A Rare Case of Ulceronodular Cutaneous Metastases from Nasopharyngeal Carcinoma
Nasopharyngeal cancer is a rare cancer in most part of the world, but commonly seen in natives of southern China, Southeast Asia, the Arctic, and the Middle East/North Africa. It is sensitive to radiotherapy and chemotherapy and is usually treated by chemoradiation. It is highly predisposed to nodal...
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ftdoajarticles:oai:doaj.org/article:851414709b0b4b318054867333b35faf 2023-05-15T15:06:39+02:00 A Rare Case of Ulceronodular Cutaneous Metastases from Nasopharyngeal Carcinoma Richa Chauhan Naveen Kuna Vinita Trivedi Rita Rani Usha Singh Vasudha Singh 2017-12-01T00:00:00Z https://doi.org/10.7860/JCDR/2017/32832.11016 https://doaj.org/article/851414709b0b4b318054867333b35faf EN eng JCDR Research and Publications Private Limited https://jcdr.net/articles/PDF/11016/32832-F(SHU)_PF1(AD_GG)_PFA(MJ_AP).pdf https://doaj.org/toc/2249-782X https://doaj.org/toc/0973-709X doi:10.7860/JCDR/2017/32832.11016 2249-782X 0973-709X https://doaj.org/article/851414709b0b4b318054867333b35faf Journal of Clinical and Diagnostic Research, Vol 11, Iss 12, Pp XD06-XD08 (2017) chemoresistance nasopharyngeal cancer radiosensitivity Medicine R article 2017 ftdoajarticles https://doi.org/10.7860/JCDR/2017/32832.11016 2022-12-31T12:22:20Z Nasopharyngeal cancer is a rare cancer in most part of the world, but commonly seen in natives of southern China, Southeast Asia, the Arctic, and the Middle East/North Africa. It is sensitive to radiotherapy and chemotherapy and is usually treated by chemoradiation. It is highly predisposed to nodal and distant metastasis. Still, cutaneous metastasis is rarely seen. Here in this report, we present the case of nasopharyngeal carcinoma with an ulceronodular type of cutaneous metastasis, presenting six years after the initial diagnosis without any visceral metastases. Another feature noted in our patient was the sensitivity to low dose radiotherapy both for bulky primary disease which was progressive on 5Fluorouracil (5FU) and cisplatin based chemotherapy, and subsequent metastases. Theoretically, skin metastases can occur through spread via dermal lymphatics or when the pulmonary filtration is bypassed via the vertebral venous system and Batson’s plexus allowing skin implantation. Further, resistance to chemotherapy and high sensitivity to radiation suggests heterogeneity among nasopharyngeal cancers with intrinsic molecular subtype. The good response of metastatic disease to short course radiation suggests that patients with cutaneous and nodal metastases without visceral metastases could be aggressively treated and the patient can have a good quality of life. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
chemoresistance nasopharyngeal cancer radiosensitivity Medicine R |
spellingShingle |
chemoresistance nasopharyngeal cancer radiosensitivity Medicine R Richa Chauhan Naveen Kuna Vinita Trivedi Rita Rani Usha Singh Vasudha Singh A Rare Case of Ulceronodular Cutaneous Metastases from Nasopharyngeal Carcinoma |
topic_facet |
chemoresistance nasopharyngeal cancer radiosensitivity Medicine R |
description |
Nasopharyngeal cancer is a rare cancer in most part of the world, but commonly seen in natives of southern China, Southeast Asia, the Arctic, and the Middle East/North Africa. It is sensitive to radiotherapy and chemotherapy and is usually treated by chemoradiation. It is highly predisposed to nodal and distant metastasis. Still, cutaneous metastasis is rarely seen. Here in this report, we present the case of nasopharyngeal carcinoma with an ulceronodular type of cutaneous metastasis, presenting six years after the initial diagnosis without any visceral metastases. Another feature noted in our patient was the sensitivity to low dose radiotherapy both for bulky primary disease which was progressive on 5Fluorouracil (5FU) and cisplatin based chemotherapy, and subsequent metastases. Theoretically, skin metastases can occur through spread via dermal lymphatics or when the pulmonary filtration is bypassed via the vertebral venous system and Batson’s plexus allowing skin implantation. Further, resistance to chemotherapy and high sensitivity to radiation suggests heterogeneity among nasopharyngeal cancers with intrinsic molecular subtype. The good response of metastatic disease to short course radiation suggests that patients with cutaneous and nodal metastases without visceral metastases could be aggressively treated and the patient can have a good quality of life. |
format |
Article in Journal/Newspaper |
author |
Richa Chauhan Naveen Kuna Vinita Trivedi Rita Rani Usha Singh Vasudha Singh |
author_facet |
Richa Chauhan Naveen Kuna Vinita Trivedi Rita Rani Usha Singh Vasudha Singh |
author_sort |
Richa Chauhan |
title |
A Rare Case of Ulceronodular Cutaneous Metastases from Nasopharyngeal Carcinoma |
title_short |
A Rare Case of Ulceronodular Cutaneous Metastases from Nasopharyngeal Carcinoma |
title_full |
A Rare Case of Ulceronodular Cutaneous Metastases from Nasopharyngeal Carcinoma |
title_fullStr |
A Rare Case of Ulceronodular Cutaneous Metastases from Nasopharyngeal Carcinoma |
title_full_unstemmed |
A Rare Case of Ulceronodular Cutaneous Metastases from Nasopharyngeal Carcinoma |
title_sort |
rare case of ulceronodular cutaneous metastases from nasopharyngeal carcinoma |
publisher |
JCDR Research and Publications Private Limited |
publishDate |
2017 |
url |
https://doi.org/10.7860/JCDR/2017/32832.11016 https://doaj.org/article/851414709b0b4b318054867333b35faf |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Clinical and Diagnostic Research, Vol 11, Iss 12, Pp XD06-XD08 (2017) |
op_relation |
https://jcdr.net/articles/PDF/11016/32832-F(SHU)_PF1(AD_GG)_PFA(MJ_AP).pdf https://doaj.org/toc/2249-782X https://doaj.org/toc/0973-709X doi:10.7860/JCDR/2017/32832.11016 2249-782X 0973-709X https://doaj.org/article/851414709b0b4b318054867333b35faf |
op_doi |
https://doi.org/10.7860/JCDR/2017/32832.11016 |
container_title |
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH |
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