Normative Values of Retinal Oxygen Saturation in Rhesus Monkeys: The Beijing Intracranial and Intraocular Pressure (iCOP) Study.
To study the normal values of the retinal oxygen saturation in Rhesus monkeys and to evaluated repeatability and reproducibility of retinal oxygen saturation measurements.Eighteen adult Rhesus macaque monkeys were included in this experimental study. An Oxymap T1 retinal oximeter (Oxymap, Reykjavik,...
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ftdoajarticles:oai:doaj.org/article:86c79e516d0e4c309a3a2ece3d05f159 2023-05-15T16:51:36+02:00 Normative Values of Retinal Oxygen Saturation in Rhesus Monkeys: The Beijing Intracranial and Intraocular Pressure (iCOP) Study. Jing Li Yiquan Yang Diya Yang Xiangxiang Liu Yunxiao Sun Shifei Wei Ningli Wang 2016-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0150072 https://doaj.org/article/86c79e516d0e4c309a3a2ece3d05f159 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4773038?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0150072 https://doaj.org/article/86c79e516d0e4c309a3a2ece3d05f159 PLoS ONE, Vol 11, Iss 3, p e0150072 (2016) Medicine R Science Q article 2016 ftdoajarticles https://doi.org/10.1371/journal.pone.0150072 2022-12-31T15:51:56Z To study the normal values of the retinal oxygen saturation in Rhesus monkeys and to evaluated repeatability and reproducibility of retinal oxygen saturation measurements.Eighteen adult Rhesus macaque monkeys were included in this experimental study. An Oxymap T1 retinal oximeter (Oxymap, Reykjavik, Iceland) was used to perform oximetry on all subjects. Global arterial (SaO2) and venous oxygen saturation (SvO2), arteriovenous difference in SO2 were measured. In the first examination, each eye was imaged three times. At the following two examinations, each eye was imaged once. All examinations were finished in one month. P values were calculated to evaluate the difference between the measurements during three visits by performing an ANOVA. Intra-visit and inter-visit intraclass correlation coefficient (ICC) was determined.At baseline, the average SaO2 and SvO2 were 89.48 ± 2.64% and 54.85 ± 2.18%, respectively. The global A-V difference was 34.63 ± 1.91%. The difference between the three visits was not significant (p>0.05). The highest A-V difference in SO2 and lowest saturations were found in the inferotemporal quadrant. Intra-session and inter-visit repeatability were both high. For all oxygen saturation parameters, the ICC values of the intra-session repeatability ranged between 0.92 and 0.96. As found previously, a relatively high ICC value for inter-visit repeatability also was found for all oxygen saturation measurements, ranging between 0.86 and 0.94, with the lowest values in the infero-nasal quadrant.Our study is the first to describe retinal SO2 in healthy Rhesus monkeys. In normal monkey eyes, the reproducibility and repeatability of retinal oximetry oxygen saturation measurements were high in the retinal arterioles and venules. Our results support that Oxymap T1 retinal oximetry is a suitable and reliable technique in monkey studies. Article in Journal/Newspaper Iceland Directory of Open Access Journals: DOAJ Articles PLOS ONE 11 3 e0150072 |
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Medicine R Science Q Jing Li Yiquan Yang Diya Yang Xiangxiang Liu Yunxiao Sun Shifei Wei Ningli Wang Normative Values of Retinal Oxygen Saturation in Rhesus Monkeys: The Beijing Intracranial and Intraocular Pressure (iCOP) Study. |
topic_facet |
Medicine R Science Q |
description |
To study the normal values of the retinal oxygen saturation in Rhesus monkeys and to evaluated repeatability and reproducibility of retinal oxygen saturation measurements.Eighteen adult Rhesus macaque monkeys were included in this experimental study. An Oxymap T1 retinal oximeter (Oxymap, Reykjavik, Iceland) was used to perform oximetry on all subjects. Global arterial (SaO2) and venous oxygen saturation (SvO2), arteriovenous difference in SO2 were measured. In the first examination, each eye was imaged three times. At the following two examinations, each eye was imaged once. All examinations were finished in one month. P values were calculated to evaluate the difference between the measurements during three visits by performing an ANOVA. Intra-visit and inter-visit intraclass correlation coefficient (ICC) was determined.At baseline, the average SaO2 and SvO2 were 89.48 ± 2.64% and 54.85 ± 2.18%, respectively. The global A-V difference was 34.63 ± 1.91%. The difference between the three visits was not significant (p>0.05). The highest A-V difference in SO2 and lowest saturations were found in the inferotemporal quadrant. Intra-session and inter-visit repeatability were both high. For all oxygen saturation parameters, the ICC values of the intra-session repeatability ranged between 0.92 and 0.96. As found previously, a relatively high ICC value for inter-visit repeatability also was found for all oxygen saturation measurements, ranging between 0.86 and 0.94, with the lowest values in the infero-nasal quadrant.Our study is the first to describe retinal SO2 in healthy Rhesus monkeys. In normal monkey eyes, the reproducibility and repeatability of retinal oximetry oxygen saturation measurements were high in the retinal arterioles and venules. Our results support that Oxymap T1 retinal oximetry is a suitable and reliable technique in monkey studies. |
format |
Article in Journal/Newspaper |
author |
Jing Li Yiquan Yang Diya Yang Xiangxiang Liu Yunxiao Sun Shifei Wei Ningli Wang |
author_facet |
Jing Li Yiquan Yang Diya Yang Xiangxiang Liu Yunxiao Sun Shifei Wei Ningli Wang |
author_sort |
Jing Li |
title |
Normative Values of Retinal Oxygen Saturation in Rhesus Monkeys: The Beijing Intracranial and Intraocular Pressure (iCOP) Study. |
title_short |
Normative Values of Retinal Oxygen Saturation in Rhesus Monkeys: The Beijing Intracranial and Intraocular Pressure (iCOP) Study. |
title_full |
Normative Values of Retinal Oxygen Saturation in Rhesus Monkeys: The Beijing Intracranial and Intraocular Pressure (iCOP) Study. |
title_fullStr |
Normative Values of Retinal Oxygen Saturation in Rhesus Monkeys: The Beijing Intracranial and Intraocular Pressure (iCOP) Study. |
title_full_unstemmed |
Normative Values of Retinal Oxygen Saturation in Rhesus Monkeys: The Beijing Intracranial and Intraocular Pressure (iCOP) Study. |
title_sort |
normative values of retinal oxygen saturation in rhesus monkeys: the beijing intracranial and intraocular pressure (icop) study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pone.0150072 https://doaj.org/article/86c79e516d0e4c309a3a2ece3d05f159 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
PLoS ONE, Vol 11, Iss 3, p e0150072 (2016) |
op_relation |
http://europepmc.org/articles/PMC4773038?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0150072 https://doaj.org/article/86c79e516d0e4c309a3a2ece3d05f159 |
op_doi |
https://doi.org/10.1371/journal.pone.0150072 |
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PLOS ONE |
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11 |
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3 |
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e0150072 |
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