A comparative study about EPA-PL and EPA-EE on ameliorating behavioral deficits in MPTP-induced mice with Parkinson’s disease by suppressing oxidative stress and apoptosis
Eicosapentaenoic acid (EPA) enriched phospholipids (EPA-PL) are widely distributed in marine products. It has been reported that the protective effects of the mixture of EPA and docosahexaenoic acid (DHA) on Parkinson’s disease (PD), however, it is hard to confirm the improvement of EPA alone on PD....
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ftdoajarticles:oai:doaj.org/article:84ebf7a9a94b4a08b66ba0919717845e 2023-05-15T15:59:38+02:00 A comparative study about EPA-PL and EPA-EE on ameliorating behavioral deficits in MPTP-induced mice with Parkinson’s disease by suppressing oxidative stress and apoptosis Cheng-Cheng Wang Dan Wang Tian-Tian Zhang Teruyoshi Yanagita Chang-Hu Xue Yao-Guang Chang Yu-Ming Wang 2018-11-01T00:00:00Z https://doi.org/10.1016/j.jff.2018.09.027 https://doaj.org/article/84ebf7a9a94b4a08b66ba0919717845e EN eng Elsevier http://www.sciencedirect.com/science/article/pii/S1756464618305036 https://doaj.org/toc/1756-4646 1756-4646 doi:10.1016/j.jff.2018.09.027 https://doaj.org/article/84ebf7a9a94b4a08b66ba0919717845e Journal of Functional Foods, Vol 50, Iss , Pp 8-17 (2018) EPA-PL EPA-EE Parkinson’s disease Apoptosis Oxidative stress Nutrition. Foods and food supply TX341-641 article 2018 ftdoajarticles https://doi.org/10.1016/j.jff.2018.09.027 2022-12-31T07:47:39Z Eicosapentaenoic acid (EPA) enriched phospholipids (EPA-PL) are widely distributed in marine products. It has been reported that the protective effects of the mixture of EPA and docosahexaenoic acid (DHA) on Parkinson’s disease (PD), however, it is hard to confirm the improvement of EPA alone on PD. In the present study, EPA-PL was extracted from the sea cucumber (Cucumaria frondosa) to compare the effects of EPA-PL and commercial EPA in the form of ethyl ester (EPA-EE) on PD mice induced by 1-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine (MPTP). Results showed that dietary EPA-PL instead of EPA-EE notably improved MPTP-induced behavioral deficiency. Further research showed that EPA-PL suppressed MPTP-induced oxidative stress and apoptosis, thereby alleviating the loss of dopaminergic neurons via mitochondria – mediated pathway and mitogen-activated protein kinase pathway. These findings firstly confirmed that EPA-PL could improve MPTP-induced symptoms and pathology of PD, providing a reference for the prevention and treatment of neurodegenerative diseases. Article in Journal/Newspaper Cucumaria frondosa Directory of Open Access Journals: DOAJ Articles Journal of Functional Foods 50 8 17 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
EPA-PL EPA-EE Parkinson’s disease Apoptosis Oxidative stress Nutrition. Foods and food supply TX341-641 |
spellingShingle |
EPA-PL EPA-EE Parkinson’s disease Apoptosis Oxidative stress Nutrition. Foods and food supply TX341-641 Cheng-Cheng Wang Dan Wang Tian-Tian Zhang Teruyoshi Yanagita Chang-Hu Xue Yao-Guang Chang Yu-Ming Wang A comparative study about EPA-PL and EPA-EE on ameliorating behavioral deficits in MPTP-induced mice with Parkinson’s disease by suppressing oxidative stress and apoptosis |
topic_facet |
EPA-PL EPA-EE Parkinson’s disease Apoptosis Oxidative stress Nutrition. Foods and food supply TX341-641 |
description |
Eicosapentaenoic acid (EPA) enriched phospholipids (EPA-PL) are widely distributed in marine products. It has been reported that the protective effects of the mixture of EPA and docosahexaenoic acid (DHA) on Parkinson’s disease (PD), however, it is hard to confirm the improvement of EPA alone on PD. In the present study, EPA-PL was extracted from the sea cucumber (Cucumaria frondosa) to compare the effects of EPA-PL and commercial EPA in the form of ethyl ester (EPA-EE) on PD mice induced by 1-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine (MPTP). Results showed that dietary EPA-PL instead of EPA-EE notably improved MPTP-induced behavioral deficiency. Further research showed that EPA-PL suppressed MPTP-induced oxidative stress and apoptosis, thereby alleviating the loss of dopaminergic neurons via mitochondria – mediated pathway and mitogen-activated protein kinase pathway. These findings firstly confirmed that EPA-PL could improve MPTP-induced symptoms and pathology of PD, providing a reference for the prevention and treatment of neurodegenerative diseases. |
format |
Article in Journal/Newspaper |
author |
Cheng-Cheng Wang Dan Wang Tian-Tian Zhang Teruyoshi Yanagita Chang-Hu Xue Yao-Guang Chang Yu-Ming Wang |
author_facet |
Cheng-Cheng Wang Dan Wang Tian-Tian Zhang Teruyoshi Yanagita Chang-Hu Xue Yao-Guang Chang Yu-Ming Wang |
author_sort |
Cheng-Cheng Wang |
title |
A comparative study about EPA-PL and EPA-EE on ameliorating behavioral deficits in MPTP-induced mice with Parkinson’s disease by suppressing oxidative stress and apoptosis |
title_short |
A comparative study about EPA-PL and EPA-EE on ameliorating behavioral deficits in MPTP-induced mice with Parkinson’s disease by suppressing oxidative stress and apoptosis |
title_full |
A comparative study about EPA-PL and EPA-EE on ameliorating behavioral deficits in MPTP-induced mice with Parkinson’s disease by suppressing oxidative stress and apoptosis |
title_fullStr |
A comparative study about EPA-PL and EPA-EE on ameliorating behavioral deficits in MPTP-induced mice with Parkinson’s disease by suppressing oxidative stress and apoptosis |
title_full_unstemmed |
A comparative study about EPA-PL and EPA-EE on ameliorating behavioral deficits in MPTP-induced mice with Parkinson’s disease by suppressing oxidative stress and apoptosis |
title_sort |
comparative study about epa-pl and epa-ee on ameliorating behavioral deficits in mptp-induced mice with parkinson’s disease by suppressing oxidative stress and apoptosis |
publisher |
Elsevier |
publishDate |
2018 |
url |
https://doi.org/10.1016/j.jff.2018.09.027 https://doaj.org/article/84ebf7a9a94b4a08b66ba0919717845e |
genre |
Cucumaria frondosa |
genre_facet |
Cucumaria frondosa |
op_source |
Journal of Functional Foods, Vol 50, Iss , Pp 8-17 (2018) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S1756464618305036 https://doaj.org/toc/1756-4646 1756-4646 doi:10.1016/j.jff.2018.09.027 https://doaj.org/article/84ebf7a9a94b4a08b66ba0919717845e |
op_doi |
https://doi.org/10.1016/j.jff.2018.09.027 |
container_title |
Journal of Functional Foods |
container_volume |
50 |
container_start_page |
8 |
op_container_end_page |
17 |
_version_ |
1766395569915297792 |