HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya
Abstract Background HIV infection is associated with more frequent and severe episodes of malaria and may be the result of altered malaria-specific B cell responses. However, it is poorly understood how HIV and the associated lymphopenia and immune activation affect malaria-specific antibody respons...
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ftdoajarticles:oai:doaj.org/article:843cd6f8d8c34b3284f791aa085168e3 2023-05-15T15:18:26+02:00 HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya Eliud O. Odhiambo Dibyadyuti Datta Bernard Guyah George Ayodo Bartholomew N. Ondigo Benard O. Abong’o Chandy C. John Anne E. P. Frosch 2019-08-01T00:00:00Z https://doi.org/10.1186/s12936-019-2915-7 https://doaj.org/article/843cd6f8d8c34b3284f791aa085168e3 EN eng BMC http://link.springer.com/article/10.1186/s12936-019-2915-7 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2915-7 1475-2875 https://doaj.org/article/843cd6f8d8c34b3284f791aa085168e3 Malaria Journal, Vol 18, Iss 1, Pp 1-10 (2019) HIV Plasmodium falciparum Antibodies Immune activation Viral load CRP Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2019 ftdoajarticles https://doi.org/10.1186/s12936-019-2915-7 2022-12-31T05:10:21Z Abstract Background HIV infection is associated with more frequent and severe episodes of malaria and may be the result of altered malaria-specific B cell responses. However, it is poorly understood how HIV and the associated lymphopenia and immune activation affect malaria-specific antibody responses. Methods HIV infected and uninfected adults were recruited from Bondo subcounty hospital in Western Kenya at the time of HIV testing (antiretroviral and co-trimoxazole prophylaxis naïve). Total and Plasmodium falciparum apical membrane antigen-1 (AMA1) and glutamate rich protein-R0 (GLURP-R0) specific IgM, IgG and IgG subclass concentrations was measured in 129 and 52 of recruited HIV-infected and uninfected individuals, respectively. In addition, HIV-1 viral load (VL), CD4+ T cell count, and C-reactive protein (CRP) concentration was quantified in study participants. Antibody levels were compared based on HIV status and the associations of antibody concentration with HIV-1 VL, CD4+ count, and CRP levels was measured using Spearman correlation testing. Results Among study participants, concentrations of IgM, IgG1 and IgG3 antibodies to AMA1 and GLURP-R0 were higher in HIV infected individuals compared to uninfected individuals (all p < 0.001). The IgG3 to IgG1 ratio to both AMA1 and GLURP-R0 was also significantly higher in HIV-infected individuals (p = 0.02). In HIV-infected participants, HIV-1 VL and CRP were weakly correlated with AMA1 and GLURP-R0 specific IgM and IgG1 concentrations and total (not antigen specific) IgM, IgG, IgG1, and IgG3 concentrations (all p < 0.05), suggesting that these changes are related in part to viral load and inflammation. Conclusions Overall, HIV infection leads to a total and malaria antigen-specific immunoglobulin production bias towards higher levels of IgM, IgG1, and IgG3, and HIV-1 viraemia and systemic inflammation are weakly correlated with these changes. Further assessments of antibody affinity and function and correlation with risk of clinical malaria, will help to ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 18 1 |
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English |
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HIV Plasmodium falciparum Antibodies Immune activation Viral load CRP Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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HIV Plasmodium falciparum Antibodies Immune activation Viral load CRP Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Eliud O. Odhiambo Dibyadyuti Datta Bernard Guyah George Ayodo Bartholomew N. Ondigo Benard O. Abong’o Chandy C. John Anne E. P. Frosch HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya |
topic_facet |
HIV Plasmodium falciparum Antibodies Immune activation Viral load CRP Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background HIV infection is associated with more frequent and severe episodes of malaria and may be the result of altered malaria-specific B cell responses. However, it is poorly understood how HIV and the associated lymphopenia and immune activation affect malaria-specific antibody responses. Methods HIV infected and uninfected adults were recruited from Bondo subcounty hospital in Western Kenya at the time of HIV testing (antiretroviral and co-trimoxazole prophylaxis naïve). Total and Plasmodium falciparum apical membrane antigen-1 (AMA1) and glutamate rich protein-R0 (GLURP-R0) specific IgM, IgG and IgG subclass concentrations was measured in 129 and 52 of recruited HIV-infected and uninfected individuals, respectively. In addition, HIV-1 viral load (VL), CD4+ T cell count, and C-reactive protein (CRP) concentration was quantified in study participants. Antibody levels were compared based on HIV status and the associations of antibody concentration with HIV-1 VL, CD4+ count, and CRP levels was measured using Spearman correlation testing. Results Among study participants, concentrations of IgM, IgG1 and IgG3 antibodies to AMA1 and GLURP-R0 were higher in HIV infected individuals compared to uninfected individuals (all p < 0.001). The IgG3 to IgG1 ratio to both AMA1 and GLURP-R0 was also significantly higher in HIV-infected individuals (p = 0.02). In HIV-infected participants, HIV-1 VL and CRP were weakly correlated with AMA1 and GLURP-R0 specific IgM and IgG1 concentrations and total (not antigen specific) IgM, IgG, IgG1, and IgG3 concentrations (all p < 0.05), suggesting that these changes are related in part to viral load and inflammation. Conclusions Overall, HIV infection leads to a total and malaria antigen-specific immunoglobulin production bias towards higher levels of IgM, IgG1, and IgG3, and HIV-1 viraemia and systemic inflammation are weakly correlated with these changes. Further assessments of antibody affinity and function and correlation with risk of clinical malaria, will help to ... |
format |
Article in Journal/Newspaper |
author |
Eliud O. Odhiambo Dibyadyuti Datta Bernard Guyah George Ayodo Bartholomew N. Ondigo Benard O. Abong’o Chandy C. John Anne E. P. Frosch |
author_facet |
Eliud O. Odhiambo Dibyadyuti Datta Bernard Guyah George Ayodo Bartholomew N. Ondigo Benard O. Abong’o Chandy C. John Anne E. P. Frosch |
author_sort |
Eliud O. Odhiambo |
title |
HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya |
title_short |
HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya |
title_full |
HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya |
title_fullStr |
HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya |
title_full_unstemmed |
HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya |
title_sort |
hiv infection drives igm and igg3 subclass bias in plasmodium falciparum-specific and total immunoglobulin concentration in western kenya |
publisher |
BMC |
publishDate |
2019 |
url |
https://doi.org/10.1186/s12936-019-2915-7 https://doaj.org/article/843cd6f8d8c34b3284f791aa085168e3 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 18, Iss 1, Pp 1-10 (2019) |
op_relation |
http://link.springer.com/article/10.1186/s12936-019-2915-7 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2915-7 1475-2875 https://doaj.org/article/843cd6f8d8c34b3284f791aa085168e3 |
op_doi |
https://doi.org/10.1186/s12936-019-2915-7 |
container_title |
Malaria Journal |
container_volume |
18 |
container_issue |
1 |
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1766348625594548224 |