SPECIES- AND AGE-SPECIFIC CHARACTERISTICS OF THE LACTATE DEHYDROGENASE SYSTEM IN TISSUES OF RODENTS (MAMMALIA: RODENTIA)
The aim of this study was to analyze the species-specific features and age-related changes in the total lactate dehydrogenase activity (LDh, EC 1.1.1.27) and LDh patterns in some tissues in three species of rodents (Rodentia) with different ecological characteristics – the northern birch mouse Sicis...
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Karelian Research Centre of the Russian Academy of Sciences
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ftdoajarticles:oai:doaj.org/article:858d9f8925924c8282dfe11c75a40558 2023-05-15T18:40:02+02:00 SPECIES- AND AGE-SPECIFIC CHARACTERISTICS OF THE LACTATE DEHYDROGENASE SYSTEM IN TISSUES OF RODENTS (MAMMALIA: RODENTIA) Ekaterina Antonova Svetlana Sergina Victor Ilyukha Alina Yakimova 2018-04-01T00:00:00Z https://doi.org/10.17076/them809 https://doaj.org/article/858d9f8925924c8282dfe11c75a40558 EN RU eng rus Karelian Research Centre of the Russian Academy of Sciences http://journals.krc.karelia.ru/index.php/thematic/article/view/809 https://doaj.org/toc/1997-3217 https://doaj.org/toc/2312-4504 1997-3217 2312-4504 doi:10.17076/them809 https://doaj.org/article/858d9f8925924c8282dfe11c75a40558 Transactions of the Karelian Research Centre of the Russian Academy of Sciences, Iss 4 (2018) лактатдегидрогеназа изоферменты адаптация ныряние гибернация онтогенез Science Q article 2018 ftdoajarticles https://doi.org/10.17076/them809 2022-12-31T01:17:13Z The aim of this study was to analyze the species-specific features and age-related changes in the total lactate dehydrogenase activity (LDh, EC 1.1.1.27) and LDh patterns in some tissues in three species of rodents (Rodentia) with different ecological characteristics – the northern birch mouse Sicista betulina (Pallas, 1779), the European water vole Arvicola amphibius (L., 1758) and the tundra vole Microtus oeconomus (Pallas, 1776). Compared to the European water vole and the northern birch mouse, the tundra vole had a higher content of M-subunits and the amount of LDh-5 isoenzyme in the liver and skeletal muscles, higher contents of aerobic LDh-1 isoenzymes and, respectively, of h-subunits in kidneys and heart. In the heart and kidneys, the hybrid fractions (LDh-2, LDh-3, LDh-4) dominated over LDh-1 and LDh-5 in the northern birch mouse. The total LDh activity in the liver and kidneys of the northern birch mouse was higher than in the tundra vole. The extent of anaerobic ATP production in the liver of small rodents varied – the liver of the diving European water vole contained more LDh-2, LDh- 3, LDh-4 and h-subunits than the corresponding tissue in the non-diving tundra vole. In kidneys of the northern birch mouse and European water vole, the content of the LDh- 5 isoenzyme increased through the ontogeny. The LDh activity was higher in the heart of European water vole adults compared to young animals. Species-specific differences in LDh isoenzyme spectra and total LDh activity in the studied mammals reflect their adaptation to the semi-aquatic and hibernating lifestyles. Article in Journal/Newspaper Tundra Directory of Open Access Journals: DOAJ Articles Proceedings of the Karelian Research Centre of the Russian Academy of Sciences 4 3 |
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English Russian |
topic |
лактатдегидрогеназа изоферменты адаптация ныряние гибернация онтогенез Science Q |
spellingShingle |
лактатдегидрогеназа изоферменты адаптация ныряние гибернация онтогенез Science Q Ekaterina Antonova Svetlana Sergina Victor Ilyukha Alina Yakimova SPECIES- AND AGE-SPECIFIC CHARACTERISTICS OF THE LACTATE DEHYDROGENASE SYSTEM IN TISSUES OF RODENTS (MAMMALIA: RODENTIA) |
topic_facet |
лактатдегидрогеназа изоферменты адаптация ныряние гибернация онтогенез Science Q |
description |
The aim of this study was to analyze the species-specific features and age-related changes in the total lactate dehydrogenase activity (LDh, EC 1.1.1.27) and LDh patterns in some tissues in three species of rodents (Rodentia) with different ecological characteristics – the northern birch mouse Sicista betulina (Pallas, 1779), the European water vole Arvicola amphibius (L., 1758) and the tundra vole Microtus oeconomus (Pallas, 1776). Compared to the European water vole and the northern birch mouse, the tundra vole had a higher content of M-subunits and the amount of LDh-5 isoenzyme in the liver and skeletal muscles, higher contents of aerobic LDh-1 isoenzymes and, respectively, of h-subunits in kidneys and heart. In the heart and kidneys, the hybrid fractions (LDh-2, LDh-3, LDh-4) dominated over LDh-1 and LDh-5 in the northern birch mouse. The total LDh activity in the liver and kidneys of the northern birch mouse was higher than in the tundra vole. The extent of anaerobic ATP production in the liver of small rodents varied – the liver of the diving European water vole contained more LDh-2, LDh- 3, LDh-4 and h-subunits than the corresponding tissue in the non-diving tundra vole. In kidneys of the northern birch mouse and European water vole, the content of the LDh- 5 isoenzyme increased through the ontogeny. The LDh activity was higher in the heart of European water vole adults compared to young animals. Species-specific differences in LDh isoenzyme spectra and total LDh activity in the studied mammals reflect their adaptation to the semi-aquatic and hibernating lifestyles. |
format |
Article in Journal/Newspaper |
author |
Ekaterina Antonova Svetlana Sergina Victor Ilyukha Alina Yakimova |
author_facet |
Ekaterina Antonova Svetlana Sergina Victor Ilyukha Alina Yakimova |
author_sort |
Ekaterina Antonova |
title |
SPECIES- AND AGE-SPECIFIC CHARACTERISTICS OF THE LACTATE DEHYDROGENASE SYSTEM IN TISSUES OF RODENTS (MAMMALIA: RODENTIA) |
title_short |
SPECIES- AND AGE-SPECIFIC CHARACTERISTICS OF THE LACTATE DEHYDROGENASE SYSTEM IN TISSUES OF RODENTS (MAMMALIA: RODENTIA) |
title_full |
SPECIES- AND AGE-SPECIFIC CHARACTERISTICS OF THE LACTATE DEHYDROGENASE SYSTEM IN TISSUES OF RODENTS (MAMMALIA: RODENTIA) |
title_fullStr |
SPECIES- AND AGE-SPECIFIC CHARACTERISTICS OF THE LACTATE DEHYDROGENASE SYSTEM IN TISSUES OF RODENTS (MAMMALIA: RODENTIA) |
title_full_unstemmed |
SPECIES- AND AGE-SPECIFIC CHARACTERISTICS OF THE LACTATE DEHYDROGENASE SYSTEM IN TISSUES OF RODENTS (MAMMALIA: RODENTIA) |
title_sort |
species- and age-specific characteristics of the lactate dehydrogenase system in tissues of rodents (mammalia: rodentia) |
publisher |
Karelian Research Centre of the Russian Academy of Sciences |
publishDate |
2018 |
url |
https://doi.org/10.17076/them809 https://doaj.org/article/858d9f8925924c8282dfe11c75a40558 |
genre |
Tundra |
genre_facet |
Tundra |
op_source |
Transactions of the Karelian Research Centre of the Russian Academy of Sciences, Iss 4 (2018) |
op_relation |
http://journals.krc.karelia.ru/index.php/thematic/article/view/809 https://doaj.org/toc/1997-3217 https://doaj.org/toc/2312-4504 1997-3217 2312-4504 doi:10.17076/them809 https://doaj.org/article/858d9f8925924c8282dfe11c75a40558 |
op_doi |
https://doi.org/10.17076/them809 |
container_title |
Proceedings of the Karelian Research Centre of the Russian Academy of Sciences |
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4 |
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3 |
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