Challenges for management of post kala-azar dermal leishmaniasis and future directions
Dinesh Mondal,1 Shinjiro Hamano,2 Md Golam Hasnain,1 Abhay R Satoskar3 1Centre for Nutrition and Food Security, Parasitology Laboratory, (icddr, b) Mohakhali, Dhaka, Bangladesh; 2Department of Parasitology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan; 3Departments o...
Main Authors: | , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Dove Medical Press
2014
|
Subjects: | |
Online Access: | https://doaj.org/article/828d795a82e84522a72b29c6c4f61765 |
id |
ftdoajarticles:oai:doaj.org/article:828d795a82e84522a72b29c6c4f61765 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:828d795a82e84522a72b29c6c4f61765 2023-05-15T15:08:34+02:00 Challenges for management of post kala-azar dermal leishmaniasis and future directions Mondal D Hamano S Hasnain MG Satoskar AR 2014-11-01T00:00:00Z https://doaj.org/article/828d795a82e84522a72b29c6c4f61765 EN eng Dove Medical Press http://www.dovepress.com/challenges-for-management-of-post-kala-azar-dermal-leishmaniasis-and-f-peer-reviewed-article-RRTM https://doaj.org/toc/1179-7282 1179-7282 https://doaj.org/article/828d795a82e84522a72b29c6c4f61765 Research and Reports in Tropical Medicine, Vol 2014, Iss default, Pp 105-111 (2014) Arctic medicine. Tropical medicine RC955-962 article 2014 ftdoajarticles 2022-12-31T01:48:09Z Dinesh Mondal,1 Shinjiro Hamano,2 Md Golam Hasnain,1 Abhay R Satoskar3 1Centre for Nutrition and Food Security, Parasitology Laboratory, (icddr, b) Mohakhali, Dhaka, Bangladesh; 2Department of Parasitology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan; 3Departments of Pathology and Microbiology, Wexner Medical Center, The Ohio State University, Columbus, OH, USA Abstract: Post kala-azar dermal leishmaniasis (PKDL) is a skin complication resulting from infection with Leishmania donovani (LD) parasite. It mostly affects individuals who have previously suffered from visceral leishmaniasis (VL) caused by LD. In some cases, PKDL develops among people infected with LD, but do not show any symptoms of VL. Clinical presentation includes hypopigmented macules/papules/nodules or polymorphic lesions (combination of two or more lesions). Except for skin lesions, PKDL patients are generally healthy and usually do not seek medical care. These patients play an important role in interepidemic transmission of the infection and subsequent VL outbreak. Therefore, proper diagnosis and treatment of PKDL patients is important for the control of VL in endemic countries, especially in the Indian subcontinent where VL is anthroponotic. Here, we report the challenges in the estimation of PKDL burden, its diagnosis, and treatment, and suggest possible solutions based on recent literature, reports, published manuals, and web-based information. Keywords: post kala-azar dermal leishmaniasis, Bangladesh, challenge, treatment, diagnosis, prevention Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Indian Azar ENVELOPE(-63.733,-63.733,-64.983,-64.983) |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Mondal D Hamano S Hasnain MG Satoskar AR Challenges for management of post kala-azar dermal leishmaniasis and future directions |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Dinesh Mondal,1 Shinjiro Hamano,2 Md Golam Hasnain,1 Abhay R Satoskar3 1Centre for Nutrition and Food Security, Parasitology Laboratory, (icddr, b) Mohakhali, Dhaka, Bangladesh; 2Department of Parasitology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan; 3Departments of Pathology and Microbiology, Wexner Medical Center, The Ohio State University, Columbus, OH, USA Abstract: Post kala-azar dermal leishmaniasis (PKDL) is a skin complication resulting from infection with Leishmania donovani (LD) parasite. It mostly affects individuals who have previously suffered from visceral leishmaniasis (VL) caused by LD. In some cases, PKDL develops among people infected with LD, but do not show any symptoms of VL. Clinical presentation includes hypopigmented macules/papules/nodules or polymorphic lesions (combination of two or more lesions). Except for skin lesions, PKDL patients are generally healthy and usually do not seek medical care. These patients play an important role in interepidemic transmission of the infection and subsequent VL outbreak. Therefore, proper diagnosis and treatment of PKDL patients is important for the control of VL in endemic countries, especially in the Indian subcontinent where VL is anthroponotic. Here, we report the challenges in the estimation of PKDL burden, its diagnosis, and treatment, and suggest possible solutions based on recent literature, reports, published manuals, and web-based information. Keywords: post kala-azar dermal leishmaniasis, Bangladesh, challenge, treatment, diagnosis, prevention |
format |
Article in Journal/Newspaper |
author |
Mondal D Hamano S Hasnain MG Satoskar AR |
author_facet |
Mondal D Hamano S Hasnain MG Satoskar AR |
author_sort |
Mondal D |
title |
Challenges for management of post kala-azar dermal leishmaniasis and future directions |
title_short |
Challenges for management of post kala-azar dermal leishmaniasis and future directions |
title_full |
Challenges for management of post kala-azar dermal leishmaniasis and future directions |
title_fullStr |
Challenges for management of post kala-azar dermal leishmaniasis and future directions |
title_full_unstemmed |
Challenges for management of post kala-azar dermal leishmaniasis and future directions |
title_sort |
challenges for management of post kala-azar dermal leishmaniasis and future directions |
publisher |
Dove Medical Press |
publishDate |
2014 |
url |
https://doaj.org/article/828d795a82e84522a72b29c6c4f61765 |
long_lat |
ENVELOPE(-63.733,-63.733,-64.983,-64.983) |
geographic |
Arctic Indian Azar |
geographic_facet |
Arctic Indian Azar |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Research and Reports in Tropical Medicine, Vol 2014, Iss default, Pp 105-111 (2014) |
op_relation |
http://www.dovepress.com/challenges-for-management-of-post-kala-azar-dermal-leishmaniasis-and-f-peer-reviewed-article-RRTM https://doaj.org/toc/1179-7282 1179-7282 https://doaj.org/article/828d795a82e84522a72b29c6c4f61765 |
_version_ |
1766339904584810496 |