Early control of viral load by favipiravir promotes survival to Ebola virus challenge and prevents cytokine storm in non-human primates.
Ebola virus has been responsible for two major epidemics over the last several years and there has been a strong effort to find potential treatments that can improve the disease outcome. Antiviral favipiravir was thus tested on non-human primates infected with Ebola virus. Half of the treated animal...
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Online Access: | https://doi.org/10.1371/journal.pntd.0009300 https://doaj.org/article/83f0b0b6212d4887b5b86a6b168294a4 |
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ftdoajarticles:oai:doaj.org/article:83f0b0b6212d4887b5b86a6b168294a4 2023-05-15T15:04:59+02:00 Early control of viral load by favipiravir promotes survival to Ebola virus challenge and prevents cytokine storm in non-human primates. Stéphanie Reynard Emilie Gloaguen Nicolas Baillet Vincent Madelain Jérémie Guedj Hervé Raoul Xavier de Lamballerie Jimmy Mullaert Sylvain Baize 2021-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009300 https://doaj.org/article/83f0b0b6212d4887b5b86a6b168294a4 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009300 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009300 https://doaj.org/article/83f0b0b6212d4887b5b86a6b168294a4 PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009300 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009300 2022-12-31T11:49:06Z Ebola virus has been responsible for two major epidemics over the last several years and there has been a strong effort to find potential treatments that can improve the disease outcome. Antiviral favipiravir was thus tested on non-human primates infected with Ebola virus. Half of the treated animals survived the Ebola virus challenge, whereas the infection was fully lethal for the untreated ones. Moreover, the treated animals that did not survive died later than the controls. We evaluated the hematological, virological, biochemical, and immunological parameters of the animals and performed proteomic analysis at various timepoints of the disease. The viral load strongly correlated with dysregulation of the biological functions involved in pathogenesis, notably the inflammatory response, hemostatic functions, and response to stress. Thus, the management of viral replication in Ebola virus disease is of crucial importance in preventing the immunopathogenic disorders and septic-like shock syndrome generally observed in Ebola virus-infected patients. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 3 e0009300 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Stéphanie Reynard Emilie Gloaguen Nicolas Baillet Vincent Madelain Jérémie Guedj Hervé Raoul Xavier de Lamballerie Jimmy Mullaert Sylvain Baize Early control of viral load by favipiravir promotes survival to Ebola virus challenge and prevents cytokine storm in non-human primates. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Ebola virus has been responsible for two major epidemics over the last several years and there has been a strong effort to find potential treatments that can improve the disease outcome. Antiviral favipiravir was thus tested on non-human primates infected with Ebola virus. Half of the treated animals survived the Ebola virus challenge, whereas the infection was fully lethal for the untreated ones. Moreover, the treated animals that did not survive died later than the controls. We evaluated the hematological, virological, biochemical, and immunological parameters of the animals and performed proteomic analysis at various timepoints of the disease. The viral load strongly correlated with dysregulation of the biological functions involved in pathogenesis, notably the inflammatory response, hemostatic functions, and response to stress. Thus, the management of viral replication in Ebola virus disease is of crucial importance in preventing the immunopathogenic disorders and septic-like shock syndrome generally observed in Ebola virus-infected patients. |
format |
Article in Journal/Newspaper |
author |
Stéphanie Reynard Emilie Gloaguen Nicolas Baillet Vincent Madelain Jérémie Guedj Hervé Raoul Xavier de Lamballerie Jimmy Mullaert Sylvain Baize |
author_facet |
Stéphanie Reynard Emilie Gloaguen Nicolas Baillet Vincent Madelain Jérémie Guedj Hervé Raoul Xavier de Lamballerie Jimmy Mullaert Sylvain Baize |
author_sort |
Stéphanie Reynard |
title |
Early control of viral load by favipiravir promotes survival to Ebola virus challenge and prevents cytokine storm in non-human primates. |
title_short |
Early control of viral load by favipiravir promotes survival to Ebola virus challenge and prevents cytokine storm in non-human primates. |
title_full |
Early control of viral load by favipiravir promotes survival to Ebola virus challenge and prevents cytokine storm in non-human primates. |
title_fullStr |
Early control of viral load by favipiravir promotes survival to Ebola virus challenge and prevents cytokine storm in non-human primates. |
title_full_unstemmed |
Early control of viral load by favipiravir promotes survival to Ebola virus challenge and prevents cytokine storm in non-human primates. |
title_sort |
early control of viral load by favipiravir promotes survival to ebola virus challenge and prevents cytokine storm in non-human primates. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009300 https://doaj.org/article/83f0b0b6212d4887b5b86a6b168294a4 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009300 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009300 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009300 https://doaj.org/article/83f0b0b6212d4887b5b86a6b168294a4 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009300 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
15 |
container_issue |
3 |
container_start_page |
e0009300 |
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1766336755688013824 |