Syringic acid improves oxidative stress and mitochondrial biogenesis in the liver of streptozotocin-induced diabetic rats
Objective: To determine the effects of syringic acid on hepatic damage in diabetic rats. Methods: Diabetes was induced by streptozotocin. Diabetic rats were given syringic acid at doses of 25, 50 and 100 mg/kg by oral gavage for 6 weeks. Syringic acid effects on the liver were evaluated by examinati...
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Wolters Kluwer Medknow Publications
2020
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ftdoajarticles:oai:doaj.org/article:84c3d8c0aa8f4f70952c003a32116e18 2023-05-15T15:09:52+02:00 Syringic acid improves oxidative stress and mitochondrial biogenesis in the liver of streptozotocin-induced diabetic rats Zahra Sabahi Mohammad Javad Khoshnoud Bahman Khalvati Seyedeh-Sara Hashemi Zahra Ghasempour Farsani Hoda Mogholi Gerashi Marzieh Rashedinia 2020-01-01T00:00:00Z https://doi.org/10.4103/2221-1691.276317 https://doaj.org/article/84c3d8c0aa8f4f70952c003a32116e18 EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2020;volume=10;issue=3;spage=111;epage=119;aulast=Sabahi https://doaj.org/toc/2588-9222 2588-9222 doi:10.4103/2221-1691.276317 https://doaj.org/article/84c3d8c0aa8f4f70952c003a32116e18 Asian Pacific Journal of Tropical Biomedicine, Vol 10, Iss 3, Pp 111-119 (2020) syringic acid diabetic liver oxidative stress mitochondrial biogenesis rats Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2020 ftdoajarticles https://doi.org/10.4103/2221-1691.276317 2022-12-31T10:56:16Z Objective: To determine the effects of syringic acid on hepatic damage in diabetic rats. Methods: Diabetes was induced by streptozotocin. Diabetic rats were given syringic acid at doses of 25, 50 and 100 mg/kg by oral gavage for 6 weeks. Syringic acid effects on the liver were evaluated by examination of plasma biochemical parameters, and pathological study. In addition, biomarkers of lipid peroxidation and antioxidant status of liver tissues were assessed. Real time-PCR was performed to investigate the mRNA expression levels of mitochondrial biogenesis indices in different groups. Results: Syringic acid significantly attenuated the increase in most of plasma biochemical parameters in diabetic rats. Moreover, syringic acid treatment increased the catalase activity while it reduced the superoxide dismutase activity and hepatic malondialdehyde level in diabetic rats. There was no difference between the glutathione content of the treated and untreated groups. These findings were supported by alleviation of histopathological damages in the syringic acid-treated groups compared to the untreated diabetic group. Syringic acid also significantly up-regulated the hepatic mRNA expression of PGC-1a, NRF-1, and NRF-2 and increased the mtDNA/nDNA ratio in diabetic rats. Conclusions: Syringic acid can be considered as a suitable candidate against hepatic complications since it can reduce oxidative damages in diabetic cases. Furthermore, it has the potential of targeting hepatic mitochondria in diabetes. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 10 3 111 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
syringic acid diabetic liver oxidative stress mitochondrial biogenesis rats Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
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syringic acid diabetic liver oxidative stress mitochondrial biogenesis rats Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Zahra Sabahi Mohammad Javad Khoshnoud Bahman Khalvati Seyedeh-Sara Hashemi Zahra Ghasempour Farsani Hoda Mogholi Gerashi Marzieh Rashedinia Syringic acid improves oxidative stress and mitochondrial biogenesis in the liver of streptozotocin-induced diabetic rats |
topic_facet |
syringic acid diabetic liver oxidative stress mitochondrial biogenesis rats Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To determine the effects of syringic acid on hepatic damage in diabetic rats. Methods: Diabetes was induced by streptozotocin. Diabetic rats were given syringic acid at doses of 25, 50 and 100 mg/kg by oral gavage for 6 weeks. Syringic acid effects on the liver were evaluated by examination of plasma biochemical parameters, and pathological study. In addition, biomarkers of lipid peroxidation and antioxidant status of liver tissues were assessed. Real time-PCR was performed to investigate the mRNA expression levels of mitochondrial biogenesis indices in different groups. Results: Syringic acid significantly attenuated the increase in most of plasma biochemical parameters in diabetic rats. Moreover, syringic acid treatment increased the catalase activity while it reduced the superoxide dismutase activity and hepatic malondialdehyde level in diabetic rats. There was no difference between the glutathione content of the treated and untreated groups. These findings were supported by alleviation of histopathological damages in the syringic acid-treated groups compared to the untreated diabetic group. Syringic acid also significantly up-regulated the hepatic mRNA expression of PGC-1a, NRF-1, and NRF-2 and increased the mtDNA/nDNA ratio in diabetic rats. Conclusions: Syringic acid can be considered as a suitable candidate against hepatic complications since it can reduce oxidative damages in diabetic cases. Furthermore, it has the potential of targeting hepatic mitochondria in diabetes. |
format |
Article in Journal/Newspaper |
author |
Zahra Sabahi Mohammad Javad Khoshnoud Bahman Khalvati Seyedeh-Sara Hashemi Zahra Ghasempour Farsani Hoda Mogholi Gerashi Marzieh Rashedinia |
author_facet |
Zahra Sabahi Mohammad Javad Khoshnoud Bahman Khalvati Seyedeh-Sara Hashemi Zahra Ghasempour Farsani Hoda Mogholi Gerashi Marzieh Rashedinia |
author_sort |
Zahra Sabahi |
title |
Syringic acid improves oxidative stress and mitochondrial biogenesis in the liver of streptozotocin-induced diabetic rats |
title_short |
Syringic acid improves oxidative stress and mitochondrial biogenesis in the liver of streptozotocin-induced diabetic rats |
title_full |
Syringic acid improves oxidative stress and mitochondrial biogenesis in the liver of streptozotocin-induced diabetic rats |
title_fullStr |
Syringic acid improves oxidative stress and mitochondrial biogenesis in the liver of streptozotocin-induced diabetic rats |
title_full_unstemmed |
Syringic acid improves oxidative stress and mitochondrial biogenesis in the liver of streptozotocin-induced diabetic rats |
title_sort |
syringic acid improves oxidative stress and mitochondrial biogenesis in the liver of streptozotocin-induced diabetic rats |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2020 |
url |
https://doi.org/10.4103/2221-1691.276317 https://doaj.org/article/84c3d8c0aa8f4f70952c003a32116e18 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 10, Iss 3, Pp 111-119 (2020) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2020;volume=10;issue=3;spage=111;epage=119;aulast=Sabahi https://doaj.org/toc/2588-9222 2588-9222 doi:10.4103/2221-1691.276317 https://doaj.org/article/84c3d8c0aa8f4f70952c003a32116e18 |
op_doi |
https://doi.org/10.4103/2221-1691.276317 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
10 |
container_issue |
3 |
container_start_page |
111 |
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1766340966143229952 |