High risk for chikungunya virus to initiate an enzootic sylvatic cycle in the tropical Americas.
Background Chikungunya virus (CHIKV) has dispersed in the Americas since 2013, and its range of distribution has overlapped large forested areas. Herein, we assess vector competence of two sylvatic Neotropical mosquito species, Haemagogus leucocelaenus and Aedes terrens, to evaluate the risk of CHIK...
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ftdoajarticles:oai:doaj.org/article:8559f5383b364c36861fd1daae0d901c 2023-05-15T15:10:53+02:00 High risk for chikungunya virus to initiate an enzootic sylvatic cycle in the tropical Americas. Ricardo Lourenço-de-Oliveira Anna-Bella Failloux 2017-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005698 https://doaj.org/article/8559f5383b364c36861fd1daae0d901c EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0005698 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005698 https://doaj.org/article/8559f5383b364c36861fd1daae0d901c PLoS Neglected Tropical Diseases, Vol 11, Iss 6, p e0005698 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005698 2022-12-31T04:32:22Z Background Chikungunya virus (CHIKV) has dispersed in the Americas since 2013, and its range of distribution has overlapped large forested areas. Herein, we assess vector competence of two sylvatic Neotropical mosquito species, Haemagogus leucocelaenus and Aedes terrens, to evaluate the risk of CHIKV to initiate a sylvatic cycle in the continent. Methodology/principal findings Haemagogus leucocelaenus and Ae. terrens from the state of Rio de Janeiro, Brazil were orally challenged with the two CHIKV lineages circulating in the Americas. Fully engorged females were kept in incubators at 28±1°C and 70±10% humidity and examined at 3 and 7 days after virus exposure. Body (thorax plus abdomen), head and saliva samples were analyzed for respectively determining infection, dissemination and transmission. Both Hg. leucocelaenus and Ae. terrens exhibited high infection and dissemination rates with both CHIKV isolates at 7 dpi, demonstrating that they are susceptible to CHIKV, regardless of the lineage. Remarkably, Hg. leucocelaenus expectorated infectious viral particles as rapidly as 3 days after the infectious blood meal, displaying higher values of transmission rate and efficiency than Ae. terrens. Nevertheless, both species were competent to experimentally transmit both CHIKV genotypes, exhibiting vector competence similar to several American Aedes aegypti. Conclusions/significance These results point out the high risk for CHIKV to establish a sylvatic transmission cycle in the Americas, which could be a serious health issue as CHIKV would become another zoonotic infection difficult to control in the continent. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 6 e0005698 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ricardo Lourenço-de-Oliveira Anna-Bella Failloux High risk for chikungunya virus to initiate an enzootic sylvatic cycle in the tropical Americas. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Chikungunya virus (CHIKV) has dispersed in the Americas since 2013, and its range of distribution has overlapped large forested areas. Herein, we assess vector competence of two sylvatic Neotropical mosquito species, Haemagogus leucocelaenus and Aedes terrens, to evaluate the risk of CHIKV to initiate a sylvatic cycle in the continent. Methodology/principal findings Haemagogus leucocelaenus and Ae. terrens from the state of Rio de Janeiro, Brazil were orally challenged with the two CHIKV lineages circulating in the Americas. Fully engorged females were kept in incubators at 28±1°C and 70±10% humidity and examined at 3 and 7 days after virus exposure. Body (thorax plus abdomen), head and saliva samples were analyzed for respectively determining infection, dissemination and transmission. Both Hg. leucocelaenus and Ae. terrens exhibited high infection and dissemination rates with both CHIKV isolates at 7 dpi, demonstrating that they are susceptible to CHIKV, regardless of the lineage. Remarkably, Hg. leucocelaenus expectorated infectious viral particles as rapidly as 3 days after the infectious blood meal, displaying higher values of transmission rate and efficiency than Ae. terrens. Nevertheless, both species were competent to experimentally transmit both CHIKV genotypes, exhibiting vector competence similar to several American Aedes aegypti. Conclusions/significance These results point out the high risk for CHIKV to establish a sylvatic transmission cycle in the Americas, which could be a serious health issue as CHIKV would become another zoonotic infection difficult to control in the continent. |
format |
Article in Journal/Newspaper |
author |
Ricardo Lourenço-de-Oliveira Anna-Bella Failloux |
author_facet |
Ricardo Lourenço-de-Oliveira Anna-Bella Failloux |
author_sort |
Ricardo Lourenço-de-Oliveira |
title |
High risk for chikungunya virus to initiate an enzootic sylvatic cycle in the tropical Americas. |
title_short |
High risk for chikungunya virus to initiate an enzootic sylvatic cycle in the tropical Americas. |
title_full |
High risk for chikungunya virus to initiate an enzootic sylvatic cycle in the tropical Americas. |
title_fullStr |
High risk for chikungunya virus to initiate an enzootic sylvatic cycle in the tropical Americas. |
title_full_unstemmed |
High risk for chikungunya virus to initiate an enzootic sylvatic cycle in the tropical Americas. |
title_sort |
high risk for chikungunya virus to initiate an enzootic sylvatic cycle in the tropical americas. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005698 https://doaj.org/article/8559f5383b364c36861fd1daae0d901c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 6, p e0005698 (2017) |
op_relation |
https://doi.org/10.1371/journal.pntd.0005698 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005698 https://doaj.org/article/8559f5383b364c36861fd1daae0d901c |
op_doi |
https://doi.org/10.1371/journal.pntd.0005698 |
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PLOS Neglected Tropical Diseases |
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11 |
container_issue |
6 |
container_start_page |
e0005698 |
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