The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya
There is inadequate understanding of the epidemiology of Non-Tuberculous Mycobacteria (NTM) among infants in high tuberculosis burden countries. The objective of this study was to document the incidence and diversity of NTM disease or colonisation in sputum specimens from infants with presumptive TB...
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ftdoajarticles:oai:doaj.org/article:8426aebc04624a17a7da164ad8416486 2023-05-15T15:08:58+02:00 The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya Grace Kaguthi Videlis Nduba Wilfred Murithi Suzanne Verver 2019-01-01T00:00:00Z https://doi.org/10.1155/2019/1273235 https://doaj.org/article/8426aebc04624a17a7da164ad8416486 EN eng Hindawi Limited http://dx.doi.org/10.1155/2019/1273235 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2019/1273235 https://doaj.org/article/8426aebc04624a17a7da164ad8416486 Journal of Tropical Medicine, Vol 2019 (2019) Arctic medicine. Tropical medicine RC955-962 article 2019 ftdoajarticles https://doi.org/10.1155/2019/1273235 2022-12-31T11:16:57Z There is inadequate understanding of the epidemiology of Non-Tuberculous Mycobacteria (NTM) among infants in high tuberculosis burden countries. The objective of this study was to document the incidence and diversity of NTM disease or colonisation in sputum specimens from infants with presumptive TB, the risk factors, and clinical characteristics, in a high TB and HIV burden setting in Western Kenya. A cohort of 2900 newborns was followed for 1–2 years to assess TB incidence. TB investigations included collection of induced sputa and gastric aspirates for culture and speciation by HAIN®, Tuberculin Skin Testing (TST), HIV testing, and chest radiography. The American Thoracic Society Criteria (ATS) were applied to identify NTM disease. Among 927 (32% of 2900) with presumptive TB, 742 (80%) were investigated. NTM were isolated from 19/742 (2.6%) infants. M. fortuitum was most frequently speciated (32%). Total person-time was 3330 years. NTM incidence was 5.7/1,000 person-years, 95% CI (3.5, 8.7). Infants diagnosed with TB were more likely to have NTM isolation (odds ratio 11.5; 95% CI 3.25, 41.0). None of the infants with NTM isolated met the criteria for NTM disease. The incidence of NTM isolation was comparable to similar studies in Africa. NTM isolation did not meet ATS criteria for disease and could represent colonisation. TB disease appears to be structural lung disease predisposing to NTM colonisation. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2019 1 10 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Grace Kaguthi Videlis Nduba Wilfred Murithi Suzanne Verver The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
There is inadequate understanding of the epidemiology of Non-Tuberculous Mycobacteria (NTM) among infants in high tuberculosis burden countries. The objective of this study was to document the incidence and diversity of NTM disease or colonisation in sputum specimens from infants with presumptive TB, the risk factors, and clinical characteristics, in a high TB and HIV burden setting in Western Kenya. A cohort of 2900 newborns was followed for 1–2 years to assess TB incidence. TB investigations included collection of induced sputa and gastric aspirates for culture and speciation by HAIN®, Tuberculin Skin Testing (TST), HIV testing, and chest radiography. The American Thoracic Society Criteria (ATS) were applied to identify NTM disease. Among 927 (32% of 2900) with presumptive TB, 742 (80%) were investigated. NTM were isolated from 19/742 (2.6%) infants. M. fortuitum was most frequently speciated (32%). Total person-time was 3330 years. NTM incidence was 5.7/1,000 person-years, 95% CI (3.5, 8.7). Infants diagnosed with TB were more likely to have NTM isolation (odds ratio 11.5; 95% CI 3.25, 41.0). None of the infants with NTM isolated met the criteria for NTM disease. The incidence of NTM isolation was comparable to similar studies in Africa. NTM isolation did not meet ATS criteria for disease and could represent colonisation. TB disease appears to be structural lung disease predisposing to NTM colonisation. |
format |
Article in Journal/Newspaper |
author |
Grace Kaguthi Videlis Nduba Wilfred Murithi Suzanne Verver |
author_facet |
Grace Kaguthi Videlis Nduba Wilfred Murithi Suzanne Verver |
author_sort |
Grace Kaguthi |
title |
The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya |
title_short |
The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya |
title_full |
The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya |
title_fullStr |
The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya |
title_full_unstemmed |
The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya |
title_sort |
incidence of non-tuberculous mycobacteria in infants in kenya |
publisher |
Hindawi Limited |
publishDate |
2019 |
url |
https://doi.org/10.1155/2019/1273235 https://doaj.org/article/8426aebc04624a17a7da164ad8416486 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2019 (2019) |
op_relation |
http://dx.doi.org/10.1155/2019/1273235 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2019/1273235 https://doaj.org/article/8426aebc04624a17a7da164ad8416486 |
op_doi |
https://doi.org/10.1155/2019/1273235 |
container_title |
Journal of Tropical Medicine |
container_volume |
2019 |
container_start_page |
1 |
op_container_end_page |
10 |
_version_ |
1766340225201602560 |