Secondary metabolites and their biological activities in Indonesian soft coral of the genus Lobophytum

• Published in: Asian Pacific Journal of Tropical Biomedicine
• Main Authors: Masteria Yunovilsa Putra, Tutik Murniasih, Respati Tri Swasono, Joko Tri Wibowo, Annissa Nur Cahya Saputri, Meilia Rahma Widhiana, Irma Shita Arlyza
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wolters Kluwer Medknow Publications 2016
• Subjects: Ocean; Indonesia; Natural products; Biological activities; Arctic medicine. Tropical medicine; RC955-962; Biology (General); QH301-705.5; Arctic
• Online Access: https://doi.org/10.1016/j.apjtb.2016.08.011; https://doaj.org/article/8494fd840c4d4cd2adbfd156a5437dc1

Objective: To investigate the antioxidant, antibacterial, antimalarial activities and cytotoxicity of the n-hexane, ethyl acetate, n-butanol, and aqueous fractions from a crude extract of Lobophytum sp. Methods: This organism was collected from the Selayar Islands (South Sulawesi). The antioxidant activity was performed by the 1,1-diphenyl-2-picryl hydrazyl radical scavenging method. All fractions from the crude extract of Lobophytum sp. were examined for their cytotoxicity using the brine shrimp lethality bioassay and heme polymerization inhibitory activity assay for antimalarial activity. Results: It was found that the ethyl acetate, n-butanol and aqueous fractions exhibited heme polymerization inhibitory activity with IC50 values of 11.7, 14.3 and 12.0 μg/mL, respectively, while the n-butanol fraction showed moderate antioxidant activity and cytotoxicity with IC50 values of 150.00 and 92.74 μg/mL, respectively. Conclusions: This study provides information on antioxidant, antibacterial and antimalarial activities as well as the cytotoxicity of all fractions from the crude extract of Lobophytum sp. This is a new report of antimalarial substances derived from Lobophytum sp.