Diagnosis of Schistosoma infection in non-human animal hosts: A systematic review and meta-analysis.
Background Reliable and field-applicable diagnosis of schistosome infections in non-human animals is important for surveillance, control, and verification of interruption of human schistosomiasis transmission. This study aimed to summarize uses of available diagnostic techniques through a systematic...
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ftdoajarticles:oai:doaj.org/article:83be60c3aeff43e7b82a140b9d56c058 2023-05-15T15:10:16+02:00 Diagnosis of Schistosoma infection in non-human animal hosts: A systematic review and meta-analysis. Song Liang Keerati Ponpetch Yi-Biao Zhou Jiagang Guo Berhanu Erko J Russell Stothard M Hassan Murad Xiao-Nong Zhou Fadjar Satrija Joanne P Webster Justin V Remais Jürg Utzinger Amadou Garba 2022-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010389 https://doaj.org/article/83be60c3aeff43e7b82a140b9d56c058 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010389 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010389 https://doaj.org/article/83be60c3aeff43e7b82a140b9d56c058 PLoS Neglected Tropical Diseases, Vol 16, Iss 5, p e0010389 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010389 2023-01-15T01:24:08Z Background Reliable and field-applicable diagnosis of schistosome infections in non-human animals is important for surveillance, control, and verification of interruption of human schistosomiasis transmission. This study aimed to summarize uses of available diagnostic techniques through a systematic review and meta-analysis. Methodology and principal findings We systematically searched the literature and reports comparing two or more diagnostic tests in non-human animals for schistosome infection. Out of 4,909 articles and reports screened, 19 met our inclusion criteria, four of which were considered in the meta-analysis. A total of 14 techniques (parasitologic, immunologic, and molecular) and nine types of non-human animals were involved in the studies. Notably, four studies compared parasitologic tests (miracidium hatching test (MHT), Kato-Katz (KK), the Danish Bilharziasis Laboratory technique (DBL), and formalin-ethyl acetate sedimentation-digestion (FEA-SD)) with quantitative polymerase chain reaction (qPCR), and sensitivity estimates (using qPCR as the reference) were extracted and included in the meta-analyses, showing significant heterogeneity across studies and animal hosts. The pooled estimate of sensitivity was 0.21 (95% confidence interval (CI): 0.03-0.48) with FEA-SD showing highest sensitivity (0.89, 95% CI: 0.65-1.00). Conclusions/significance Our findings suggest that the parasitologic technique FEA-SD and the molecular technique qPCR are the most promising techniques for schistosome diagnosis in non-human animal hosts. Future studies are needed for validation and standardization of the techniques for real-world field applications. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 16 5 e0010389 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Song Liang Keerati Ponpetch Yi-Biao Zhou Jiagang Guo Berhanu Erko J Russell Stothard M Hassan Murad Xiao-Nong Zhou Fadjar Satrija Joanne P Webster Justin V Remais Jürg Utzinger Amadou Garba Diagnosis of Schistosoma infection in non-human animal hosts: A systematic review and meta-analysis. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Reliable and field-applicable diagnosis of schistosome infections in non-human animals is important for surveillance, control, and verification of interruption of human schistosomiasis transmission. This study aimed to summarize uses of available diagnostic techniques through a systematic review and meta-analysis. Methodology and principal findings We systematically searched the literature and reports comparing two or more diagnostic tests in non-human animals for schistosome infection. Out of 4,909 articles and reports screened, 19 met our inclusion criteria, four of which were considered in the meta-analysis. A total of 14 techniques (parasitologic, immunologic, and molecular) and nine types of non-human animals were involved in the studies. Notably, four studies compared parasitologic tests (miracidium hatching test (MHT), Kato-Katz (KK), the Danish Bilharziasis Laboratory technique (DBL), and formalin-ethyl acetate sedimentation-digestion (FEA-SD)) with quantitative polymerase chain reaction (qPCR), and sensitivity estimates (using qPCR as the reference) were extracted and included in the meta-analyses, showing significant heterogeneity across studies and animal hosts. The pooled estimate of sensitivity was 0.21 (95% confidence interval (CI): 0.03-0.48) with FEA-SD showing highest sensitivity (0.89, 95% CI: 0.65-1.00). Conclusions/significance Our findings suggest that the parasitologic technique FEA-SD and the molecular technique qPCR are the most promising techniques for schistosome diagnosis in non-human animal hosts. Future studies are needed for validation and standardization of the techniques for real-world field applications. |
format |
Article in Journal/Newspaper |
author |
Song Liang Keerati Ponpetch Yi-Biao Zhou Jiagang Guo Berhanu Erko J Russell Stothard M Hassan Murad Xiao-Nong Zhou Fadjar Satrija Joanne P Webster Justin V Remais Jürg Utzinger Amadou Garba |
author_facet |
Song Liang Keerati Ponpetch Yi-Biao Zhou Jiagang Guo Berhanu Erko J Russell Stothard M Hassan Murad Xiao-Nong Zhou Fadjar Satrija Joanne P Webster Justin V Remais Jürg Utzinger Amadou Garba |
author_sort |
Song Liang |
title |
Diagnosis of Schistosoma infection in non-human animal hosts: A systematic review and meta-analysis. |
title_short |
Diagnosis of Schistosoma infection in non-human animal hosts: A systematic review and meta-analysis. |
title_full |
Diagnosis of Schistosoma infection in non-human animal hosts: A systematic review and meta-analysis. |
title_fullStr |
Diagnosis of Schistosoma infection in non-human animal hosts: A systematic review and meta-analysis. |
title_full_unstemmed |
Diagnosis of Schistosoma infection in non-human animal hosts: A systematic review and meta-analysis. |
title_sort |
diagnosis of schistosoma infection in non-human animal hosts: a systematic review and meta-analysis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010389 https://doaj.org/article/83be60c3aeff43e7b82a140b9d56c058 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 5, p e0010389 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010389 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010389 https://doaj.org/article/83be60c3aeff43e7b82a140b9d56c058 |
op_doi |
https://doi.org/10.1371/journal.pntd.0010389 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
16 |
container_issue |
5 |
container_start_page |
e0010389 |
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1766341309816111104 |