849 (2019) cervical cancer cervical intraepithelial neoplasia human papillomavirus nordic countries prevalence Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 article 2019 ftdoajarticles https://doi.org/10.1002/cam4.1961 2023-07-16T00:35:27Z Abstract It is valuable to establish a population‐based prevaccination baseline distribution of human papillomavirus (HPV) types among women with high‐grade cervical intraepithelial neoplasia (CIN) grade 2 or 3 and cervical cancer in order to assess the potential impact of HPV vaccination. In four countries (Denmark, Norway, Sweden, and Iceland), we collected consecutive series of cervical cancers (n = 639) and high‐grade precancerous cervical lesions (n = 1240) during 2004‐2006 before implementation of HPV vaccination and subjected the specimens to standardized HPV genotyping. The HPV prevalence was 82.7% (95% confidence interval [CI] 79.0‐86.4) in CIN2, 91.6% (95% CI 89.7‐93.5) in CIN3, and 86.4% (95% CI 83.7‐89.1) in cervical cancer. The most common HPV types in CIN2/3 were HPV16 (CIN2: 35.9%, 95% CI 31.2‐40.6; CIN3: 50.2%, 95% CI 46.8‐53.6) and HPV31 (CIN2: 10.9%, 95% CI 7.8‐13.9; CIN3: 12.1%, 95% CI 9.9‐14.3), while HPV16 and HPV18 were the most frequent types in cervical cancer (48.8%, 95% CI 44.9‐52.7 and 15.3%, 95% CI 12.5‐18.1, respectively). The prevalence of HPV16/18 decreased with increasing age at diagnosis in both CIN2/3 and cervical cancer (P < 0.0001). Elimination of HPV16/18 by vaccination is predicted to prevent 42% (95% CI 37.0‐46.7) of CIN2, 57% (95% CI 53.8‐60.5) of CIN3 and 64% (95% CI 60.3‐67.7) of cervical cancer. Prevention of the five additional HPV types HPV31/33/45/52/58 would increase the protection to 68% (95% CI 63.0‐72.2) in CIN2, 85% (95% CI 82.4‐87.2) in CIN3 and 80% (95% CI 77.0‐83.2) in cervical cancer. This study provides large‐scale and representative baselines for assessing and evaluating the population‐based preventive impact of HPV vaccination. Article in Journal/Newspaper Iceland Directory of Open Access Journals: DOAJ Articles Norway Cancer Medicine 8 2 839 849 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
cervical cancer cervical intraepithelial neoplasia human papillomavirus nordic countries prevalence Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
spellingShingle |
cervical cancer cervical intraepithelial neoplasia human papillomavirus nordic countries prevalence Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cecilie Dovey de la Cour Sonia Guleria Mari Nygård Laufey Trygvadóttir Kristjan Sigurdsson Kai‐Li Liaw Maria Hortlund Camilla Lagheden Bo T. Hansen Christian Munk Joakim Dillner Susanne K. Kjaer Human papillomavirus types in cervical high‐grade lesions or cancer among Nordic women—Potential for prevention |
topic_facet |
cervical cancer cervical intraepithelial neoplasia human papillomavirus nordic countries prevalence Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
description |
Abstract It is valuable to establish a population‐based prevaccination baseline distribution of human papillomavirus (HPV) types among women with high‐grade cervical intraepithelial neoplasia (CIN) grade 2 or 3 and cervical cancer in order to assess the potential impact of HPV vaccination. In four countries (Denmark, Norway, Sweden, and Iceland), we collected consecutive series of cervical cancers (n = 639) and high‐grade precancerous cervical lesions (n = 1240) during 2004‐2006 before implementation of HPV vaccination and subjected the specimens to standardized HPV genotyping. The HPV prevalence was 82.7% (95% confidence interval [CI] 79.0‐86.4) in CIN2, 91.6% (95% CI 89.7‐93.5) in CIN3, and 86.4% (95% CI 83.7‐89.1) in cervical cancer. The most common HPV types in CIN2/3 were HPV16 (CIN2: 35.9%, 95% CI 31.2‐40.6; CIN3: 50.2%, 95% CI 46.8‐53.6) and HPV31 (CIN2: 10.9%, 95% CI 7.8‐13.9; CIN3: 12.1%, 95% CI 9.9‐14.3), while HPV16 and HPV18 were the most frequent types in cervical cancer (48.8%, 95% CI 44.9‐52.7 and 15.3%, 95% CI 12.5‐18.1, respectively). The prevalence of HPV16/18 decreased with increasing age at diagnosis in both CIN2/3 and cervical cancer (P < 0.0001). Elimination of HPV16/18 by vaccination is predicted to prevent 42% (95% CI 37.0‐46.7) of CIN2, 57% (95% CI 53.8‐60.5) of CIN3 and 64% (95% CI 60.3‐67.7) of cervical cancer. Prevention of the five additional HPV types HPV31/33/45/52/58 would increase the protection to 68% (95% CI 63.0‐72.2) in CIN2, 85% (95% CI 82.4‐87.2) in CIN3 and 80% (95% CI 77.0‐83.2) in cervical cancer. This study provides large‐scale and representative baselines for assessing and evaluating the population‐based preventive impact of HPV vaccination. |
format |
Article in Journal/Newspaper |
author |
Cecilie Dovey de la Cour Sonia Guleria Mari Nygård Laufey Trygvadóttir Kristjan Sigurdsson Kai‐Li Liaw Maria Hortlund Camilla Lagheden Bo T. Hansen Christian Munk Joakim Dillner Susanne K. Kjaer |
author_facet |
Cecilie Dovey de la Cour Sonia Guleria Mari Nygård Laufey Trygvadóttir Kristjan Sigurdsson Kai‐Li Liaw Maria Hortlund Camilla Lagheden Bo T. Hansen Christian Munk Joakim Dillner Susanne K. Kjaer |
author_sort |
Cecilie Dovey de la Cour |
title |
Human papillomavirus types in cervical high‐grade lesions or cancer among Nordic women—Potential for prevention |
title_short |
Human papillomavirus types in cervical high‐grade lesions or cancer among Nordic women—Potential for prevention |
title_full |
Human papillomavirus types in cervical high‐grade lesions or cancer among Nordic women—Potential for prevention |
title_fullStr |
Human papillomavirus types in cervical high‐grade lesions or cancer among Nordic women—Potential for prevention |
title_full_unstemmed |
Human papillomavirus types in cervical high‐grade lesions or cancer among Nordic women—Potential for prevention |
title_sort |
human papillomavirus types in cervical high‐grade lesions or cancer among nordic women—potential for prevention |
publisher |
Wiley |
publishDate |
2019 |
url |
https://doi.org/10.1002/cam4.1961 https://doaj.org/article/876c6341eeab4b5b81524e5459eb6a51 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Cancer Medicine, Vol 8, Iss 2, Pp 839-849 (2019) |
op_relation |
https://doi.org/10.1002/cam4.1961 https://doaj.org/toc/2045-7634 2045-7634 doi:10.1002/cam4.1961 https://doaj.org/article/876c6341eeab4b5b81524e5459eb6a51 |
op_doi |
https://doi.org/10.1002/cam4.1961 |
container_title |
Cancer Medicine |
container_volume |
8 |
container_issue |
2 |
container_start_page |
839 |
op_container_end_page |
849 |
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1772815939484516352 |