Deleterious effect of Usutu virus on human neural cells.
In the last decade, the number of emerging Flaviviruses described worldwide has increased considerably. Among them Zika virus (ZIKV) and Usutu virus (USUV) are African mosquito-borne viruses that recently emerged. Recently, ZIKV has been intensely studied due to major outbreaks associated with neona...
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ftdoajarticles:oai:doaj.org/article:8507367cfdf9455fa3fbaf624bd0d5da 2023-05-15T15:07:55+02:00 Deleterious effect of Usutu virus on human neural cells. Sara Salinas Orianne Constant Caroline Desmetz Jonathan Barthelemy Jean-Marc Lemaitre Ollivier Milhavet Nicolas Nagot Vincent Foulongne Florence E Perrin Juan-Carlos Saiz Sylvie Lecollinet Philippe Van de Perre Yannick Simonin 2017-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005913 https://doaj.org/article/8507367cfdf9455fa3fbaf624bd0d5da EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5600396?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005913 https://doaj.org/article/8507367cfdf9455fa3fbaf624bd0d5da PLoS Neglected Tropical Diseases, Vol 11, Iss 9, p e0005913 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005913 2022-12-30T21:57:31Z In the last decade, the number of emerging Flaviviruses described worldwide has increased considerably. Among them Zika virus (ZIKV) and Usutu virus (USUV) are African mosquito-borne viruses that recently emerged. Recently, ZIKV has been intensely studied due to major outbreaks associated with neonatal death and birth defects, as well as neurological symptoms. USUV pathogenesis remains largely unexplored, despite significant human and veterinary associated disorders. Circulation of USUV in Africa was documented more than 50 years ago, and it emerged in Europe two decades ago, causing massive bird mortality. More recently, USUV has been described to be associated with neurological disorders in humans such as encephalitis and meningoencephalitis, highlighting USUV as a potential health threat. The aim of this study was to evaluate the ability of USUV to infect neuronal cells. Our results indicate that USUV efficiently infects neurons, astrocytes, microglia and IPSc-derived human neuronal stem cells. When compared to ZIKV, USUV led to a higher infection rate, viral production, as well as stronger cell death and anti-viral response. Our results highlight the need to better characterize the physiopathology related to USUV infection in order to anticipate the potential threat of USUV emergence. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 9 e0005913 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Sara Salinas Orianne Constant Caroline Desmetz Jonathan Barthelemy Jean-Marc Lemaitre Ollivier Milhavet Nicolas Nagot Vincent Foulongne Florence E Perrin Juan-Carlos Saiz Sylvie Lecollinet Philippe Van de Perre Yannick Simonin Deleterious effect of Usutu virus on human neural cells. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
In the last decade, the number of emerging Flaviviruses described worldwide has increased considerably. Among them Zika virus (ZIKV) and Usutu virus (USUV) are African mosquito-borne viruses that recently emerged. Recently, ZIKV has been intensely studied due to major outbreaks associated with neonatal death and birth defects, as well as neurological symptoms. USUV pathogenesis remains largely unexplored, despite significant human and veterinary associated disorders. Circulation of USUV in Africa was documented more than 50 years ago, and it emerged in Europe two decades ago, causing massive bird mortality. More recently, USUV has been described to be associated with neurological disorders in humans such as encephalitis and meningoencephalitis, highlighting USUV as a potential health threat. The aim of this study was to evaluate the ability of USUV to infect neuronal cells. Our results indicate that USUV efficiently infects neurons, astrocytes, microglia and IPSc-derived human neuronal stem cells. When compared to ZIKV, USUV led to a higher infection rate, viral production, as well as stronger cell death and anti-viral response. Our results highlight the need to better characterize the physiopathology related to USUV infection in order to anticipate the potential threat of USUV emergence. |
format |
Article in Journal/Newspaper |
author |
Sara Salinas Orianne Constant Caroline Desmetz Jonathan Barthelemy Jean-Marc Lemaitre Ollivier Milhavet Nicolas Nagot Vincent Foulongne Florence E Perrin Juan-Carlos Saiz Sylvie Lecollinet Philippe Van de Perre Yannick Simonin |
author_facet |
Sara Salinas Orianne Constant Caroline Desmetz Jonathan Barthelemy Jean-Marc Lemaitre Ollivier Milhavet Nicolas Nagot Vincent Foulongne Florence E Perrin Juan-Carlos Saiz Sylvie Lecollinet Philippe Van de Perre Yannick Simonin |
author_sort |
Sara Salinas |
title |
Deleterious effect of Usutu virus on human neural cells. |
title_short |
Deleterious effect of Usutu virus on human neural cells. |
title_full |
Deleterious effect of Usutu virus on human neural cells. |
title_fullStr |
Deleterious effect of Usutu virus on human neural cells. |
title_full_unstemmed |
Deleterious effect of Usutu virus on human neural cells. |
title_sort |
deleterious effect of usutu virus on human neural cells. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005913 https://doaj.org/article/8507367cfdf9455fa3fbaf624bd0d5da |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 9, p e0005913 (2017) |
op_relation |
http://europepmc.org/articles/PMC5600396?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005913 https://doaj.org/article/8507367cfdf9455fa3fbaf624bd0d5da |
op_doi |
https://doi.org/10.1371/journal.pntd.0005913 |
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PLOS Neglected Tropical Diseases |
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11 |
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e0005913 |
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