How correlations between treatment access and surveillance inclusion impact neglected tropical disease monitoring and evaluation-A simulated study.
Neglected tropical diseases (NTDs) largely impact marginalised communities living in tropical and subtropical regions. Mass drug administration is the leading intervention method for five NTDs; however, it is known that there is lack of access to treatment for some populations and demographic groups...
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ftdoajarticles:oai:doaj.org/article:8514fb37fb624966b0d73e8ba6939882 2023-11-05T03:39:51+01:00 How correlations between treatment access and surveillance inclusion impact neglected tropical disease monitoring and evaluation-A simulated study. Jessica Clark Emma L Davis Joaquin M Prada Katherine Gass Alison Krentel T Déirdre Hollingsworth 2023-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0011582 https://doaj.org/article/8514fb37fb624966b0d73e8ba6939882 EN eng Public Library of Science (PLoS) https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011582&type=printable https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011582 https://doaj.org/article/8514fb37fb624966b0d73e8ba6939882 PLoS Neglected Tropical Diseases, Vol 17, Iss 9, p e0011582 (2023) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2023 ftdoajarticles https://doi.org/10.1371/journal.pntd.0011582 2023-10-08T00:37:57Z Neglected tropical diseases (NTDs) largely impact marginalised communities living in tropical and subtropical regions. Mass drug administration is the leading intervention method for five NTDs; however, it is known that there is lack of access to treatment for some populations and demographic groups. It is also likely that those individuals without access to treatment are excluded from surveillance. It is important to consider the impacts of this on the overall success, and monitoring and evaluation (M&E) of intervention programmes. We use a detailed individual-based model of the infection dynamics of lymphatic filariasis to investigate the impact of excluded, untreated, and therefore unobserved groups on the true versus observed infection dynamics and subsequent intervention success. We simulate surveillance in four groups-the whole population eligible to receive treatment, the whole eligible population with access to treatment, the TAS focus of six- and seven-year-olds, and finally in >20-year-olds. We show that the surveillance group under observation has a significant impact on perceived dynamics. Exclusion to treatment and surveillance negatively impacts the probability of reaching public health goals, though in populations that do reach these goals there are no signals to indicate excluded groups. Increasingly restricted surveillance groups over-estimate the efficacy of MDA. The presence of non-treated groups cannot be inferred when surveillance is only occurring in the group receiving treatment. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles PLOS Neglected Tropical Diseases 17 9 e0011582 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Jessica Clark Emma L Davis Joaquin M Prada Katherine Gass Alison Krentel T Déirdre Hollingsworth How correlations between treatment access and surveillance inclusion impact neglected tropical disease monitoring and evaluation-A simulated study. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Neglected tropical diseases (NTDs) largely impact marginalised communities living in tropical and subtropical regions. Mass drug administration is the leading intervention method for five NTDs; however, it is known that there is lack of access to treatment for some populations and demographic groups. It is also likely that those individuals without access to treatment are excluded from surveillance. It is important to consider the impacts of this on the overall success, and monitoring and evaluation (M&E) of intervention programmes. We use a detailed individual-based model of the infection dynamics of lymphatic filariasis to investigate the impact of excluded, untreated, and therefore unobserved groups on the true versus observed infection dynamics and subsequent intervention success. We simulate surveillance in four groups-the whole population eligible to receive treatment, the whole eligible population with access to treatment, the TAS focus of six- and seven-year-olds, and finally in >20-year-olds. We show that the surveillance group under observation has a significant impact on perceived dynamics. Exclusion to treatment and surveillance negatively impacts the probability of reaching public health goals, though in populations that do reach these goals there are no signals to indicate excluded groups. Increasingly restricted surveillance groups over-estimate the efficacy of MDA. The presence of non-treated groups cannot be inferred when surveillance is only occurring in the group receiving treatment. |
format |
Article in Journal/Newspaper |
author |
Jessica Clark Emma L Davis Joaquin M Prada Katherine Gass Alison Krentel T Déirdre Hollingsworth |
author_facet |
Jessica Clark Emma L Davis Joaquin M Prada Katherine Gass Alison Krentel T Déirdre Hollingsworth |
author_sort |
Jessica Clark |
title |
How correlations between treatment access and surveillance inclusion impact neglected tropical disease monitoring and evaluation-A simulated study. |
title_short |
How correlations between treatment access and surveillance inclusion impact neglected tropical disease monitoring and evaluation-A simulated study. |
title_full |
How correlations between treatment access and surveillance inclusion impact neglected tropical disease monitoring and evaluation-A simulated study. |
title_fullStr |
How correlations between treatment access and surveillance inclusion impact neglected tropical disease monitoring and evaluation-A simulated study. |
title_full_unstemmed |
How correlations between treatment access and surveillance inclusion impact neglected tropical disease monitoring and evaluation-A simulated study. |
title_sort |
how correlations between treatment access and surveillance inclusion impact neglected tropical disease monitoring and evaluation-a simulated study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2023 |
url |
https://doi.org/10.1371/journal.pntd.0011582 https://doaj.org/article/8514fb37fb624966b0d73e8ba6939882 |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 17, Iss 9, p e0011582 (2023) |
op_relation |
https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011582&type=printable https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011582 https://doaj.org/article/8514fb37fb624966b0d73e8ba6939882 |
op_doi |
https://doi.org/10.1371/journal.pntd.0011582 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
17 |
container_issue |
9 |
container_start_page |
e0011582 |
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