Persistence of dengue serotype 2 viral RNA in blood cells of a returned traveler with dengue fever
Dengue virus (DENV) is one of the most significant vector-borne pathogens worldwide. In this report, we describe clinical features and laboratory detection of dengue in a 45-year-old traveler to Nicaragua on return home to the United States in 2019. Clinical presentation was mild, with rash, headach...
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ftdoajarticles:oai:doaj.org/article:84ca5d74b529443cbe86bc44e5120ebc 2024-09-09T19:26:00+00:00 Persistence of dengue serotype 2 viral RNA in blood cells of a returned traveler with dengue fever Rebecca S.B. Fischer Samuel Vilchez Shannon E. Ronca Rebecca Kairis Allison Lino Adrianna Maliga Sarah M. Gunter Kristy O. Murray 2024-05-01T00:00:00Z https://doi.org/10.1016/j.tmaid.2024.102699 https://doaj.org/article/84ca5d74b529443cbe86bc44e5120ebc EN eng Elsevier http://www.sciencedirect.com/science/article/pii/S1477893924000139 https://doaj.org/toc/1873-0442 1873-0442 doi:10.1016/j.tmaid.2024.102699 https://doaj.org/article/84ca5d74b529443cbe86bc44e5120ebc Travel Medicine and Infectious Disease, Vol 59, Iss , Pp 102699- (2024) Dengue virus (DENV) Serotype 2 Arbovirus infection Viral RNA persistence Dengue fever Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2024 ftdoajarticles https://doi.org/10.1016/j.tmaid.2024.102699 2024-08-05T17:49:25Z Dengue virus (DENV) is one of the most significant vector-borne pathogens worldwide. In this report, we describe clinical features and laboratory detection of dengue in a 45-year-old traveler to Nicaragua on return home to the United States in 2019. Clinical presentation was mild, with rash, headache, and fatigue, with only low-grade transient fever. Infection dynamics were documented by serology and PCR of serially collected body fluids. DENV serotype 2 was detected in whole blood 1 day after symptoms emerged, with viral RNA isolated to the red cell fraction, and remained detectable through day 89. DENV-2 RNA was detected in serum only on day 4, and IgM was undetectable on day 4 but evident by day 13. Viral RNA was also detected in urine. This report of DENV-2 RNA persistence in blood cells but only transient appearance in serum, supports the potential diagnostic value of whole blood over serum for PCR and opportunity of an expanded testing window. Informed testing approaches can improve diagnostic accuracy and inform strategies that preserve individual and public health. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Travel Medicine and Infectious Disease 59 102699 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Dengue virus (DENV) Serotype 2 Arbovirus infection Viral RNA persistence Dengue fever Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Dengue virus (DENV) Serotype 2 Arbovirus infection Viral RNA persistence Dengue fever Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Rebecca S.B. Fischer Samuel Vilchez Shannon E. Ronca Rebecca Kairis Allison Lino Adrianna Maliga Sarah M. Gunter Kristy O. Murray Persistence of dengue serotype 2 viral RNA in blood cells of a returned traveler with dengue fever |
topic_facet |
Dengue virus (DENV) Serotype 2 Arbovirus infection Viral RNA persistence Dengue fever Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Dengue virus (DENV) is one of the most significant vector-borne pathogens worldwide. In this report, we describe clinical features and laboratory detection of dengue in a 45-year-old traveler to Nicaragua on return home to the United States in 2019. Clinical presentation was mild, with rash, headache, and fatigue, with only low-grade transient fever. Infection dynamics were documented by serology and PCR of serially collected body fluids. DENV serotype 2 was detected in whole blood 1 day after symptoms emerged, with viral RNA isolated to the red cell fraction, and remained detectable through day 89. DENV-2 RNA was detected in serum only on day 4, and IgM was undetectable on day 4 but evident by day 13. Viral RNA was also detected in urine. This report of DENV-2 RNA persistence in blood cells but only transient appearance in serum, supports the potential diagnostic value of whole blood over serum for PCR and opportunity of an expanded testing window. Informed testing approaches can improve diagnostic accuracy and inform strategies that preserve individual and public health. |
format |
Article in Journal/Newspaper |
author |
Rebecca S.B. Fischer Samuel Vilchez Shannon E. Ronca Rebecca Kairis Allison Lino Adrianna Maliga Sarah M. Gunter Kristy O. Murray |
author_facet |
Rebecca S.B. Fischer Samuel Vilchez Shannon E. Ronca Rebecca Kairis Allison Lino Adrianna Maliga Sarah M. Gunter Kristy O. Murray |
author_sort |
Rebecca S.B. Fischer |
title |
Persistence of dengue serotype 2 viral RNA in blood cells of a returned traveler with dengue fever |
title_short |
Persistence of dengue serotype 2 viral RNA in blood cells of a returned traveler with dengue fever |
title_full |
Persistence of dengue serotype 2 viral RNA in blood cells of a returned traveler with dengue fever |
title_fullStr |
Persistence of dengue serotype 2 viral RNA in blood cells of a returned traveler with dengue fever |
title_full_unstemmed |
Persistence of dengue serotype 2 viral RNA in blood cells of a returned traveler with dengue fever |
title_sort |
persistence of dengue serotype 2 viral rna in blood cells of a returned traveler with dengue fever |
publisher |
Elsevier |
publishDate |
2024 |
url |
https://doi.org/10.1016/j.tmaid.2024.102699 https://doaj.org/article/84ca5d74b529443cbe86bc44e5120ebc |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Travel Medicine and Infectious Disease, Vol 59, Iss , Pp 102699- (2024) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S1477893924000139 https://doaj.org/toc/1873-0442 1873-0442 doi:10.1016/j.tmaid.2024.102699 https://doaj.org/article/84ca5d74b529443cbe86bc44e5120ebc |
op_doi |
https://doi.org/10.1016/j.tmaid.2024.102699 |
container_title |
Travel Medicine and Infectious Disease |
container_volume |
59 |
container_start_page |
102699 |
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1809895706640515072 |