Immunopathology of rabies infection in mice selected for high or low acute inflammatory reaction
Rabies is a severe and lethal disease that produces a slight inflammatory response during the infection process. We analyzed the immunopathological mechanisms that occur in the central nervous system (CNS) using mice genetically selected for maximal or minimal acute inflammatory reaction (AIRmax or...
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ftdoajarticles:oai:doaj.org/article:8690f88541964a22b24a96eb210465ea 2023-05-15T15:07:28+02:00 Immunopathology of rabies infection in mice selected for high or low acute inflammatory reaction S. M. Achkar I. L. Sinhorini O. G. Ribeiro M. L. Carrieri R. S. Ceretta C. A. Consales 2007-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992007000100003 https://doaj.org/article/8690f88541964a22b24a96eb210465ea EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000100003 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992007000100003 1678-9199 https://doaj.org/article/8690f88541964a22b24a96eb210465ea Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 13, Iss 1, Pp 39-55 (2007) rabies virus replication pathology inflammation immunoglobulin isotypes Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2007 ftdoajarticles https://doi.org/10.1590/S1678-91992007000100003 2022-12-30T23:00:57Z Rabies is a severe and lethal disease that produces a slight inflammatory response during the infection process. We analyzed the immunopathological mechanisms that occur in the central nervous system (CNS) using mice genetically selected for maximal or minimal acute inflammatory reaction (AIRmax or AIRmin). As viral samples, we adopted the antigenic variant 3 (AgV3) of rabies virus from hematophagous bats and a fixed virus strain (PV1 43/3). Titration of specific antibodies was performed using enzyme-linked immunosorbent assay (ELISA). We observed a slight increase in IgG and IgG1 isotypes in infected AIRmax mice. Incubation period, determined by intracerebral inoculation with 100 LD50, was 6-7 days for PV1 43/4 strain and 9-10 days for AgV3. No difference in viral replication was noticed between AIRmax and AIRmin mice. Mortality was 100% with both viral strains. Histopathological analysis of brains and spinal cords showed inflammatory foci in all regions of the CNS. No differences were noticed in the number of neutrophils. Negri bodies were observed in practically all sites analyzed. Results suggested that inflammatory reaction is not a determining factor in the susceptibility to rabies infection. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 13 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
rabies virus replication pathology inflammation immunoglobulin isotypes Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
rabies virus replication pathology inflammation immunoglobulin isotypes Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 S. M. Achkar I. L. Sinhorini O. G. Ribeiro M. L. Carrieri R. S. Ceretta C. A. Consales Immunopathology of rabies infection in mice selected for high or low acute inflammatory reaction |
topic_facet |
rabies virus replication pathology inflammation immunoglobulin isotypes Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Rabies is a severe and lethal disease that produces a slight inflammatory response during the infection process. We analyzed the immunopathological mechanisms that occur in the central nervous system (CNS) using mice genetically selected for maximal or minimal acute inflammatory reaction (AIRmax or AIRmin). As viral samples, we adopted the antigenic variant 3 (AgV3) of rabies virus from hematophagous bats and a fixed virus strain (PV1 43/3). Titration of specific antibodies was performed using enzyme-linked immunosorbent assay (ELISA). We observed a slight increase in IgG and IgG1 isotypes in infected AIRmax mice. Incubation period, determined by intracerebral inoculation with 100 LD50, was 6-7 days for PV1 43/4 strain and 9-10 days for AgV3. No difference in viral replication was noticed between AIRmax and AIRmin mice. Mortality was 100% with both viral strains. Histopathological analysis of brains and spinal cords showed inflammatory foci in all regions of the CNS. No differences were noticed in the number of neutrophils. Negri bodies were observed in practically all sites analyzed. Results suggested that inflammatory reaction is not a determining factor in the susceptibility to rabies infection. |
format |
Article in Journal/Newspaper |
author |
S. M. Achkar I. L. Sinhorini O. G. Ribeiro M. L. Carrieri R. S. Ceretta C. A. Consales |
author_facet |
S. M. Achkar I. L. Sinhorini O. G. Ribeiro M. L. Carrieri R. S. Ceretta C. A. Consales |
author_sort |
S. M. Achkar |
title |
Immunopathology of rabies infection in mice selected for high or low acute inflammatory reaction |
title_short |
Immunopathology of rabies infection in mice selected for high or low acute inflammatory reaction |
title_full |
Immunopathology of rabies infection in mice selected for high or low acute inflammatory reaction |
title_fullStr |
Immunopathology of rabies infection in mice selected for high or low acute inflammatory reaction |
title_full_unstemmed |
Immunopathology of rabies infection in mice selected for high or low acute inflammatory reaction |
title_sort |
immunopathology of rabies infection in mice selected for high or low acute inflammatory reaction |
publisher |
SciELO |
publishDate |
2007 |
url |
https://doi.org/10.1590/S1678-91992007000100003 https://doaj.org/article/8690f88541964a22b24a96eb210465ea |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 13, Iss 1, Pp 39-55 (2007) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000100003 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992007000100003 1678-9199 https://doaj.org/article/8690f88541964a22b24a96eb210465ea |
op_doi |
https://doi.org/10.1590/S1678-91992007000100003 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
13 |
container_issue |
1 |
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1766338969416499200 |