microRNA profiles and functions in mosquitoes.
Mosquitoes are incriminated as vectors for many crippling diseases, including malaria, West Nile fever, Dengue fever, and other neglected tropical diseases (NTDs). microRNAs (miRNAs) can interact with multiple target genes to elicit biological functions in the mosquitoes. However, characterization a...
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ftdoajarticles:oai:doaj.org/article:8704c2dbe01a469d818de92d50af90aa 2023-05-15T15:05:06+02:00 microRNA profiles and functions in mosquitoes. Xinyu Feng Shuisen Zhou Jingwen Wang Wei Hu 2018-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006463 https://doaj.org/article/8704c2dbe01a469d818de92d50af90aa EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5951587?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006463 https://doaj.org/article/8704c2dbe01a469d818de92d50af90aa PLoS Neglected Tropical Diseases, Vol 12, Iss 5, p e0006463 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006463 2022-12-30T23:08:40Z Mosquitoes are incriminated as vectors for many crippling diseases, including malaria, West Nile fever, Dengue fever, and other neglected tropical diseases (NTDs). microRNAs (miRNAs) can interact with multiple target genes to elicit biological functions in the mosquitoes. However, characterization and function of individual miRNAs and their potential targets have not been fully determined to date. We conducted a systematic review of published literature following PRISMA guidelines. We summarize the information about miRNAs in mosquitoes to better understand their metabolism, development, and responses to microorganisms. Depending on the study, we found that miRNAs were dysregulated in a species-, sex-, stage-, and tissue/organ-specific manner. Aberrant miRNA expressions were observed in development, metabolism, host-pathogen interactions, and insecticide resistance. Of note, many miRNAs were down-regulated upon pathogen infection. The experimental studies have expanded the identification of miRNA target from the 3' untranslated regions (UTRs) of mRNAs of mosquitoes to the 5' UTRs of mRNAs of the virus. In addition, we discuss current trends in mosquito miRNA research and offer suggestions for future studies. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Prisma ENVELOPE(-58.767,-58.767,-69.200,-69.200) PLOS Neglected Tropical Diseases 12 5 e0006463 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Xinyu Feng Shuisen Zhou Jingwen Wang Wei Hu microRNA profiles and functions in mosquitoes. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Mosquitoes are incriminated as vectors for many crippling diseases, including malaria, West Nile fever, Dengue fever, and other neglected tropical diseases (NTDs). microRNAs (miRNAs) can interact with multiple target genes to elicit biological functions in the mosquitoes. However, characterization and function of individual miRNAs and their potential targets have not been fully determined to date. We conducted a systematic review of published literature following PRISMA guidelines. We summarize the information about miRNAs in mosquitoes to better understand their metabolism, development, and responses to microorganisms. Depending on the study, we found that miRNAs were dysregulated in a species-, sex-, stage-, and tissue/organ-specific manner. Aberrant miRNA expressions were observed in development, metabolism, host-pathogen interactions, and insecticide resistance. Of note, many miRNAs were down-regulated upon pathogen infection. The experimental studies have expanded the identification of miRNA target from the 3' untranslated regions (UTRs) of mRNAs of mosquitoes to the 5' UTRs of mRNAs of the virus. In addition, we discuss current trends in mosquito miRNA research and offer suggestions for future studies. |
format |
Article in Journal/Newspaper |
author |
Xinyu Feng Shuisen Zhou Jingwen Wang Wei Hu |
author_facet |
Xinyu Feng Shuisen Zhou Jingwen Wang Wei Hu |
author_sort |
Xinyu Feng |
title |
microRNA profiles and functions in mosquitoes. |
title_short |
microRNA profiles and functions in mosquitoes. |
title_full |
microRNA profiles and functions in mosquitoes. |
title_fullStr |
microRNA profiles and functions in mosquitoes. |
title_full_unstemmed |
microRNA profiles and functions in mosquitoes. |
title_sort |
microrna profiles and functions in mosquitoes. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006463 https://doaj.org/article/8704c2dbe01a469d818de92d50af90aa |
long_lat |
ENVELOPE(-58.767,-58.767,-69.200,-69.200) |
geographic |
Arctic Prisma |
geographic_facet |
Arctic Prisma |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 5, p e0006463 (2018) |
op_relation |
http://europepmc.org/articles/PMC5951587?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006463 https://doaj.org/article/8704c2dbe01a469d818de92d50af90aa |
op_doi |
https://doi.org/10.1371/journal.pntd.0006463 |
container_title |
PLOS Neglected Tropical Diseases |
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12 |
container_issue |
5 |
container_start_page |
e0006463 |
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1766336851564560384 |