Humoral responses to the CoronoVac vaccine in healthcare workers
ABSTRACT Background: This study aimed to assess the immunoglobulin G (IgG) antibody response rate in emergency department (ED) healthcare workers (HCWs) and potential adverse effects after CoronaVac vaccination. Methods: All included HCWs were grouped based on the previous history of coronavirus dis...
Published in: | Revista da Sociedade Brasileira de Medicina Tropical |
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Sociedade Brasileira de Medicina Tropical (SBMT)
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Online Access: | https://doi.org/10.1590/0037-8682-0209-2022 https://doaj.org/article/86955d3d1d0b4a22b083eeb5c5a8b41c |
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ftdoajarticles:oai:doaj.org/article:86955d3d1d0b4a22b083eeb5c5a8b41c 2023-05-15T15:09:55+02:00 Humoral responses to the CoronoVac vaccine in healthcare workers Gokhan Eyupoglu Ramazan Guven Nuran Karabulut Adem Cakir Kemal Sener Burcu Genc Yavuz Davut Tekyol Akkan Avci 2023-02-01T00:00:00Z https://doi.org/10.1590/0037-8682-0209-2022 https://doaj.org/article/86955d3d1d0b4a22b083eeb5c5a8b41c EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822023000100310&lng=en&tlng=en http://www.scielo.br/pdf/rsbmt/v56/1678-9849-rsbmt-56-e0209-2022.pdf https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0209-2022 https://doaj.org/article/86955d3d1d0b4a22b083eeb5c5a8b41c Revista da Sociedade Brasileira de Medicina Tropical, Vol 56 (2023) CoronaVac Healthcare workers Immunization Arctic medicine. Tropical medicine RC955-962 article 2023 ftdoajarticles https://doi.org/10.1590/0037-8682-0209-2022 2023-02-26T01:39:23Z ABSTRACT Background: This study aimed to assess the immunoglobulin G (IgG) antibody response rate in emergency department (ED) healthcare workers (HCWs) and potential adverse effects after CoronaVac vaccination. Methods: All included HCWs were grouped based on the previous history of coronavirus disease 2019 (COVID-19) and the number of vaccinations. Furthermore, the IgG antibody response was evaluated based on the sex and smoking status of HCWs. Those with a cut-off index of ≥1.00 after vaccination with CoronaVac were considered to have had COVID-19 and had an adequate humoral response. Results: Among 224 ED HCWs, 18% experienced the adverse effects of CoronaVac vaccine, the most prevalent being pain in the injection site. The IgG antibody response rate was 20% after the first dose of vaccine, while the response rate increased to 90% after the second dose. Female HCWs had higher IgG response rates compared with male HCWs (53.8 [15.9-147.0] vs 31.2 [4.5-124.0]). Non-smokers had higher IgG response rate compared with smokers (49.0 [11.5-160.5] vs 23.1 [7.4-98.5]). Conclusion: A single dose of CoronaVac does not produce a sufficient antibody response; hence, two doses are recommended. Men have a lower IgG response compared with women. Smokers had a lower IgG response rate compared with non-smokers. Therefore, it may be necessary to carefully assess the humoral responses of men and smokers when implementing a community vaccination program. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 56 |
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Directory of Open Access Journals: DOAJ Articles |
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CoronaVac Healthcare workers Immunization Arctic medicine. Tropical medicine RC955-962 |
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CoronaVac Healthcare workers Immunization Arctic medicine. Tropical medicine RC955-962 Gokhan Eyupoglu Ramazan Guven Nuran Karabulut Adem Cakir Kemal Sener Burcu Genc Yavuz Davut Tekyol Akkan Avci Humoral responses to the CoronoVac vaccine in healthcare workers |
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CoronaVac Healthcare workers Immunization Arctic medicine. Tropical medicine RC955-962 |
description |
ABSTRACT Background: This study aimed to assess the immunoglobulin G (IgG) antibody response rate in emergency department (ED) healthcare workers (HCWs) and potential adverse effects after CoronaVac vaccination. Methods: All included HCWs were grouped based on the previous history of coronavirus disease 2019 (COVID-19) and the number of vaccinations. Furthermore, the IgG antibody response was evaluated based on the sex and smoking status of HCWs. Those with a cut-off index of ≥1.00 after vaccination with CoronaVac were considered to have had COVID-19 and had an adequate humoral response. Results: Among 224 ED HCWs, 18% experienced the adverse effects of CoronaVac vaccine, the most prevalent being pain in the injection site. The IgG antibody response rate was 20% after the first dose of vaccine, while the response rate increased to 90% after the second dose. Female HCWs had higher IgG response rates compared with male HCWs (53.8 [15.9-147.0] vs 31.2 [4.5-124.0]). Non-smokers had higher IgG response rate compared with smokers (49.0 [11.5-160.5] vs 23.1 [7.4-98.5]). Conclusion: A single dose of CoronaVac does not produce a sufficient antibody response; hence, two doses are recommended. Men have a lower IgG response compared with women. Smokers had a lower IgG response rate compared with non-smokers. Therefore, it may be necessary to carefully assess the humoral responses of men and smokers when implementing a community vaccination program. |
format |
Article in Journal/Newspaper |
author |
Gokhan Eyupoglu Ramazan Guven Nuran Karabulut Adem Cakir Kemal Sener Burcu Genc Yavuz Davut Tekyol Akkan Avci |
author_facet |
Gokhan Eyupoglu Ramazan Guven Nuran Karabulut Adem Cakir Kemal Sener Burcu Genc Yavuz Davut Tekyol Akkan Avci |
author_sort |
Gokhan Eyupoglu |
title |
Humoral responses to the CoronoVac vaccine in healthcare workers |
title_short |
Humoral responses to the CoronoVac vaccine in healthcare workers |
title_full |
Humoral responses to the CoronoVac vaccine in healthcare workers |
title_fullStr |
Humoral responses to the CoronoVac vaccine in healthcare workers |
title_full_unstemmed |
Humoral responses to the CoronoVac vaccine in healthcare workers |
title_sort |
humoral responses to the coronovac vaccine in healthcare workers |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2023 |
url |
https://doi.org/10.1590/0037-8682-0209-2022 https://doaj.org/article/86955d3d1d0b4a22b083eeb5c5a8b41c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 56 (2023) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822023000100310&lng=en&tlng=en http://www.scielo.br/pdf/rsbmt/v56/1678-9849-rsbmt-56-e0209-2022.pdf https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0209-2022 https://doaj.org/article/86955d3d1d0b4a22b083eeb5c5a8b41c |
op_doi |
https://doi.org/10.1590/0037-8682-0209-2022 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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56 |
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