Study of Alkylglycerol Containing Shark Liver Oil: A Physico Chemical Support for Biological Effect?
Shark liver oil (SLO), is used in natural medicine as immunity stimulant, cardiovascular protector and anti ageing reagent. These properties were related with the high amounts of alkylglycerols (22%) obtained from Greenland shark liver. After a control of the mean SLO composition by NMR and MS, surf...
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ftdoajarticles:oai:doaj.org/article:85f8511cd6a443d8b1e15554ce958dde 2023-05-15T16:29:04+02:00 Study of Alkylglycerol Containing Shark Liver Oil: A Physico Chemical Support for Biological Effect? Jean-Claude Debouzy David Crouzier Bertrand Lefebvre Vincent Dabouis 2008-01-01T00:00:00Z https://doi.org/10.4137/DTI.S671 https://doaj.org/article/85f8511cd6a443d8b1e15554ce958dde EN eng AboutScience Srl https://doi.org/10.4137/DTI.S671 https://doaj.org/toc/1177-3928 1177-3928 doi:10.4137/DTI.S671 https://doaj.org/article/85f8511cd6a443d8b1e15554ce958dde Drug Target Insights, Vol 3 (2008) Therapeutics. Pharmacology RM1-950 article 2008 ftdoajarticles https://doi.org/10.4137/DTI.S671 2022-12-31T16:35:19Z Shark liver oil (SLO), is used in natural medicine as immunity stimulant, cardiovascular protector and anti ageing reagent. These properties were related with the high amounts of alkylglycerols (22%) obtained from Greenland shark liver. After a control of the mean SLO composition by NMR and MS, surface and membrane interactions and antioxidant properties were investigated using NMR, ESR and ST measurements and the in vitro consequences on erythrocytes and cells were studied. An estimation of the composition of this extract was performed. Moreover, SLO was found not haemolytic (A concentration inducing 50% haemolysis, HC 50 could not be reached) and superficial tension measurements revealed slight tension active properties. The 31 P and 2 H-NMR and ESR studies of phospholipid dispersions (dimyristoyl phosphatidyl cholin, DMPC) in the presence of SLO showed a significant increase in membrane fluidity at low temperature (below phase transition temperature) predominantly observed at the surface level. The anti oxidant activity was also confirmed, similar as that observed for vitamin E. Article in Journal/Newspaper Greenland Directory of Open Access Journals: DOAJ Articles Greenland Protector ENVELOPE(-66.217,-66.217,-66.717,-66.717) Drug Target Insights 3 DTI.S671 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Therapeutics. Pharmacology RM1-950 |
spellingShingle |
Therapeutics. Pharmacology RM1-950 Jean-Claude Debouzy David Crouzier Bertrand Lefebvre Vincent Dabouis Study of Alkylglycerol Containing Shark Liver Oil: A Physico Chemical Support for Biological Effect? |
topic_facet |
Therapeutics. Pharmacology RM1-950 |
description |
Shark liver oil (SLO), is used in natural medicine as immunity stimulant, cardiovascular protector and anti ageing reagent. These properties were related with the high amounts of alkylglycerols (22%) obtained from Greenland shark liver. After a control of the mean SLO composition by NMR and MS, surface and membrane interactions and antioxidant properties were investigated using NMR, ESR and ST measurements and the in vitro consequences on erythrocytes and cells were studied. An estimation of the composition of this extract was performed. Moreover, SLO was found not haemolytic (A concentration inducing 50% haemolysis, HC 50 could not be reached) and superficial tension measurements revealed slight tension active properties. The 31 P and 2 H-NMR and ESR studies of phospholipid dispersions (dimyristoyl phosphatidyl cholin, DMPC) in the presence of SLO showed a significant increase in membrane fluidity at low temperature (below phase transition temperature) predominantly observed at the surface level. The anti oxidant activity was also confirmed, similar as that observed for vitamin E. |
format |
Article in Journal/Newspaper |
author |
Jean-Claude Debouzy David Crouzier Bertrand Lefebvre Vincent Dabouis |
author_facet |
Jean-Claude Debouzy David Crouzier Bertrand Lefebvre Vincent Dabouis |
author_sort |
Jean-Claude Debouzy |
title |
Study of Alkylglycerol Containing Shark Liver Oil: A Physico Chemical Support for Biological Effect? |
title_short |
Study of Alkylglycerol Containing Shark Liver Oil: A Physico Chemical Support for Biological Effect? |
title_full |
Study of Alkylglycerol Containing Shark Liver Oil: A Physico Chemical Support for Biological Effect? |
title_fullStr |
Study of Alkylglycerol Containing Shark Liver Oil: A Physico Chemical Support for Biological Effect? |
title_full_unstemmed |
Study of Alkylglycerol Containing Shark Liver Oil: A Physico Chemical Support for Biological Effect? |
title_sort |
study of alkylglycerol containing shark liver oil: a physico chemical support for biological effect? |
publisher |
AboutScience Srl |
publishDate |
2008 |
url |
https://doi.org/10.4137/DTI.S671 https://doaj.org/article/85f8511cd6a443d8b1e15554ce958dde |
long_lat |
ENVELOPE(-66.217,-66.217,-66.717,-66.717) |
geographic |
Greenland Protector |
geographic_facet |
Greenland Protector |
genre |
Greenland |
genre_facet |
Greenland |
op_source |
Drug Target Insights, Vol 3 (2008) |
op_relation |
https://doi.org/10.4137/DTI.S671 https://doaj.org/toc/1177-3928 1177-3928 doi:10.4137/DTI.S671 https://doaj.org/article/85f8511cd6a443d8b1e15554ce958dde |
op_doi |
https://doi.org/10.4137/DTI.S671 |
container_title |
Drug Target Insights |
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3 |
container_start_page |
DTI.S671 |
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1766018756361846784 |