Measuring endemicity and burden of leprosy across countries and regions: A systematic review and Delphi survey.
Background Leprosy is a chronic infectious disease caused by Mycobacterium leprae, the annual new case detection in 2019 was 202,189 globally. Measuring endemicity levels and burden in leprosy lacks a uniform approach. As a result, the assessment of leprosy endemicity or burden are not comparable ov...
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ftdoajarticles:oai:doaj.org/article:86b778bcff58484a8dc39b513a3f11fb 2023-05-15T15:15:44+02:00 Measuring endemicity and burden of leprosy across countries and regions: A systematic review and Delphi survey. Dorcas O Ogunsumi Vivek Lal Karl Philipp Puchner Wim van Brakel Eva-Maria Schwienhorst-Stich Christa Kasang Joseph Chukwu Saskia Kreibich Sandra Parisi Jan Hendrik Richardus David J Blok 2021-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009769 https://doaj.org/article/86b778bcff58484a8dc39b513a3f11fb EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009769 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009769 https://doaj.org/article/86b778bcff58484a8dc39b513a3f11fb PLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009769 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009769 2022-12-31T15:16:59Z Background Leprosy is a chronic infectious disease caused by Mycobacterium leprae, the annual new case detection in 2019 was 202,189 globally. Measuring endemicity levels and burden in leprosy lacks a uniform approach. As a result, the assessment of leprosy endemicity or burden are not comparable over time and across countries and regions. This can make program planning and evaluation difficult. This study aims to identify relevant metrics and methods for measuring and classifying leprosy endemicity and burden at (sub)national level. Methods We used a mixed-method approach combining findings from a systematic literature review and a Delphi survey. The literature search was conducted in seven databases, searching for endemicity, burden and leprosy. We reviewed the available evidence on the usage of indicators, classification levels, and scoring methods to measure and classify endemicity and burden. A two round Delphi survey was conducted to ask experts to rank and weigh indicators, classification levels, and scoring methods. Results The literature review showed variation of indicators, levels, and cut-off values to measure leprosy endemicity and/or burden. The most used indicators for endemicity include new case detection rate (NCDR), new cases among children and new cases with grade 2 disability. For burden these include NCDR, MB cases, and prevalence. The classification levels 'high' and 'low' were most important. It was considered most relevant to use separate scoring methods for endemicity and burden. The scores would be derived by use of multiple indicators. Conclusion There is great variation in the existing method for measuring endemicity and burden across countries and regions. Our findings contribute to establishing a standardized uniform approach to measure and classify leprosy endemicity and burden at (sub)national level, which would allow effective communication and planning of intervention strategies. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 9 e0009769 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Dorcas O Ogunsumi Vivek Lal Karl Philipp Puchner Wim van Brakel Eva-Maria Schwienhorst-Stich Christa Kasang Joseph Chukwu Saskia Kreibich Sandra Parisi Jan Hendrik Richardus David J Blok Measuring endemicity and burden of leprosy across countries and regions: A systematic review and Delphi survey. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Leprosy is a chronic infectious disease caused by Mycobacterium leprae, the annual new case detection in 2019 was 202,189 globally. Measuring endemicity levels and burden in leprosy lacks a uniform approach. As a result, the assessment of leprosy endemicity or burden are not comparable over time and across countries and regions. This can make program planning and evaluation difficult. This study aims to identify relevant metrics and methods for measuring and classifying leprosy endemicity and burden at (sub)national level. Methods We used a mixed-method approach combining findings from a systematic literature review and a Delphi survey. The literature search was conducted in seven databases, searching for endemicity, burden and leprosy. We reviewed the available evidence on the usage of indicators, classification levels, and scoring methods to measure and classify endemicity and burden. A two round Delphi survey was conducted to ask experts to rank and weigh indicators, classification levels, and scoring methods. Results The literature review showed variation of indicators, levels, and cut-off values to measure leprosy endemicity and/or burden. The most used indicators for endemicity include new case detection rate (NCDR), new cases among children and new cases with grade 2 disability. For burden these include NCDR, MB cases, and prevalence. The classification levels 'high' and 'low' were most important. It was considered most relevant to use separate scoring methods for endemicity and burden. The scores would be derived by use of multiple indicators. Conclusion There is great variation in the existing method for measuring endemicity and burden across countries and regions. Our findings contribute to establishing a standardized uniform approach to measure and classify leprosy endemicity and burden at (sub)national level, which would allow effective communication and planning of intervention strategies. |
format |
Article in Journal/Newspaper |
author |
Dorcas O Ogunsumi Vivek Lal Karl Philipp Puchner Wim van Brakel Eva-Maria Schwienhorst-Stich Christa Kasang Joseph Chukwu Saskia Kreibich Sandra Parisi Jan Hendrik Richardus David J Blok |
author_facet |
Dorcas O Ogunsumi Vivek Lal Karl Philipp Puchner Wim van Brakel Eva-Maria Schwienhorst-Stich Christa Kasang Joseph Chukwu Saskia Kreibich Sandra Parisi Jan Hendrik Richardus David J Blok |
author_sort |
Dorcas O Ogunsumi |
title |
Measuring endemicity and burden of leprosy across countries and regions: A systematic review and Delphi survey. |
title_short |
Measuring endemicity and burden of leprosy across countries and regions: A systematic review and Delphi survey. |
title_full |
Measuring endemicity and burden of leprosy across countries and regions: A systematic review and Delphi survey. |
title_fullStr |
Measuring endemicity and burden of leprosy across countries and regions: A systematic review and Delphi survey. |
title_full_unstemmed |
Measuring endemicity and burden of leprosy across countries and regions: A systematic review and Delphi survey. |
title_sort |
measuring endemicity and burden of leprosy across countries and regions: a systematic review and delphi survey. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009769 https://doaj.org/article/86b778bcff58484a8dc39b513a3f11fb |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009769 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009769 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009769 https://doaj.org/article/86b778bcff58484a8dc39b513a3f11fb |
op_doi |
https://doi.org/10.1371/journal.pntd.0009769 |
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PLOS Neglected Tropical Diseases |
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15 |
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9 |
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e0009769 |
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