Lipase-Catalyzed Kinetic Resolution of Dimethyl and Dibutyl 1-Butyryloxy-1-carboxymethylphosphonates

• Published in: Catalysts
• Main Author: Paulina Majewska
• Format: Article in Journal/Newspaper
• Language: English
• Published: MDPI AG 2021
• Subjects: biocatalysis; hydroxyphosphonates; lipolytic activity; determination of absolute configuration; enantiomers; Chemical technology; TP1-1185; Chemistry; QD1-999; Rugosa; Antarc*; Antarctica
• Online Access: https://doi.org/10.3390/catal11080956; https://doaj.org/article/8720d5598912469a98a31e9d65e47332

The main objective of this study is the enantioselective synthesis of carboxyhydroxyphosphonates by lipase-catalyzed reactions. For this purpose, racemic dimethyl and dibutyl 1-butyryloxy-1-carboxymethylphosphonates were synthesized and hydrolyzed, using a wide spectrum of commercially available lip...