Post-dengue acute disseminated encephalomyelitis: A case report and meta-analysis.
Dengue is one of the most common infectious diseases. The aim of this study was to systematically review acute disseminated encephalomyelitis (ADEM) and to represent a new case.We searched for articles in nine databases for case reports, series or previous reviews reporting ADEM cases in human. We u...
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ftdoajarticles:oai:doaj.org/article:86854cc1a2794b51907155a6fc3e0314 2023-05-15T15:13:34+02:00 Post-dengue acute disseminated encephalomyelitis: A case report and meta-analysis. Mohamed Gomaa Kamel Nguyen Tran Nam Nguyen Huu Bao Han Abd-Elaziz El-Shabouny Abd-ElRahman Mohamed Makram Fatma Abd-Elshahed Abd-Elhay Tran Ngoc Dang Nguyen Le Trung Hieu Vu Thi Que Huong Trinh Huu Tung Kenji Hirayama Nguyen Tien Huy 2017-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005715 https://doaj.org/article/86854cc1a2794b51907155a6fc3e0314 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5509372?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005715 https://doaj.org/article/86854cc1a2794b51907155a6fc3e0314 PLoS Neglected Tropical Diseases, Vol 11, Iss 6, p e0005715 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005715 2022-12-31T12:11:29Z Dengue is one of the most common infectious diseases. The aim of this study was to systematically review acute disseminated encephalomyelitis (ADEM) and to represent a new case.We searched for articles in nine databases for case reports, series or previous reviews reporting ADEM cases in human. We used Fisher's exact and Mann-Whitney U tests. Classification trees were used to find the predictors of the disease outcomes. We combined findings using fixed- and random-effects models. A 13-year-old girl was admitted to the hospital due to fever. She has a urinary retention. The neurological examinations revealed that she became lethargic and quadriplegic. She had upper limbs weakness and lower limbs complete paraplegia. Her status gradually improved after the treatment. She was nearly intact with the proximal part of her legs had a mild weakness in discharge. The prevalence of ADEM among dengue patients was 0.4% [95% confidence intervals (95% CI) 0.1-2.5%], all neurological disorders among dengue was 2.6% [95% CI 1.8-3.8%], and ADEM among neurological disorders was 6.8% [95% CI 3.4-13%]. The most frequent manifestation of ADEM was altered sensorium/consciousness (58%), seizures and urination problems (35%), vision problems (31%), slurred speech (23%), walk problems (15%) then ataxia (12%). There was a significant difference between cases having complete recovery or bad outcomes in the onset day of neurological manifestations being earlier and in temperature being higher in cases having bad outcomes (p-value < 0.05). This was confirmed by classification trees which included these two variables.The prevalence of ADEM among dengue and other dengue-related neurological disorders is not too rare. The high fever of ADEM cases at admission and earlier onset day of neurological manifestations are associated with the bad outcomes. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 6 e0005715 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Mohamed Gomaa Kamel Nguyen Tran Nam Nguyen Huu Bao Han Abd-Elaziz El-Shabouny Abd-ElRahman Mohamed Makram Fatma Abd-Elshahed Abd-Elhay Tran Ngoc Dang Nguyen Le Trung Hieu Vu Thi Que Huong Trinh Huu Tung Kenji Hirayama Nguyen Tien Huy Post-dengue acute disseminated encephalomyelitis: A case report and meta-analysis. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Dengue is one of the most common infectious diseases. The aim of this study was to systematically review acute disseminated encephalomyelitis (ADEM) and to represent a new case.We searched for articles in nine databases for case reports, series or previous reviews reporting ADEM cases in human. We used Fisher's exact and Mann-Whitney U tests. Classification trees were used to find the predictors of the disease outcomes. We combined findings using fixed- and random-effects models. A 13-year-old girl was admitted to the hospital due to fever. She has a urinary retention. The neurological examinations revealed that she became lethargic and quadriplegic. She had upper limbs weakness and lower limbs complete paraplegia. Her status gradually improved after the treatment. She was nearly intact with the proximal part of her legs had a mild weakness in discharge. The prevalence of ADEM among dengue patients was 0.4% [95% confidence intervals (95% CI) 0.1-2.5%], all neurological disorders among dengue was 2.6% [95% CI 1.8-3.8%], and ADEM among neurological disorders was 6.8% [95% CI 3.4-13%]. The most frequent manifestation of ADEM was altered sensorium/consciousness (58%), seizures and urination problems (35%), vision problems (31%), slurred speech (23%), walk problems (15%) then ataxia (12%). There was a significant difference between cases having complete recovery or bad outcomes in the onset day of neurological manifestations being earlier and in temperature being higher in cases having bad outcomes (p-value < 0.05). This was confirmed by classification trees which included these two variables.The prevalence of ADEM among dengue and other dengue-related neurological disorders is not too rare. The high fever of ADEM cases at admission and earlier onset day of neurological manifestations are associated with the bad outcomes. |
format |
Article in Journal/Newspaper |
author |
Mohamed Gomaa Kamel Nguyen Tran Nam Nguyen Huu Bao Han Abd-Elaziz El-Shabouny Abd-ElRahman Mohamed Makram Fatma Abd-Elshahed Abd-Elhay Tran Ngoc Dang Nguyen Le Trung Hieu Vu Thi Que Huong Trinh Huu Tung Kenji Hirayama Nguyen Tien Huy |
author_facet |
Mohamed Gomaa Kamel Nguyen Tran Nam Nguyen Huu Bao Han Abd-Elaziz El-Shabouny Abd-ElRahman Mohamed Makram Fatma Abd-Elshahed Abd-Elhay Tran Ngoc Dang Nguyen Le Trung Hieu Vu Thi Que Huong Trinh Huu Tung Kenji Hirayama Nguyen Tien Huy |
author_sort |
Mohamed Gomaa Kamel |
title |
Post-dengue acute disseminated encephalomyelitis: A case report and meta-analysis. |
title_short |
Post-dengue acute disseminated encephalomyelitis: A case report and meta-analysis. |
title_full |
Post-dengue acute disseminated encephalomyelitis: A case report and meta-analysis. |
title_fullStr |
Post-dengue acute disseminated encephalomyelitis: A case report and meta-analysis. |
title_full_unstemmed |
Post-dengue acute disseminated encephalomyelitis: A case report and meta-analysis. |
title_sort |
post-dengue acute disseminated encephalomyelitis: a case report and meta-analysis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005715 https://doaj.org/article/86854cc1a2794b51907155a6fc3e0314 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 6, p e0005715 (2017) |
op_relation |
http://europepmc.org/articles/PMC5509372?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005715 https://doaj.org/article/86854cc1a2794b51907155a6fc3e0314 |
op_doi |
https://doi.org/10.1371/journal.pntd.0005715 |
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PLOS Neglected Tropical Diseases |
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11 |
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6 |
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e0005715 |
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