Mycobacterium tuberculosis spoligotypes and drug-resistant characterization from Beira compared to genotypes circulating in Mozambique

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Lívia Maria Pala Anselmo, Emilyn Costa Conceição, Evangelina Namburete, Cinara Feliciano, Silvana Spindola, Christophe Sola, Valdes Roberto Bollela
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2019
• Subjects: Genotyping; Spoligotyping; Tuberculosis; Arctic medicine. Tropical medicine; RC955-962; Arctic; Indian
• Online Access: https://doi.org/10.1590/0037-8682-0257-2019; https://doaj.org/article/8657be3fb5ea4c03bb7f08ce42e435f4

Abstract INTRODUCTION Mozambique is one of three countries with high prevalence of tuberculosis (TB), TB/human immunodeficiency virus coinfection, and multidrug-resistant TB. We aimed to describe Mycobacterium tuberculosis spoligotypes circulating among drug resistant (DR) strains from Beira, Mozambique comparing them with genotypes in the country. METHODS: We performed spoligotyping of 79 M. tuberculosis suspected of DR-TB compared all spoligotype patterns published on the international database and PubMed. RESULTS: Both in Beira and Mozambique (n=578), the main clades were Latin-American-Mediterranean, East-African-Indian, Beijing and T, with no extensively DR TB cases. CONCLUSIONS: Beira and Mozambique share the same population genetic structure of M. tuberculosis.