IRES-Containing VEEV Vaccine Protects Cynomolgus Macaques from IE Venezuelan Equine Encephalitis Virus Aerosol Challenge.
Venezuelan equine encephalitis virus (VEEV) is an arbovirus endemic to the Americas that is responsible for severe, sometimes fatal, disease in humans and horses. We previously described an IRES-based VEE vaccine candidate based up the IE serotype that offers complete protection against a lethal sub...
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ftdoajarticles:oai:doaj.org/article:86bf66e5246e4f38be60df686be47c59 2023-05-15T15:03:19+02:00 IRES-Containing VEEV Vaccine Protects Cynomolgus Macaques from IE Venezuelan Equine Encephalitis Virus Aerosol Challenge. Shannan L Rossi Kasi E Russell-Lodrigue Stephanie Z Killeen Eryu Wang Grace Leal Nicholas A Bergren Heather Vinet-Oliphant Scott C Weaver Chad J Roy 2015-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003797 https://doaj.org/article/86bf66e5246e4f38be60df686be47c59 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4447396?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003797 https://doaj.org/article/86bf66e5246e4f38be60df686be47c59 PLoS Neglected Tropical Diseases, Vol 9, Iss 5, p e0003797 (2015) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2015 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003797 2022-12-31T13:35:31Z Venezuelan equine encephalitis virus (VEEV) is an arbovirus endemic to the Americas that is responsible for severe, sometimes fatal, disease in humans and horses. We previously described an IRES-based VEE vaccine candidate based up the IE serotype that offers complete protection against a lethal subtype IE VEEV challenge in mice. Here we demonstrate the IRES-based vaccine's ability to protect against febrile disease in cynomolgus macaques. Vaccination was well tolerated and elicited robust neutralizing antibody titers noticed as early as day 14. Moreover, complete protection from disease characterized by absence of viremia and characteristic fever following aerosolized IE VEEV challenge was observed in all vaccinees compared to control animals, which developed clinical disease. Together, these results highlight the safety and efficacy of IRES-based VEEV vaccine to protect against an endemic, pathogenic VEEV IE serotype. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 9 5 e0003797 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Shannan L Rossi Kasi E Russell-Lodrigue Stephanie Z Killeen Eryu Wang Grace Leal Nicholas A Bergren Heather Vinet-Oliphant Scott C Weaver Chad J Roy IRES-Containing VEEV Vaccine Protects Cynomolgus Macaques from IE Venezuelan Equine Encephalitis Virus Aerosol Challenge. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Venezuelan equine encephalitis virus (VEEV) is an arbovirus endemic to the Americas that is responsible for severe, sometimes fatal, disease in humans and horses. We previously described an IRES-based VEE vaccine candidate based up the IE serotype that offers complete protection against a lethal subtype IE VEEV challenge in mice. Here we demonstrate the IRES-based vaccine's ability to protect against febrile disease in cynomolgus macaques. Vaccination was well tolerated and elicited robust neutralizing antibody titers noticed as early as day 14. Moreover, complete protection from disease characterized by absence of viremia and characteristic fever following aerosolized IE VEEV challenge was observed in all vaccinees compared to control animals, which developed clinical disease. Together, these results highlight the safety and efficacy of IRES-based VEEV vaccine to protect against an endemic, pathogenic VEEV IE serotype. |
format |
Article in Journal/Newspaper |
author |
Shannan L Rossi Kasi E Russell-Lodrigue Stephanie Z Killeen Eryu Wang Grace Leal Nicholas A Bergren Heather Vinet-Oliphant Scott C Weaver Chad J Roy |
author_facet |
Shannan L Rossi Kasi E Russell-Lodrigue Stephanie Z Killeen Eryu Wang Grace Leal Nicholas A Bergren Heather Vinet-Oliphant Scott C Weaver Chad J Roy |
author_sort |
Shannan L Rossi |
title |
IRES-Containing VEEV Vaccine Protects Cynomolgus Macaques from IE Venezuelan Equine Encephalitis Virus Aerosol Challenge. |
title_short |
IRES-Containing VEEV Vaccine Protects Cynomolgus Macaques from IE Venezuelan Equine Encephalitis Virus Aerosol Challenge. |
title_full |
IRES-Containing VEEV Vaccine Protects Cynomolgus Macaques from IE Venezuelan Equine Encephalitis Virus Aerosol Challenge. |
title_fullStr |
IRES-Containing VEEV Vaccine Protects Cynomolgus Macaques from IE Venezuelan Equine Encephalitis Virus Aerosol Challenge. |
title_full_unstemmed |
IRES-Containing VEEV Vaccine Protects Cynomolgus Macaques from IE Venezuelan Equine Encephalitis Virus Aerosol Challenge. |
title_sort |
ires-containing veev vaccine protects cynomolgus macaques from ie venezuelan equine encephalitis virus aerosol challenge. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pntd.0003797 https://doaj.org/article/86bf66e5246e4f38be60df686be47c59 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 9, Iss 5, p e0003797 (2015) |
op_relation |
http://europepmc.org/articles/PMC4447396?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003797 https://doaj.org/article/86bf66e5246e4f38be60df686be47c59 |
op_doi |
https://doi.org/10.1371/journal.pntd.0003797 |
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PLOS Neglected Tropical Diseases |
container_volume |
9 |
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5 |
container_start_page |
e0003797 |
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