The influence of CD 4+t cells, hiv disease stage and zidovudine on hiv isolation in Bahia, Brazil

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Carlos Brites, Célia Pedroso, Nanci Silva, Warren D Johnson Jr, Roberto Badaró
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 1996
• Subjects: VIH; p24; Isolamento viral; Brasil; CD4+ linfócitos T; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/S0037-86821996000100002; https://doaj.org/article/8494458eda3c4a46a5c4db0cfd6a7690

HIV-l isolation was attempted on 72 individuais, including persons with knoum HIV infection and five without proven HIV infection but with indeterminate Western blot patterns, as well as on low-risk HIV seronegative persons. The ahility to detect HIV- 1 frorn culture supernatant by p24 antigen capture assay was evaluated by segregating patients by absolute CD4+ cell counts, clinicai stage of disease, p24 antigenemia and zidovudine use. The likelihood of a p24 positive HIV culture was highest among patients with CD4+ T-cell counts below 200/ul and patients with advanced clinical disease. Use of zidovudine did not affect the rate ofHIV positwity in cultures.