Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis
Literature reports the chemical constituent yields of electronic nicotine delivery systems (ENDS) aerosol collected using a range of aerosol collection strategies. The number of puffs to deplete an ENDS product varies widely, but collections often consist of data from the first 50–100 puffs. However...
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ftdoajarticles:oai:doaj.org/article:85c13905fd0145cf99e65acc149bd804 2023-10-09T21:51:03+02:00 Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis J. Brian Jameson Jiaming Wang Patrick C. Bailey Michael J. Oldham Cameron R. Smith Lena N. Jeong David K. Cook Austin L. Bates Sifat Ullah Alexander S. C. Pennington I. Gene Gillman 2023-09-01T00:00:00Z https://doi.org/10.3389/fchem.2023.1223967 https://doaj.org/article/85c13905fd0145cf99e65acc149bd804 EN eng Frontiers Media S.A. https://www.frontiersin.org/articles/10.3389/fchem.2023.1223967/full https://doaj.org/toc/2296-2646 2296-2646 doi:10.3389/fchem.2023.1223967 https://doaj.org/article/85c13905fd0145cf99e65acc149bd804 Frontiers in Chemistry, Vol 11 (2023) ENDS nicotine tobacco carbonyls formaldehyde metals Chemistry QD1-999 article 2023 ftdoajarticles https://doi.org/10.3389/fchem.2023.1223967 2023-09-10T00:35:48Z Literature reports the chemical constituent yields of electronic nicotine delivery systems (ENDS) aerosol collected using a range of aerosol collection strategies. The number of puffs to deplete an ENDS product varies widely, but collections often consist of data from the first 50–100 puffs. However, it is not clear whether these discrete puff blocks are representative of constituent yields over the life of a pod. We aimed to assess the effect of differing aerosol collection strategies on reported yields for select chemical constituents in the aerosol of closed pod-based ENDS products. Constituents analyzed were chosen to reflect important classes of compounds from the Final Premarket Tobacco Product Application Guidance. Yields were normalized to total device mass loss (DML). Collection strategies that consisted of partial pod collection were valid for determining yields of constituents whose DML normalized yields were consistent for the duration of pod life. These included primary aerosol constituents, such as propylene glycol, glycerol, and nicotine, and whole pod yields could be determined from initial puff blocks. However, changes were observed in the yields of some metals, some carbonyl compounds, and glycidol over pod life in a chemical constituent and product dependent manner. These results suggest that collection strategies consisting of initial puff block collections require validation per chemical constituent/product and are not appropriate for chemical constituents with variable yields over pod life. Whole pod collection increased sensitivity and accuracy in determining metal, carbonyl, and glycidol yields compared to puff block-based collection methodologies for all products tested. Article in Journal/Newspaper DML Directory of Open Access Journals: DOAJ Articles Frontiers in Chemistry 11 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
ENDS nicotine tobacco carbonyls formaldehyde metals Chemistry QD1-999 |
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ENDS nicotine tobacco carbonyls formaldehyde metals Chemistry QD1-999 J. Brian Jameson Jiaming Wang Patrick C. Bailey Michael J. Oldham Cameron R. Smith Lena N. Jeong David K. Cook Austin L. Bates Sifat Ullah Alexander S. C. Pennington I. Gene Gillman Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis |
topic_facet |
ENDS nicotine tobacco carbonyls formaldehyde metals Chemistry QD1-999 |
description |
Literature reports the chemical constituent yields of electronic nicotine delivery systems (ENDS) aerosol collected using a range of aerosol collection strategies. The number of puffs to deplete an ENDS product varies widely, but collections often consist of data from the first 50–100 puffs. However, it is not clear whether these discrete puff blocks are representative of constituent yields over the life of a pod. We aimed to assess the effect of differing aerosol collection strategies on reported yields for select chemical constituents in the aerosol of closed pod-based ENDS products. Constituents analyzed were chosen to reflect important classes of compounds from the Final Premarket Tobacco Product Application Guidance. Yields were normalized to total device mass loss (DML). Collection strategies that consisted of partial pod collection were valid for determining yields of constituents whose DML normalized yields were consistent for the duration of pod life. These included primary aerosol constituents, such as propylene glycol, glycerol, and nicotine, and whole pod yields could be determined from initial puff blocks. However, changes were observed in the yields of some metals, some carbonyl compounds, and glycidol over pod life in a chemical constituent and product dependent manner. These results suggest that collection strategies consisting of initial puff block collections require validation per chemical constituent/product and are not appropriate for chemical constituents with variable yields over pod life. Whole pod collection increased sensitivity and accuracy in determining metal, carbonyl, and glycidol yields compared to puff block-based collection methodologies for all products tested. |
format |
Article in Journal/Newspaper |
author |
J. Brian Jameson Jiaming Wang Patrick C. Bailey Michael J. Oldham Cameron R. Smith Lena N. Jeong David K. Cook Austin L. Bates Sifat Ullah Alexander S. C. Pennington I. Gene Gillman |
author_facet |
J. Brian Jameson Jiaming Wang Patrick C. Bailey Michael J. Oldham Cameron R. Smith Lena N. Jeong David K. Cook Austin L. Bates Sifat Ullah Alexander S. C. Pennington I. Gene Gillman |
author_sort |
J. Brian Jameson |
title |
Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis |
title_short |
Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis |
title_full |
Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis |
title_fullStr |
Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis |
title_full_unstemmed |
Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis |
title_sort |
determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis |
publisher |
Frontiers Media S.A. |
publishDate |
2023 |
url |
https://doi.org/10.3389/fchem.2023.1223967 https://doaj.org/article/85c13905fd0145cf99e65acc149bd804 |
genre |
DML |
genre_facet |
DML |
op_source |
Frontiers in Chemistry, Vol 11 (2023) |
op_relation |
https://www.frontiersin.org/articles/10.3389/fchem.2023.1223967/full https://doaj.org/toc/2296-2646 2296-2646 doi:10.3389/fchem.2023.1223967 https://doaj.org/article/85c13905fd0145cf99e65acc149bd804 |
op_doi |
https://doi.org/10.3389/fchem.2023.1223967 |
container_title |
Frontiers in Chemistry |
container_volume |
11 |
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1779314145198342144 |