The potential of pregnant women as a sentinel population for malaria surveillance
Abstract Background With increasing spatial heterogeneity of malaria transmission and a shift of the disease burden towards older children and adults, pregnant women attending antenatal care (ANC) have been proposed as a pragmatic sentinel population for malaria surveillance. However, the representa...
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ftdoajarticles:oai:doaj.org/article:855db0fa1555491f9f29cf57723308ac 2023-05-15T15:10:59+02:00 The potential of pregnant women as a sentinel population for malaria surveillance Nina C. Brunner Frank Chacky Renata Mandike Ally Mohamed Manuela Runge Sumaiyya G. Thawer Amanda Ross Penelope Vounatsou Christian Lengeler Fabrizio Molteni Manuel W. Hetzel 2019-11-01T00:00:00Z https://doi.org/10.1186/s12936-019-2999-0 https://doaj.org/article/855db0fa1555491f9f29cf57723308ac EN eng BMC http://link.springer.com/article/10.1186/s12936-019-2999-0 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2999-0 1475-2875 https://doaj.org/article/855db0fa1555491f9f29cf57723308ac Malaria Journal, Vol 18, Iss 1, Pp 1-10 (2019) Malaria Surveillance Malaria elimination Pregnant women Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2019 ftdoajarticles https://doi.org/10.1186/s12936-019-2999-0 2022-12-31T01:56:23Z Abstract Background With increasing spatial heterogeneity of malaria transmission and a shift of the disease burden towards older children and adults, pregnant women attending antenatal care (ANC) have been proposed as a pragmatic sentinel population for malaria surveillance. However, the representativeness of routine ANC malaria test-positivity and its relationship with prevalence in other population subgroups are yet to be investigated. Methods Monthly ANC malaria test-positivity data from all Tanzanian health facilities for January 2014 to May 2016 was compared to prevalence data from the School Malaria Parasitaemia Survey 2015, the Malaria Indicator Survey (MIS) 2015/16, the Malaria Atlas Project 2015, and a Bayesian model fitted to MIS data. Linear regression was used to describe the difference between malaria test-positivity in pregnant women and respective comparison groups as a function of ANC test-positivity and potential covariates. Results The relationship between ANC test-positivity and survey prevalence in children follows spatially and biologically meaningful patterns. However, the uncertainty of the relationship was substantial, particularly in areas with high or perennial transmission. In comparison, modelled data estimated higher prevalence in children at low transmission intensities and lower prevalence at higher transmission intensities. Conclusions Pregnant women attending ANC are a pragmatic sentinel population to assess heterogeneity and trends in malaria prevalence in Tanzania. Yet, since ANC malaria test-positivity cannot be used to directly predict the prevalence in other population subgroups, complementary community-level measurements remain highly relevant. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 18 1 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
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English |
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Malaria Surveillance Malaria elimination Pregnant women Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria Surveillance Malaria elimination Pregnant women Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Nina C. Brunner Frank Chacky Renata Mandike Ally Mohamed Manuela Runge Sumaiyya G. Thawer Amanda Ross Penelope Vounatsou Christian Lengeler Fabrizio Molteni Manuel W. Hetzel The potential of pregnant women as a sentinel population for malaria surveillance |
topic_facet |
Malaria Surveillance Malaria elimination Pregnant women Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background With increasing spatial heterogeneity of malaria transmission and a shift of the disease burden towards older children and adults, pregnant women attending antenatal care (ANC) have been proposed as a pragmatic sentinel population for malaria surveillance. However, the representativeness of routine ANC malaria test-positivity and its relationship with prevalence in other population subgroups are yet to be investigated. Methods Monthly ANC malaria test-positivity data from all Tanzanian health facilities for January 2014 to May 2016 was compared to prevalence data from the School Malaria Parasitaemia Survey 2015, the Malaria Indicator Survey (MIS) 2015/16, the Malaria Atlas Project 2015, and a Bayesian model fitted to MIS data. Linear regression was used to describe the difference between malaria test-positivity in pregnant women and respective comparison groups as a function of ANC test-positivity and potential covariates. Results The relationship between ANC test-positivity and survey prevalence in children follows spatially and biologically meaningful patterns. However, the uncertainty of the relationship was substantial, particularly in areas with high or perennial transmission. In comparison, modelled data estimated higher prevalence in children at low transmission intensities and lower prevalence at higher transmission intensities. Conclusions Pregnant women attending ANC are a pragmatic sentinel population to assess heterogeneity and trends in malaria prevalence in Tanzania. Yet, since ANC malaria test-positivity cannot be used to directly predict the prevalence in other population subgroups, complementary community-level measurements remain highly relevant. |
format |
Article in Journal/Newspaper |
author |
Nina C. Brunner Frank Chacky Renata Mandike Ally Mohamed Manuela Runge Sumaiyya G. Thawer Amanda Ross Penelope Vounatsou Christian Lengeler Fabrizio Molteni Manuel W. Hetzel |
author_facet |
Nina C. Brunner Frank Chacky Renata Mandike Ally Mohamed Manuela Runge Sumaiyya G. Thawer Amanda Ross Penelope Vounatsou Christian Lengeler Fabrizio Molteni Manuel W. Hetzel |
author_sort |
Nina C. Brunner |
title |
The potential of pregnant women as a sentinel population for malaria surveillance |
title_short |
The potential of pregnant women as a sentinel population for malaria surveillance |
title_full |
The potential of pregnant women as a sentinel population for malaria surveillance |
title_fullStr |
The potential of pregnant women as a sentinel population for malaria surveillance |
title_full_unstemmed |
The potential of pregnant women as a sentinel population for malaria surveillance |
title_sort |
potential of pregnant women as a sentinel population for malaria surveillance |
publisher |
BMC |
publishDate |
2019 |
url |
https://doi.org/10.1186/s12936-019-2999-0 https://doaj.org/article/855db0fa1555491f9f29cf57723308ac |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 18, Iss 1, Pp 1-10 (2019) |
op_relation |
http://link.springer.com/article/10.1186/s12936-019-2999-0 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2999-0 1475-2875 https://doaj.org/article/855db0fa1555491f9f29cf57723308ac |
op_doi |
https://doi.org/10.1186/s12936-019-2999-0 |
container_title |
Malaria Journal |
container_volume |
18 |
container_issue |
1 |
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1766341903643574272 |