Zoonotic risk factors associated with seroprevalence of Ebola virus GP antibodies in the absence of diagnosed Ebola virus disease in the Democratic Republic of Congo.
Background Ebola virus (EBOV) is a zoonotic filovirus spread through exposure to infected bodily fluids of a human or animal. Though EBOV is capable of causing severe disease, referred to as Ebola Virus Disease (EVD), individuals who have never been diagnosed with confirmed, probable or suspected EV...
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ftdoajarticles:oai:doaj.org/article:871d5746511a4940b0221940a83b5424 2023-05-15T15:12:19+02:00 Zoonotic risk factors associated with seroprevalence of Ebola virus GP antibodies in the absence of diagnosed Ebola virus disease in the Democratic Republic of Congo. Anna Bratcher Nicole A Hoff Reena H Doshi Adva Gadoth Megan Halbrook Patrick Mukadi Kamy Musene Benoit Ilunga-Kebela D'Andre Spencer Matthew S Bramble David McIlwan J Daniel Kelly Daniel Mukadi Placide Mbala Kingebeni Steve Ahuka Emile Okitolonda-Wemakoy Jean-Jacques Muyembe-Tamfum Anne W Rimoin 2021-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009566 https://doaj.org/article/871d5746511a4940b0221940a83b5424 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009566 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009566 https://doaj.org/article/871d5746511a4940b0221940a83b5424 PLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009566 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009566 2022-12-30T22:27:12Z Background Ebola virus (EBOV) is a zoonotic filovirus spread through exposure to infected bodily fluids of a human or animal. Though EBOV is capable of causing severe disease, referred to as Ebola Virus Disease (EVD), individuals who have never been diagnosed with confirmed, probable or suspected EVD can have detectable EBOV antigen-specific antibodies in their blood. This study aims to identify risk factors associated with detectable antibody levels in the absence of an EVD diagnosis. Methodology Data was collected from September 2015 to August 2017 from 1,366 consenting individuals across four study sites in the DRC (Boende, Kabondo-Dianda, Kikwit, and Yambuku). Seroreactivity was determined to EBOV GP IgG using Zaire Ebola Virus Glycoprotein (EBOV GP antigen) ELISA kits (Alpha Diagnostic International, Inc.) in Kinshasa, DRC; any result above 4.7 units/mL was considered seroreactive. Among the respondents, 113 (8.3%) were considered seroreactive. Several zoonotic exposures were associated with EBOV seroreactivity after controlling for age, sex, healthcare worker status, location, and history of contact with an EVD case, namely: ever having contact with bats, ever having contact with rodents, and ever eating non-human primate meat. Contact with monkeys or non-human primates was not associated with seroreactivity. Conclusions This analysis suggests that some zoonotic exposures that have been linked to EVD outbreaks can also be associated with EBOV GP seroreactivity in the absence of diagnosed EVD. Future investigations should seek to clarify the relationships between zoonotic exposures, seroreactivity, asymptomatic infection, and EVD. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 8 e0009566 |
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Directory of Open Access Journals: DOAJ Articles |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Anna Bratcher Nicole A Hoff Reena H Doshi Adva Gadoth Megan Halbrook Patrick Mukadi Kamy Musene Benoit Ilunga-Kebela D'Andre Spencer Matthew S Bramble David McIlwan J Daniel Kelly Daniel Mukadi Placide Mbala Kingebeni Steve Ahuka Emile Okitolonda-Wemakoy Jean-Jacques Muyembe-Tamfum Anne W Rimoin Zoonotic risk factors associated with seroprevalence of Ebola virus GP antibodies in the absence of diagnosed Ebola virus disease in the Democratic Republic of Congo. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Ebola virus (EBOV) is a zoonotic filovirus spread through exposure to infected bodily fluids of a human or animal. Though EBOV is capable of causing severe disease, referred to as Ebola Virus Disease (EVD), individuals who have never been diagnosed with confirmed, probable or suspected EVD can have detectable EBOV antigen-specific antibodies in their blood. This study aims to identify risk factors associated with detectable antibody levels in the absence of an EVD diagnosis. Methodology Data was collected from September 2015 to August 2017 from 1,366 consenting individuals across four study sites in the DRC (Boende, Kabondo-Dianda, Kikwit, and Yambuku). Seroreactivity was determined to EBOV GP IgG using Zaire Ebola Virus Glycoprotein (EBOV GP antigen) ELISA kits (Alpha Diagnostic International, Inc.) in Kinshasa, DRC; any result above 4.7 units/mL was considered seroreactive. Among the respondents, 113 (8.3%) were considered seroreactive. Several zoonotic exposures were associated with EBOV seroreactivity after controlling for age, sex, healthcare worker status, location, and history of contact with an EVD case, namely: ever having contact with bats, ever having contact with rodents, and ever eating non-human primate meat. Contact with monkeys or non-human primates was not associated with seroreactivity. Conclusions This analysis suggests that some zoonotic exposures that have been linked to EVD outbreaks can also be associated with EBOV GP seroreactivity in the absence of diagnosed EVD. Future investigations should seek to clarify the relationships between zoonotic exposures, seroreactivity, asymptomatic infection, and EVD. |
format |
Article in Journal/Newspaper |
author |
Anna Bratcher Nicole A Hoff Reena H Doshi Adva Gadoth Megan Halbrook Patrick Mukadi Kamy Musene Benoit Ilunga-Kebela D'Andre Spencer Matthew S Bramble David McIlwan J Daniel Kelly Daniel Mukadi Placide Mbala Kingebeni Steve Ahuka Emile Okitolonda-Wemakoy Jean-Jacques Muyembe-Tamfum Anne W Rimoin |
author_facet |
Anna Bratcher Nicole A Hoff Reena H Doshi Adva Gadoth Megan Halbrook Patrick Mukadi Kamy Musene Benoit Ilunga-Kebela D'Andre Spencer Matthew S Bramble David McIlwan J Daniel Kelly Daniel Mukadi Placide Mbala Kingebeni Steve Ahuka Emile Okitolonda-Wemakoy Jean-Jacques Muyembe-Tamfum Anne W Rimoin |
author_sort |
Anna Bratcher |
title |
Zoonotic risk factors associated with seroprevalence of Ebola virus GP antibodies in the absence of diagnosed Ebola virus disease in the Democratic Republic of Congo. |
title_short |
Zoonotic risk factors associated with seroprevalence of Ebola virus GP antibodies in the absence of diagnosed Ebola virus disease in the Democratic Republic of Congo. |
title_full |
Zoonotic risk factors associated with seroprevalence of Ebola virus GP antibodies in the absence of diagnosed Ebola virus disease in the Democratic Republic of Congo. |
title_fullStr |
Zoonotic risk factors associated with seroprevalence of Ebola virus GP antibodies in the absence of diagnosed Ebola virus disease in the Democratic Republic of Congo. |
title_full_unstemmed |
Zoonotic risk factors associated with seroprevalence of Ebola virus GP antibodies in the absence of diagnosed Ebola virus disease in the Democratic Republic of Congo. |
title_sort |
zoonotic risk factors associated with seroprevalence of ebola virus gp antibodies in the absence of diagnosed ebola virus disease in the democratic republic of congo. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009566 https://doaj.org/article/871d5746511a4940b0221940a83b5424 |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
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Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009566 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009566 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009566 https://doaj.org/article/871d5746511a4940b0221940a83b5424 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009566 |
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PLOS Neglected Tropical Diseases |
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15 |
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8 |
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e0009566 |
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