Anti-malarial effect of gum arabic
Abstract Background Gum Arabic (GA), a nonabsorbable nutrient from the exudate of Acacia senegal , exerts a powerful immunomodulatory effect on dendritic cells, antigen-presenting cells involved in the initiation of both innate and adaptive immunity. On the other hand GA degradation delivers short c...
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ftdoajarticles:oai:doaj.org/article:86e0bc938f3d443e8b9c35746f50d56f 2023-05-15T15:10:14+02:00 Anti-malarial effect of gum arabic Nasir Omaima Kempe Daniela Föller Michael Qadri Syed M Bobbala Diwakar Ballal Adil Saeed Amal Lang Florian 2011-05-01T00:00:00Z https://doi.org/10.1186/1475-2875-10-139 https://doaj.org/article/86e0bc938f3d443e8b9c35746f50d56f EN eng BMC http://www.malariajournal.com/content/10/1/139 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-139 1475-2875 https://doaj.org/article/86e0bc938f3d443e8b9c35746f50d56f Malaria Journal, Vol 10, Iss 1, p 139 (2011) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2011 ftdoajarticles https://doi.org/10.1186/1475-2875-10-139 2022-12-31T01:20:50Z Abstract Background Gum Arabic (GA), a nonabsorbable nutrient from the exudate of Acacia senegal , exerts a powerful immunomodulatory effect on dendritic cells, antigen-presenting cells involved in the initiation of both innate and adaptive immunity. On the other hand GA degradation delivers short chain fatty acids, which in turn have been shown to foster the expression of foetal haemoglobin in erythrocytes. Increased levels of erythrocyte foetal haemoglobin are known to impede the intraerythrocytic growth of Plasmodium and thus confer some protection against malaria. The present study tested whether gum arabic may influence the clinical course of malaria. Methods Human erythrocytes were in vitro infected with Plasmodium falciparum in the absence and presence of butyrate and mice were in vivo infected with Plasmodium berghei ANKA by injecting parasitized murine erythrocytes (1 × 10 6 ) intraperitoneally. Half of the mice received gum arabic (10% in drinking water starting 10 days before the day of infection). Results According to the in vitro experiments butyrate significantly blunted parasitaemia only at concentrations much higher (3 mM) than those encountered in vivo following GA ingestion (<1 μM). According to the in vivo experiments the administration of gum arabic slightly but significantly decreased the parasitaemia and significantly extended the life span of infected mice. Discussion GA moderately influences the parasitaemia and survival of Plasmodium- infected mice. The underlying mechanism remained, however, elusive. Conclusions Gum arabic favourably influences the course of murine malaria. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 10 1 139 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Nasir Omaima Kempe Daniela Föller Michael Qadri Syed M Bobbala Diwakar Ballal Adil Saeed Amal Lang Florian Anti-malarial effect of gum arabic |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Gum Arabic (GA), a nonabsorbable nutrient from the exudate of Acacia senegal , exerts a powerful immunomodulatory effect on dendritic cells, antigen-presenting cells involved in the initiation of both innate and adaptive immunity. On the other hand GA degradation delivers short chain fatty acids, which in turn have been shown to foster the expression of foetal haemoglobin in erythrocytes. Increased levels of erythrocyte foetal haemoglobin are known to impede the intraerythrocytic growth of Plasmodium and thus confer some protection against malaria. The present study tested whether gum arabic may influence the clinical course of malaria. Methods Human erythrocytes were in vitro infected with Plasmodium falciparum in the absence and presence of butyrate and mice were in vivo infected with Plasmodium berghei ANKA by injecting parasitized murine erythrocytes (1 × 10 6 ) intraperitoneally. Half of the mice received gum arabic (10% in drinking water starting 10 days before the day of infection). Results According to the in vitro experiments butyrate significantly blunted parasitaemia only at concentrations much higher (3 mM) than those encountered in vivo following GA ingestion (<1 μM). According to the in vivo experiments the administration of gum arabic slightly but significantly decreased the parasitaemia and significantly extended the life span of infected mice. Discussion GA moderately influences the parasitaemia and survival of Plasmodium- infected mice. The underlying mechanism remained, however, elusive. Conclusions Gum arabic favourably influences the course of murine malaria. |
format |
Article in Journal/Newspaper |
author |
Nasir Omaima Kempe Daniela Föller Michael Qadri Syed M Bobbala Diwakar Ballal Adil Saeed Amal Lang Florian |
author_facet |
Nasir Omaima Kempe Daniela Föller Michael Qadri Syed M Bobbala Diwakar Ballal Adil Saeed Amal Lang Florian |
author_sort |
Nasir Omaima |
title |
Anti-malarial effect of gum arabic |
title_short |
Anti-malarial effect of gum arabic |
title_full |
Anti-malarial effect of gum arabic |
title_fullStr |
Anti-malarial effect of gum arabic |
title_full_unstemmed |
Anti-malarial effect of gum arabic |
title_sort |
anti-malarial effect of gum arabic |
publisher |
BMC |
publishDate |
2011 |
url |
https://doi.org/10.1186/1475-2875-10-139 https://doaj.org/article/86e0bc938f3d443e8b9c35746f50d56f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 10, Iss 1, p 139 (2011) |
op_relation |
http://www.malariajournal.com/content/10/1/139 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-139 1475-2875 https://doaj.org/article/86e0bc938f3d443e8b9c35746f50d56f |
op_doi |
https://doi.org/10.1186/1475-2875-10-139 |
container_title |
Malaria Journal |
container_volume |
10 |
container_issue |
1 |
container_start_page |
139 |
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1766341278222516224 |