Characterization of the β-tubulin gene family in Ascaris lumbricoides and Ascaris suum and its implication for the molecular detection of benzimidazole resistance.

• Published in: PLOS Neglected Tropical Diseases
• Main Authors: Sara Roose, Russell W Avramenko, Stephen M J Pollo, James D Wasmuth, Shaali Ame, Mio Ayana, Martha Betson, Piet Cools, Daniel Dana, Ben P Jones, Zeleke Mekonnen, Arianna Morosetti, Abhinaya Venkatesan, Johnny Vlaminck, Matthew L Workentine, Bruno Levecke, John S Gilleard, Peter Geldhof
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2021
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Tac
• Online Access: https://doi.org/10.1371/journal.pntd.0009777; https://doaj.org/article/86f669650eef4fdf80d0e28f19248226

Background The treatment coverage of control programs providing benzimidazole (BZ) drugs to eliminate the morbidity caused by soil-transmitted helminths (STHs) is unprecedently high. This high drug pressure may result in the development of BZ resistance in STHs and so there is an urgent need for sur...