Postnatal symptomatic Zika virus infections in children and adolescents: A systematic review.
Background Recent Zika virus (ZIKV) outbreaks in the Pacific and the Americas have highlighted clinically significant congenital neurological abnormalities resulting from ZIKV infection in pregnancy. However, little is known about ZIKV infections in children and adolescents, a group that is potentia...
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ftdoajarticles:oai:doaj.org/article:871cd1353a344608bc235d209437fbe7 2023-05-15T15:15:32+02:00 Postnatal symptomatic Zika virus infections in children and adolescents: A systematic review. Anna Ramond Ludmila Lobkowicz Nuria Sanchez Clemente Aisling Vaughan Marília Dalva Turchi Annelies Wilder-Smith Elizabeth B Brickley 2020-10-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008612 https://doaj.org/article/871cd1353a344608bc235d209437fbe7 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008612 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008612 https://doaj.org/article/871cd1353a344608bc235d209437fbe7 PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008612 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008612 2022-12-31T07:51:21Z Background Recent Zika virus (ZIKV) outbreaks in the Pacific and the Americas have highlighted clinically significant congenital neurological abnormalities resulting from ZIKV infection in pregnancy. However, little is known about ZIKV infections in children and adolescents, a group that is potentially vulnerable to ZIKV neurovirulence. Methods We conducted a systematic review on the clinical presentation and complications of children and adolescents aged 0 to 18 years with a robust diagnosis of ZIKV infection. We searched PubMed, Web of Science, LILACs, and EMBASE until 13 February 2020 and screened reference lists of eligible articles. We assessed the studies' risk of bias using pre-specified criteria. Findings Our review collated the evidence from 2543 pediatric ZIKV cases representing 17 countries and territories, identified in 1 cohort study, 9 case series and 22 case reports. The most commonly observed signs and symptoms of ZIKV infection in children and adolescents were mild and included fever, rash, conjunctivitis and arthralgia. The frequency of neurological complications was reported only in the largest case series (identified in 1.0% of cases) and in an additional 14 children identified from hospital-based surveillance studies and case reports. ZIKV-related mortality was primarily accompanied by co-morbidity and was reported in one case series (<0.5% of cases) and three case reports. One death was attributed to complications of Guillain-Barré Syndrome secondary to ZIKV infection. Conclusions and relevance Based on the current evidence, the clinical presentation of ZIKV infection in children and adolescents appears to be primarily mild and similar to the presentation in adults, with rare instances of severe complications and/or mortality. However, reliable estimation of the risks of ZIKV complications in these age groups is limited by the scarcity and quality of published data. Additional prospective studies are needed to improve understanding of the relative frequency of the signs, symptoms, and ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Barré ENVELOPE(-68.550,-68.550,-67.500,-67.500) Pacific PLOS Neglected Tropical Diseases 14 10 e0008612 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Anna Ramond Ludmila Lobkowicz Nuria Sanchez Clemente Aisling Vaughan Marília Dalva Turchi Annelies Wilder-Smith Elizabeth B Brickley Postnatal symptomatic Zika virus infections in children and adolescents: A systematic review. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Recent Zika virus (ZIKV) outbreaks in the Pacific and the Americas have highlighted clinically significant congenital neurological abnormalities resulting from ZIKV infection in pregnancy. However, little is known about ZIKV infections in children and adolescents, a group that is potentially vulnerable to ZIKV neurovirulence. Methods We conducted a systematic review on the clinical presentation and complications of children and adolescents aged 0 to 18 years with a robust diagnosis of ZIKV infection. We searched PubMed, Web of Science, LILACs, and EMBASE until 13 February 2020 and screened reference lists of eligible articles. We assessed the studies' risk of bias using pre-specified criteria. Findings Our review collated the evidence from 2543 pediatric ZIKV cases representing 17 countries and territories, identified in 1 cohort study, 9 case series and 22 case reports. The most commonly observed signs and symptoms of ZIKV infection in children and adolescents were mild and included fever, rash, conjunctivitis and arthralgia. The frequency of neurological complications was reported only in the largest case series (identified in 1.0% of cases) and in an additional 14 children identified from hospital-based surveillance studies and case reports. ZIKV-related mortality was primarily accompanied by co-morbidity and was reported in one case series (<0.5% of cases) and three case reports. One death was attributed to complications of Guillain-Barré Syndrome secondary to ZIKV infection. Conclusions and relevance Based on the current evidence, the clinical presentation of ZIKV infection in children and adolescents appears to be primarily mild and similar to the presentation in adults, with rare instances of severe complications and/or mortality. However, reliable estimation of the risks of ZIKV complications in these age groups is limited by the scarcity and quality of published data. Additional prospective studies are needed to improve understanding of the relative frequency of the signs, symptoms, and ... |
format |
Article in Journal/Newspaper |
author |
Anna Ramond Ludmila Lobkowicz Nuria Sanchez Clemente Aisling Vaughan Marília Dalva Turchi Annelies Wilder-Smith Elizabeth B Brickley |
author_facet |
Anna Ramond Ludmila Lobkowicz Nuria Sanchez Clemente Aisling Vaughan Marília Dalva Turchi Annelies Wilder-Smith Elizabeth B Brickley |
author_sort |
Anna Ramond |
title |
Postnatal symptomatic Zika virus infections in children and adolescents: A systematic review. |
title_short |
Postnatal symptomatic Zika virus infections in children and adolescents: A systematic review. |
title_full |
Postnatal symptomatic Zika virus infections in children and adolescents: A systematic review. |
title_fullStr |
Postnatal symptomatic Zika virus infections in children and adolescents: A systematic review. |
title_full_unstemmed |
Postnatal symptomatic Zika virus infections in children and adolescents: A systematic review. |
title_sort |
postnatal symptomatic zika virus infections in children and adolescents: a systematic review. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008612 https://doaj.org/article/871cd1353a344608bc235d209437fbe7 |
long_lat |
ENVELOPE(-68.550,-68.550,-67.500,-67.500) |
geographic |
Arctic Barré Pacific |
geographic_facet |
Arctic Barré Pacific |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008612 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008612 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008612 https://doaj.org/article/871cd1353a344608bc235d209437fbe7 |
op_doi |
https://doi.org/10.1371/journal.pntd.0008612 |
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PLOS Neglected Tropical Diseases |
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14 |
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10 |
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e0008612 |
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