Quality Assessment of Some Essential Children’s Medicines Sold in Licensed Outlets in Ashanti Region, Ghana
The quality of 68 samples of 15 different essential children’s medicines sold in licensed medicine outlets in the Ashanti Region, Ghana, was evaluated. Thirty-two (47.1%) of the medicines were imported, mainly from India (65.6%) and the United Kingdom (28.1%), while 36 (52.9%) were locally manufactu...
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ftdoajarticles:oai:doaj.org/article:86c389a59b1f48ab9a48bcb1f9742b2a 2024-09-09T19:26:21+00:00 Quality Assessment of Some Essential Children’s Medicines Sold in Licensed Outlets in Ashanti Region, Ghana Grace Frimpong Kwabena Ofori-Kwakye Noble Kuntworbe Kwame Ohene Buabeng Yaa Asantewaa Osei Mariam El Boakye-Gyasi Ofosua Adi-Dako 2018-01-01T00:00:00Z https://doi.org/10.1155/2018/1494957 https://doaj.org/article/86c389a59b1f48ab9a48bcb1f9742b2a EN eng Wiley http://dx.doi.org/10.1155/2018/1494957 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2018/1494957 https://doaj.org/article/86c389a59b1f48ab9a48bcb1f9742b2a Journal of Tropical Medicine, Vol 2018 (2018) Arctic medicine. Tropical medicine RC955-962 article 2018 ftdoajarticles https://doi.org/10.1155/2018/1494957 2024-08-05T17:48:45Z The quality of 68 samples of 15 different essential children’s medicines sold in licensed medicine outlets in the Ashanti Region, Ghana, was evaluated. Thirty-two (47.1%) of the medicines were imported, mainly from India (65.6%) and the United Kingdom (28.1%), while 36 (52.9%) were locally manufactured. The quality of the medicines was assessed using content of active pharmaceutical ingredient (API), pH, and microbial limit tests, and the results were compared with pharmacopoeial standards. Twenty-six (38.2%) of the samples studied passed the official content of API test while 42 (61.8%) failed. Forty-nine (72.1%) of the samples were compliant with official specifications for pH while 19 (27.9%) were noncompliant. Sixty-six (97.1%) samples passed the microbial load and content test while 2 (2.9%) failed. Eighteen (26.5%) samples passed all the three quality evaluation tests, while one (1.5%) sample (CFX1) failed all the tests. All the amoxicillin suspensions tested passed the three evaluation tests. All the ciprofloxacin, cotrimoxazole, flucloxacillin, artemether-lumefantrine, multivitamin, and folic acid samples failed the content of API test and are substandard. The overall API failure rate for imported products (59.4%) was comparable to locally manufactured (63.9%) samples. The results highlight the poor quality of the children’s medicines studied and underscore the need for regular pharmacovigilance and surveillance systems to fight this menace. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2018 1 14 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Grace Frimpong Kwabena Ofori-Kwakye Noble Kuntworbe Kwame Ohene Buabeng Yaa Asantewaa Osei Mariam El Boakye-Gyasi Ofosua Adi-Dako Quality Assessment of Some Essential Children’s Medicines Sold in Licensed Outlets in Ashanti Region, Ghana |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
The quality of 68 samples of 15 different essential children’s medicines sold in licensed medicine outlets in the Ashanti Region, Ghana, was evaluated. Thirty-two (47.1%) of the medicines were imported, mainly from India (65.6%) and the United Kingdom (28.1%), while 36 (52.9%) were locally manufactured. The quality of the medicines was assessed using content of active pharmaceutical ingredient (API), pH, and microbial limit tests, and the results were compared with pharmacopoeial standards. Twenty-six (38.2%) of the samples studied passed the official content of API test while 42 (61.8%) failed. Forty-nine (72.1%) of the samples were compliant with official specifications for pH while 19 (27.9%) were noncompliant. Sixty-six (97.1%) samples passed the microbial load and content test while 2 (2.9%) failed. Eighteen (26.5%) samples passed all the three quality evaluation tests, while one (1.5%) sample (CFX1) failed all the tests. All the amoxicillin suspensions tested passed the three evaluation tests. All the ciprofloxacin, cotrimoxazole, flucloxacillin, artemether-lumefantrine, multivitamin, and folic acid samples failed the content of API test and are substandard. The overall API failure rate for imported products (59.4%) was comparable to locally manufactured (63.9%) samples. The results highlight the poor quality of the children’s medicines studied and underscore the need for regular pharmacovigilance and surveillance systems to fight this menace. |
format |
Article in Journal/Newspaper |
author |
Grace Frimpong Kwabena Ofori-Kwakye Noble Kuntworbe Kwame Ohene Buabeng Yaa Asantewaa Osei Mariam El Boakye-Gyasi Ofosua Adi-Dako |
author_facet |
Grace Frimpong Kwabena Ofori-Kwakye Noble Kuntworbe Kwame Ohene Buabeng Yaa Asantewaa Osei Mariam El Boakye-Gyasi Ofosua Adi-Dako |
author_sort |
Grace Frimpong |
title |
Quality Assessment of Some Essential Children’s Medicines Sold in Licensed Outlets in Ashanti Region, Ghana |
title_short |
Quality Assessment of Some Essential Children’s Medicines Sold in Licensed Outlets in Ashanti Region, Ghana |
title_full |
Quality Assessment of Some Essential Children’s Medicines Sold in Licensed Outlets in Ashanti Region, Ghana |
title_fullStr |
Quality Assessment of Some Essential Children’s Medicines Sold in Licensed Outlets in Ashanti Region, Ghana |
title_full_unstemmed |
Quality Assessment of Some Essential Children’s Medicines Sold in Licensed Outlets in Ashanti Region, Ghana |
title_sort |
quality assessment of some essential children’s medicines sold in licensed outlets in ashanti region, ghana |
publisher |
Wiley |
publishDate |
2018 |
url |
https://doi.org/10.1155/2018/1494957 https://doaj.org/article/86c389a59b1f48ab9a48bcb1f9742b2a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2018 (2018) |
op_relation |
http://dx.doi.org/10.1155/2018/1494957 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2018/1494957 https://doaj.org/article/86c389a59b1f48ab9a48bcb1f9742b2a |
op_doi |
https://doi.org/10.1155/2018/1494957 |
container_title |
Journal of Tropical Medicine |
container_volume |
2018 |
container_start_page |
1 |
op_container_end_page |
14 |
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1809895992447729664 |