The chemical defensome of five model teleost fish
Abstract How an organism copes with chemicals is largely determined by the genes and proteins that collectively function to defend against, detoxify and eliminate chemical stressors. This integrative network includes receptors and transcription factors, biotransformation enzymes, transporters, antio...
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ftdoajarticles:oai:doaj.org/article:8427bd82a1dc4576a2ec6d9270890131 2023-05-15T15:27:18+02:00 The chemical defensome of five model teleost fish Marta Eide Xiaokang Zhang Odd André Karlsen Jared V. Goldstone John Stegeman Inge Jonassen Anders Goksøyr 2021-05-01T00:00:00Z https://doi.org/10.1038/s41598-021-89948-0 https://doaj.org/article/8427bd82a1dc4576a2ec6d9270890131 EN eng Nature Portfolio https://doi.org/10.1038/s41598-021-89948-0 https://doaj.org/toc/2045-2322 doi:10.1038/s41598-021-89948-0 2045-2322 https://doaj.org/article/8427bd82a1dc4576a2ec6d9270890131 Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) Medicine R Science Q article 2021 ftdoajarticles https://doi.org/10.1038/s41598-021-89948-0 2022-12-31T07:18:17Z Abstract How an organism copes with chemicals is largely determined by the genes and proteins that collectively function to defend against, detoxify and eliminate chemical stressors. This integrative network includes receptors and transcription factors, biotransformation enzymes, transporters, antioxidants, and metal- and heat-responsive genes, and is collectively known as the chemical defensome. Teleost fish is the largest group of vertebrate species and can provide valuable insights into the evolution and functional diversity of defensome genes. We have previously shown that the xenosensing pregnane x receptor (pxr, nr1i2) is lost in many teleost species, including Atlantic cod (Gadus morhua) and three-spined stickleback (Gasterosteus aculeatus), but it is not known if compensatory mechanisms or signaling pathways have evolved in its absence. In this study, we compared the genes comprising the chemical defensome of five fish species that span the teleosteii evolutionary branch often used as model species in toxicological studies and environmental monitoring programs: zebrafish (Danio rerio), medaka (Oryzias latipes), Atlantic killifish (Fundulus heteroclitus), Atlantic cod, and three-spined stickleback. Genome mining revealed evolved differences in the number and composition of defensome genes that can have implication for how these species sense and respond to environmental pollutants, but we did not observe any candidates of compensatory mechanisms or pathways in cod and stickleback in the absence of pxr. The results indicate that knowledge regarding the diversity and function of the defensome will be important for toxicological testing and risk assessment studies. Article in Journal/Newspaper atlantic cod Gadus morhua Directory of Open Access Journals: DOAJ Articles Scientific Reports 11 1 |
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Medicine R Science Q |
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Medicine R Science Q Marta Eide Xiaokang Zhang Odd André Karlsen Jared V. Goldstone John Stegeman Inge Jonassen Anders Goksøyr The chemical defensome of five model teleost fish |
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Medicine R Science Q |
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Abstract How an organism copes with chemicals is largely determined by the genes and proteins that collectively function to defend against, detoxify and eliminate chemical stressors. This integrative network includes receptors and transcription factors, biotransformation enzymes, transporters, antioxidants, and metal- and heat-responsive genes, and is collectively known as the chemical defensome. Teleost fish is the largest group of vertebrate species and can provide valuable insights into the evolution and functional diversity of defensome genes. We have previously shown that the xenosensing pregnane x receptor (pxr, nr1i2) is lost in many teleost species, including Atlantic cod (Gadus morhua) and three-spined stickleback (Gasterosteus aculeatus), but it is not known if compensatory mechanisms or signaling pathways have evolved in its absence. In this study, we compared the genes comprising the chemical defensome of five fish species that span the teleosteii evolutionary branch often used as model species in toxicological studies and environmental monitoring programs: zebrafish (Danio rerio), medaka (Oryzias latipes), Atlantic killifish (Fundulus heteroclitus), Atlantic cod, and three-spined stickleback. Genome mining revealed evolved differences in the number and composition of defensome genes that can have implication for how these species sense and respond to environmental pollutants, but we did not observe any candidates of compensatory mechanisms or pathways in cod and stickleback in the absence of pxr. The results indicate that knowledge regarding the diversity and function of the defensome will be important for toxicological testing and risk assessment studies. |
format |
Article in Journal/Newspaper |
author |
Marta Eide Xiaokang Zhang Odd André Karlsen Jared V. Goldstone John Stegeman Inge Jonassen Anders Goksøyr |
author_facet |
Marta Eide Xiaokang Zhang Odd André Karlsen Jared V. Goldstone John Stegeman Inge Jonassen Anders Goksøyr |
author_sort |
Marta Eide |
title |
The chemical defensome of five model teleost fish |
title_short |
The chemical defensome of five model teleost fish |
title_full |
The chemical defensome of five model teleost fish |
title_fullStr |
The chemical defensome of five model teleost fish |
title_full_unstemmed |
The chemical defensome of five model teleost fish |
title_sort |
chemical defensome of five model teleost fish |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doi.org/10.1038/s41598-021-89948-0 https://doaj.org/article/8427bd82a1dc4576a2ec6d9270890131 |
genre |
atlantic cod Gadus morhua |
genre_facet |
atlantic cod Gadus morhua |
op_source |
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) |
op_relation |
https://doi.org/10.1038/s41598-021-89948-0 https://doaj.org/toc/2045-2322 doi:10.1038/s41598-021-89948-0 2045-2322 https://doaj.org/article/8427bd82a1dc4576a2ec6d9270890131 |
op_doi |
https://doi.org/10.1038/s41598-021-89948-0 |
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Scientific Reports |
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11 |
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1 |
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1766357752224940032 |