Prevalence of Haemophilus influenzae in the nasopharynx of children from regions with varying incidence of invasive H. influenzae serotype a disease: Canadian Immunization Research Network (CIRN) study
Haemophilus influenzae serotype a (Hia) has recently emerged as an important cause of invasive disease in the North American Arctic and Sub-Arctic regions, mainly affecting young Indigenous children. In this study, we addressed the question of whether the prevalence of Hia and all H. influenzae in t...
Published in: | International Journal of Circumpolar Health |
---|---|
Main Authors: | , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Taylor & Francis Group
2024
|
Subjects: | |
Online Access: | https://doi.org/10.1080/22423982.2024.2371111 https://doaj.org/article/859329eee6c74d6d85ba6f20c1bf72f9 |
id |
ftdoajarticles:oai:doaj.org/article:859329eee6c74d6d85ba6f20c1bf72f9 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:859329eee6c74d6d85ba6f20c1bf72f9 2024-09-15T18:02:08+00:00 Prevalence of Haemophilus influenzae in the nasopharynx of children from regions with varying incidence of invasive H. influenzae serotype a disease: Canadian Immunization Research Network (CIRN) study Marina Ulanova Raymond SW Tsang David M. Goldfarb Marek Smieja Brenda Huska Kathy Luinstra Nicole Le Saux 2024-12-01T00:00:00Z https://doi.org/10.1080/22423982.2024.2371111 https://doaj.org/article/859329eee6c74d6d85ba6f20c1bf72f9 EN eng Taylor & Francis Group https://www.tandfonline.com/doi/10.1080/22423982.2024.2371111 https://doaj.org/toc/2242-3982 doi:10.1080/22423982.2024.2371111 2242-3982 https://doaj.org/article/859329eee6c74d6d85ba6f20c1bf72f9 International Journal of Circumpolar Health, Vol 83, Iss 1 (2024) Haemophilus influenzae serotype a children acute respiratory tract infections nasopharyngeal swabs Arctic medicine. Tropical medicine RC955-962 article 2024 ftdoajarticles https://doi.org/10.1080/22423982.2024.2371111 2024-08-05T17:49:04Z Haemophilus influenzae serotype a (Hia) has recently emerged as an important cause of invasive disease in the North American Arctic and Sub-Arctic regions, mainly affecting young Indigenous children. In this study, we addressed the question of whether the prevalence of Hia and all H. influenzae in the nasopharynx differed between paediatric populations from regions with high versus low incidence of invasive Hia disease. Nasopharyngeal specimens from children with acute respiratory tract infections (ARTI) collected for routine diagnostic detection of respiratory viruses were analysed with molecular-genetic methods to identify and serotype H. influenzae. In Nunavut, a region with a high incidence of invasive Hia disease, all H. influenzae and particularly Hia were found in the nasopharynx of 60.6% and 3.0% children. In Southern Ontario (Hamilton region), where Hia invasive disease is rare, the frequencies of all H. influenzae and Hia detection were 38.5% and 0.6%, respectively. In both cohorts, non-typeable H. influenzae was prevalent (57.0% and 37.9%, respectively). Considering that Hia is an important cause of severe invasive disease in Nunavut children, 3% prevalence of Hia among children with ARTI can reflect continuing circulation of the pathogen in the Northern communities that may result in invasive disease outbreaks. Article in Journal/Newspaper Circumpolar Health International Journal of Circumpolar Health Nunavut Directory of Open Access Journals: DOAJ Articles International Journal of Circumpolar Health 83 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Haemophilus influenzae serotype a children acute respiratory tract infections nasopharyngeal swabs Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Haemophilus influenzae serotype a children acute respiratory tract infections nasopharyngeal swabs Arctic medicine. Tropical medicine RC955-962 Marina Ulanova Raymond SW Tsang David M. Goldfarb Marek Smieja Brenda Huska Kathy Luinstra Nicole Le Saux Prevalence of Haemophilus influenzae in the nasopharynx of children from regions with varying incidence of invasive H. influenzae serotype a disease: Canadian Immunization Research Network (CIRN) study |
topic_facet |
Haemophilus influenzae serotype a children acute respiratory tract infections nasopharyngeal swabs Arctic medicine. Tropical medicine RC955-962 |
description |
Haemophilus influenzae serotype a (Hia) has recently emerged as an important cause of invasive disease in the North American Arctic and Sub-Arctic regions, mainly affecting young Indigenous children. In this study, we addressed the question of whether the prevalence of Hia and all H. influenzae in the nasopharynx differed between paediatric populations from regions with high versus low incidence of invasive Hia disease. Nasopharyngeal specimens from children with acute respiratory tract infections (ARTI) collected for routine diagnostic detection of respiratory viruses were analysed with molecular-genetic methods to identify and serotype H. influenzae. In Nunavut, a region with a high incidence of invasive Hia disease, all H. influenzae and particularly Hia were found in the nasopharynx of 60.6% and 3.0% children. In Southern Ontario (Hamilton region), where Hia invasive disease is rare, the frequencies of all H. influenzae and Hia detection were 38.5% and 0.6%, respectively. In both cohorts, non-typeable H. influenzae was prevalent (57.0% and 37.9%, respectively). Considering that Hia is an important cause of severe invasive disease in Nunavut children, 3% prevalence of Hia among children with ARTI can reflect continuing circulation of the pathogen in the Northern communities that may result in invasive disease outbreaks. |
format |
Article in Journal/Newspaper |
author |
Marina Ulanova Raymond SW Tsang David M. Goldfarb Marek Smieja Brenda Huska Kathy Luinstra Nicole Le Saux |
author_facet |
Marina Ulanova Raymond SW Tsang David M. Goldfarb Marek Smieja Brenda Huska Kathy Luinstra Nicole Le Saux |
author_sort |
Marina Ulanova |
title |
Prevalence of Haemophilus influenzae in the nasopharynx of children from regions with varying incidence of invasive H. influenzae serotype a disease: Canadian Immunization Research Network (CIRN) study |
title_short |
Prevalence of Haemophilus influenzae in the nasopharynx of children from regions with varying incidence of invasive H. influenzae serotype a disease: Canadian Immunization Research Network (CIRN) study |
title_full |
Prevalence of Haemophilus influenzae in the nasopharynx of children from regions with varying incidence of invasive H. influenzae serotype a disease: Canadian Immunization Research Network (CIRN) study |
title_fullStr |
Prevalence of Haemophilus influenzae in the nasopharynx of children from regions with varying incidence of invasive H. influenzae serotype a disease: Canadian Immunization Research Network (CIRN) study |
title_full_unstemmed |
Prevalence of Haemophilus influenzae in the nasopharynx of children from regions with varying incidence of invasive H. influenzae serotype a disease: Canadian Immunization Research Network (CIRN) study |
title_sort |
prevalence of haemophilus influenzae in the nasopharynx of children from regions with varying incidence of invasive h. influenzae serotype a disease: canadian immunization research network (cirn) study |
publisher |
Taylor & Francis Group |
publishDate |
2024 |
url |
https://doi.org/10.1080/22423982.2024.2371111 https://doaj.org/article/859329eee6c74d6d85ba6f20c1bf72f9 |
genre |
Circumpolar Health International Journal of Circumpolar Health Nunavut |
genre_facet |
Circumpolar Health International Journal of Circumpolar Health Nunavut |
op_source |
International Journal of Circumpolar Health, Vol 83, Iss 1 (2024) |
op_relation |
https://www.tandfonline.com/doi/10.1080/22423982.2024.2371111 https://doaj.org/toc/2242-3982 doi:10.1080/22423982.2024.2371111 2242-3982 https://doaj.org/article/859329eee6c74d6d85ba6f20c1bf72f9 |
op_doi |
https://doi.org/10.1080/22423982.2024.2371111 |
container_title |
International Journal of Circumpolar Health |
container_volume |
83 |
container_issue |
1 |
_version_ |
1810439379372474368 |