Combined effectiveness of anthelmintic chemotherapy and WASH among HIV-infected adults.
Current global helminth control guidelines focus on regular deworming of targeted populations for morbidity control. However, water, sanitation, and hygiene (WASH) interventions may also be important for reducing helminth transmission. We evaluated the impact of different potential helminth protecti...
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ftdoajarticles:oai:doaj.org/article:82e96f98a0a7419d842f1a0f137efe79 2023-05-15T15:16:49+02:00 Combined effectiveness of anthelmintic chemotherapy and WASH among HIV-infected adults. Arianna R Means Lisette van Lieshout Eric Brienen Krista Yuhas James P Hughes Paul Ndungu Benson Singa Judd L Walson 2018-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005955 https://doaj.org/article/82e96f98a0a7419d842f1a0f137efe79 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5773082?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005955 https://doaj.org/article/82e96f98a0a7419d842f1a0f137efe79 PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0005955 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005955 2022-12-31T03:21:31Z Current global helminth control guidelines focus on regular deworming of targeted populations for morbidity control. However, water, sanitation, and hygiene (WASH) interventions may also be important for reducing helminth transmission. We evaluated the impact of different potential helminth protective packages on infection prevalence, including repeated treatment with albendazole and praziquantel with and without WASH access.We conducted a cohort study nested within a randomized trial of empiric deworming of HIV-infected adults in Kenya. Helminth infections and infection intensity were diagnosed using semi-quantitative real-time PCR. We conducted a manual forward stepwise model building approach to identify if there are packages of interventions that may be protective against an STH infection of any species (combined outcome) and each helminth species individually. We conducted secondary analyses using the same approach only amongst individuals with no anthelmintis exposure. We used interaction terms to test for potential intervention synergy. Approximately 22% of the 701 stool samples provided were helminth-infected, most of which were of low to moderate intensity. The odds of infection with any STH species were lower for individuals who were treated with albendazole (aOR:0.11, 95%CI: 0.05, 0.20, p<0.001), adjusting for age and sex. Although most WASH conditions demonstrated minimal additional benefit in reducing the probability of infection with any STH species, access to safe flooring did appear to offer some additional protection (aOR:0.34, 95%CI: 0.20, 0.56, p<0.001). For schistosomiasis, only treatment with praziquantel was protective (aOR:0.30 95%CI: 0.14, 0.60, p = 0.001). Amongst individuals who were not treated with albendazole or praziquantel, the most protective intervention package to reduce probability of STH infections included safe flooring (aOR:0.34, 95%CI: 0.20, 0.59, p<0.001) and latrine access (aOR:0.59, 95%CI: 0.35, 0.99, p = 0.05). Across all species, there was no evidence of ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 12 1 e0005955 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Arianna R Means Lisette van Lieshout Eric Brienen Krista Yuhas James P Hughes Paul Ndungu Benson Singa Judd L Walson Combined effectiveness of anthelmintic chemotherapy and WASH among HIV-infected adults. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Current global helminth control guidelines focus on regular deworming of targeted populations for morbidity control. However, water, sanitation, and hygiene (WASH) interventions may also be important for reducing helminth transmission. We evaluated the impact of different potential helminth protective packages on infection prevalence, including repeated treatment with albendazole and praziquantel with and without WASH access.We conducted a cohort study nested within a randomized trial of empiric deworming of HIV-infected adults in Kenya. Helminth infections and infection intensity were diagnosed using semi-quantitative real-time PCR. We conducted a manual forward stepwise model building approach to identify if there are packages of interventions that may be protective against an STH infection of any species (combined outcome) and each helminth species individually. We conducted secondary analyses using the same approach only amongst individuals with no anthelmintis exposure. We used interaction terms to test for potential intervention synergy. Approximately 22% of the 701 stool samples provided were helminth-infected, most of which were of low to moderate intensity. The odds of infection with any STH species were lower for individuals who were treated with albendazole (aOR:0.11, 95%CI: 0.05, 0.20, p<0.001), adjusting for age and sex. Although most WASH conditions demonstrated minimal additional benefit in reducing the probability of infection with any STH species, access to safe flooring did appear to offer some additional protection (aOR:0.34, 95%CI: 0.20, 0.56, p<0.001). For schistosomiasis, only treatment with praziquantel was protective (aOR:0.30 95%CI: 0.14, 0.60, p = 0.001). Amongst individuals who were not treated with albendazole or praziquantel, the most protective intervention package to reduce probability of STH infections included safe flooring (aOR:0.34, 95%CI: 0.20, 0.59, p<0.001) and latrine access (aOR:0.59, 95%CI: 0.35, 0.99, p = 0.05). Across all species, there was no evidence of ... |
format |
Article in Journal/Newspaper |
author |
Arianna R Means Lisette van Lieshout Eric Brienen Krista Yuhas James P Hughes Paul Ndungu Benson Singa Judd L Walson |
author_facet |
Arianna R Means Lisette van Lieshout Eric Brienen Krista Yuhas James P Hughes Paul Ndungu Benson Singa Judd L Walson |
author_sort |
Arianna R Means |
title |
Combined effectiveness of anthelmintic chemotherapy and WASH among HIV-infected adults. |
title_short |
Combined effectiveness of anthelmintic chemotherapy and WASH among HIV-infected adults. |
title_full |
Combined effectiveness of anthelmintic chemotherapy and WASH among HIV-infected adults. |
title_fullStr |
Combined effectiveness of anthelmintic chemotherapy and WASH among HIV-infected adults. |
title_full_unstemmed |
Combined effectiveness of anthelmintic chemotherapy and WASH among HIV-infected adults. |
title_sort |
combined effectiveness of anthelmintic chemotherapy and wash among hiv-infected adults. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0005955 https://doaj.org/article/82e96f98a0a7419d842f1a0f137efe79 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0005955 (2018) |
op_relation |
http://europepmc.org/articles/PMC5773082?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005955 https://doaj.org/article/82e96f98a0a7419d842f1a0f137efe79 |
op_doi |
https://doi.org/10.1371/journal.pntd.0005955 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
12 |
container_issue |
1 |
container_start_page |
e0005955 |
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1766347108422516736 |