mHAT app for automated malaria rapid test result analysis and aggregation: a pilot study
Abstract Background There are a variety of approaches being used for malaria surveillance. While active and reactive case detection have been successful in localized areas of low transmission, concerns over scalability and sustainability keep the approaches from being widely accepted. Mobile health...
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ftdoajarticles:oai:doaj.org/article:84d06732188b4da0bac52e67b0de53d1 2023-05-15T15:14:51+02:00 mHAT app for automated malaria rapid test result analysis and aggregation: a pilot study Carson Moore Thomas Scherr Japhet Matoba Caison Sing’anga Mukuma Lubinda Phil Thuma David Wright 2021-05-01T00:00:00Z https://doi.org/10.1186/s12936-021-03772-5 https://doaj.org/article/84d06732188b4da0bac52e67b0de53d1 EN eng BMC https://doi.org/10.1186/s12936-021-03772-5 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-021-03772-5 1475-2875 https://doaj.org/article/84d06732188b4da0bac52e67b0de53d1 Malaria Journal, Vol 20, Iss 1, Pp 1-11 (2021) Mobile health Malaria Rapid diagnostic test Application development Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2021 ftdoajarticles https://doi.org/10.1186/s12936-021-03772-5 2022-12-31T06:38:59Z Abstract Background There are a variety of approaches being used for malaria surveillance. While active and reactive case detection have been successful in localized areas of low transmission, concerns over scalability and sustainability keep the approaches from being widely accepted. Mobile health interventions are poised to address these shortcomings by automating and standardizing portions of the surveillance process. In this study, common challenges associated with current data aggregation methods have been quantified, and a web-based mobile phone application is presented to reduce the burden of reporting rapid diagnostic test (RDT) results in low-resource settings. Methods De-identified completed RDTs were collected at 14 rural health clinics as part of a malaria epidemiology study at Macha Research Trust, Macha, Zambia. Tests were imaged using the mHAT web application. Signal intensity was measured and a binary result was provided. App performance was validated by: (1) comparative limits of detection, investigated against currently used laboratory lateral flow assay readers; and, (2) receiver operating characteristic analysis comparing the application against visual inspection of RDTs by an expert. Secondary investigations included analysis of time-to-aggregation and data consistency within the existing surveillance structures established by Macha Research Trust. Results When compared to visual analysis, the mHAT app performed with 91.9% sensitivity (CI 78.7, 97.2) and specificity was 91.4% (CI 77.6, 97.0) regardless of device operating system. Additionally, an analysis of surveillance data from January 2017 through mid-February 2019 showed that while the majority of the data packets from satellite clinics contained correct data, 36% of data points required correction by verification teams. Between November 2018 and mid-February 2019, it was also found that 44.8% of data was received after the expected submission date, although most (65.1%) reports were received within 2 days. Conclusions Overall, the mHAT ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Macha ENVELOPE(127.166,127.166,73.003,73.003) Malaria Journal 20 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Mobile health Malaria Rapid diagnostic test Application development Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Mobile health Malaria Rapid diagnostic test Application development Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Carson Moore Thomas Scherr Japhet Matoba Caison Sing’anga Mukuma Lubinda Phil Thuma David Wright mHAT app for automated malaria rapid test result analysis and aggregation: a pilot study |
topic_facet |
Mobile health Malaria Rapid diagnostic test Application development Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background There are a variety of approaches being used for malaria surveillance. While active and reactive case detection have been successful in localized areas of low transmission, concerns over scalability and sustainability keep the approaches from being widely accepted. Mobile health interventions are poised to address these shortcomings by automating and standardizing portions of the surveillance process. In this study, common challenges associated with current data aggregation methods have been quantified, and a web-based mobile phone application is presented to reduce the burden of reporting rapid diagnostic test (RDT) results in low-resource settings. Methods De-identified completed RDTs were collected at 14 rural health clinics as part of a malaria epidemiology study at Macha Research Trust, Macha, Zambia. Tests were imaged using the mHAT web application. Signal intensity was measured and a binary result was provided. App performance was validated by: (1) comparative limits of detection, investigated against currently used laboratory lateral flow assay readers; and, (2) receiver operating characteristic analysis comparing the application against visual inspection of RDTs by an expert. Secondary investigations included analysis of time-to-aggregation and data consistency within the existing surveillance structures established by Macha Research Trust. Results When compared to visual analysis, the mHAT app performed with 91.9% sensitivity (CI 78.7, 97.2) and specificity was 91.4% (CI 77.6, 97.0) regardless of device operating system. Additionally, an analysis of surveillance data from January 2017 through mid-February 2019 showed that while the majority of the data packets from satellite clinics contained correct data, 36% of data points required correction by verification teams. Between November 2018 and mid-February 2019, it was also found that 44.8% of data was received after the expected submission date, although most (65.1%) reports were received within 2 days. Conclusions Overall, the mHAT ... |
format |
Article in Journal/Newspaper |
author |
Carson Moore Thomas Scherr Japhet Matoba Caison Sing’anga Mukuma Lubinda Phil Thuma David Wright |
author_facet |
Carson Moore Thomas Scherr Japhet Matoba Caison Sing’anga Mukuma Lubinda Phil Thuma David Wright |
author_sort |
Carson Moore |
title |
mHAT app for automated malaria rapid test result analysis and aggregation: a pilot study |
title_short |
mHAT app for automated malaria rapid test result analysis and aggregation: a pilot study |
title_full |
mHAT app for automated malaria rapid test result analysis and aggregation: a pilot study |
title_fullStr |
mHAT app for automated malaria rapid test result analysis and aggregation: a pilot study |
title_full_unstemmed |
mHAT app for automated malaria rapid test result analysis and aggregation: a pilot study |
title_sort |
mhat app for automated malaria rapid test result analysis and aggregation: a pilot study |
publisher |
BMC |
publishDate |
2021 |
url |
https://doi.org/10.1186/s12936-021-03772-5 https://doaj.org/article/84d06732188b4da0bac52e67b0de53d1 |
long_lat |
ENVELOPE(127.166,127.166,73.003,73.003) |
geographic |
Arctic Macha |
geographic_facet |
Arctic Macha |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 20, Iss 1, Pp 1-11 (2021) |
op_relation |
https://doi.org/10.1186/s12936-021-03772-5 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-021-03772-5 1475-2875 https://doaj.org/article/84d06732188b4da0bac52e67b0de53d1 |
op_doi |
https://doi.org/10.1186/s12936-021-03772-5 |
container_title |
Malaria Journal |
container_volume |
20 |
container_issue |
1 |
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1766345255763836928 |