Dynamics of Plasmodium vivax populations in border areas of the Greater Mekong sub-region during malaria elimination
Abstract Background Countries within the Greater Mekong Sub-region (GMS) of Southeast Asia have committed to eliminating malaria by 2030. Although the malaria situation has greatly improved, malaria transmission remains at international border regions. In some areas, Plasmodium vivax has become the...
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ftdoajarticles:oai:doaj.org/article:8732953d7ea64ad49f6a75c429a673bc 2023-05-15T15:18:21+02:00 Dynamics of Plasmodium vivax populations in border areas of the Greater Mekong sub-region during malaria elimination Yuling Li Yubing Hu Yan Zhao Qinghui Wang Huguette Gaelle Ngassa Mbenda Veerayuth Kittichai Saranath Lawpoolsri Jetsumon Sattabongkot Lynette Menezes Xiaoming Liu Liwang Cui Yaming Cao 2020-04-01T00:00:00Z https://doi.org/10.1186/s12936-020-03221-9 https://doaj.org/article/8732953d7ea64ad49f6a75c429a673bc EN eng BMC http://link.springer.com/article/10.1186/s12936-020-03221-9 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-03221-9 1475-2875 https://doaj.org/article/8732953d7ea64ad49f6a75c429a673bc Malaria Journal, Vol 19, Iss 1, Pp 1-12 (2020) Malaria Plasmodium vivax Epidemiology Population genetics Microsatellites Greater Mekong sub-region Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2020 ftdoajarticles https://doi.org/10.1186/s12936-020-03221-9 2022-12-31T16:30:10Z Abstract Background Countries within the Greater Mekong Sub-region (GMS) of Southeast Asia have committed to eliminating malaria by 2030. Although the malaria situation has greatly improved, malaria transmission remains at international border regions. In some areas, Plasmodium vivax has become the predominant parasite. To gain a better understanding of transmission dynamics, knowledge on the changes of P. vivax populations after the scale-up of control interventions will guide more effective targeted control efforts. Methods This study investigated genetic diversity and population structures in 206 P. vivax clinical samples collected at two time points in two international border areas: the China-Myanmar border (CMB) (n = 50 in 2004 and n = 52 in 2016) and Thailand-Myanmar border (TMB) (n = 50 in 2012 and n = 54 in 2015). Parasites were genotyped using 10 microsatellite markers. Results Despite intensified control efforts, genetic diversity remained high (H E = 0.66–0.86) and was not significantly different among the four populations (P > 0.05). Specifically, H E slightly decreased from 0.76 in 2004 to 0.66 in 2016 at the CMB and increased from 0.80 in 2012 to 0.86 in 2015 at the TMB. The proportions of polyclonal infections varied significantly among the four populations (P < 0.05), and showed substantial decreases from 48.0% in 2004 to 23.7 at the CMB and from 40.0% in 2012 to 30.7% in 2015 at the TMB, with corresponding decreases in the multiplicity of infection. Consistent with the continuous decline of malaria incidence in the GMS over time, there were also increases in multilocus linkage disequilibrium, suggesting more fragmented and increasingly inbred parasite populations. There were considerable genetic differentiation and sub-division among the four tested populations. Temporal genetic differentiation was observed at each site (F ST = 0.081 at the CMB and F ST = 0.133 at the TMB). Various degrees of clustering were evident between the older parasite samples collected in 2004 at the CMB and the ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 19 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Malaria Plasmodium vivax Epidemiology Population genetics Microsatellites Greater Mekong sub-region Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria Plasmodium vivax Epidemiology Population genetics Microsatellites Greater Mekong sub-region Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Yuling Li Yubing Hu Yan Zhao Qinghui Wang Huguette Gaelle Ngassa Mbenda Veerayuth Kittichai Saranath Lawpoolsri Jetsumon Sattabongkot Lynette Menezes Xiaoming Liu Liwang Cui Yaming Cao Dynamics of Plasmodium vivax populations in border areas of the Greater Mekong sub-region during malaria elimination |
topic_facet |
Malaria Plasmodium vivax Epidemiology Population genetics Microsatellites Greater Mekong sub-region Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Countries within the Greater Mekong Sub-region (GMS) of Southeast Asia have committed to eliminating malaria by 2030. Although the malaria situation has greatly improved, malaria transmission remains at international border regions. In some areas, Plasmodium vivax has become the predominant parasite. To gain a better understanding of transmission dynamics, knowledge on the changes of P. vivax populations after the scale-up of control interventions will guide more effective targeted control efforts. Methods This study investigated genetic diversity and population structures in 206 P. vivax clinical samples collected at two time points in two international border areas: the China-Myanmar border (CMB) (n = 50 in 2004 and n = 52 in 2016) and Thailand-Myanmar border (TMB) (n = 50 in 2012 and n = 54 in 2015). Parasites were genotyped using 10 microsatellite markers. Results Despite intensified control efforts, genetic diversity remained high (H E = 0.66–0.86) and was not significantly different among the four populations (P > 0.05). Specifically, H E slightly decreased from 0.76 in 2004 to 0.66 in 2016 at the CMB and increased from 0.80 in 2012 to 0.86 in 2015 at the TMB. The proportions of polyclonal infections varied significantly among the four populations (P < 0.05), and showed substantial decreases from 48.0% in 2004 to 23.7 at the CMB and from 40.0% in 2012 to 30.7% in 2015 at the TMB, with corresponding decreases in the multiplicity of infection. Consistent with the continuous decline of malaria incidence in the GMS over time, there were also increases in multilocus linkage disequilibrium, suggesting more fragmented and increasingly inbred parasite populations. There were considerable genetic differentiation and sub-division among the four tested populations. Temporal genetic differentiation was observed at each site (F ST = 0.081 at the CMB and F ST = 0.133 at the TMB). Various degrees of clustering were evident between the older parasite samples collected in 2004 at the CMB and the ... |
format |
Article in Journal/Newspaper |
author |
Yuling Li Yubing Hu Yan Zhao Qinghui Wang Huguette Gaelle Ngassa Mbenda Veerayuth Kittichai Saranath Lawpoolsri Jetsumon Sattabongkot Lynette Menezes Xiaoming Liu Liwang Cui Yaming Cao |
author_facet |
Yuling Li Yubing Hu Yan Zhao Qinghui Wang Huguette Gaelle Ngassa Mbenda Veerayuth Kittichai Saranath Lawpoolsri Jetsumon Sattabongkot Lynette Menezes Xiaoming Liu Liwang Cui Yaming Cao |
author_sort |
Yuling Li |
title |
Dynamics of Plasmodium vivax populations in border areas of the Greater Mekong sub-region during malaria elimination |
title_short |
Dynamics of Plasmodium vivax populations in border areas of the Greater Mekong sub-region during malaria elimination |
title_full |
Dynamics of Plasmodium vivax populations in border areas of the Greater Mekong sub-region during malaria elimination |
title_fullStr |
Dynamics of Plasmodium vivax populations in border areas of the Greater Mekong sub-region during malaria elimination |
title_full_unstemmed |
Dynamics of Plasmodium vivax populations in border areas of the Greater Mekong sub-region during malaria elimination |
title_sort |
dynamics of plasmodium vivax populations in border areas of the greater mekong sub-region during malaria elimination |
publisher |
BMC |
publishDate |
2020 |
url |
https://doi.org/10.1186/s12936-020-03221-9 https://doaj.org/article/8732953d7ea64ad49f6a75c429a673bc |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 19, Iss 1, Pp 1-12 (2020) |
op_relation |
http://link.springer.com/article/10.1186/s12936-020-03221-9 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-03221-9 1475-2875 https://doaj.org/article/8732953d7ea64ad49f6a75c429a673bc |
op_doi |
https://doi.org/10.1186/s12936-020-03221-9 |
container_title |
Malaria Journal |
container_volume |
19 |
container_issue |
1 |
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1766348542486511616 |