Comparison of the performance of the CareStart Malaria Pf/Pan Combo test and field microscopy in the diagnosis of Plasmodium vivax malaria in North Sumatera, Indonesia
Abstract Background In areas where malaria is endemic and where trained microscopists are not available, rapid diagnostic tests (RDTs) are needed not only to allow prompt treatment without delay but also to prevent overdiagnosis and overtreatment based on clinical judgements that may lead to drug re...
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ftdoajarticles:oai:doaj.org/article:82808481dd0a472e9bc046152456c6c9 2023-05-15T15:09:46+02:00 Comparison of the performance of the CareStart Malaria Pf/Pan Combo test and field microscopy in the diagnosis of Plasmodium vivax malaria in North Sumatera, Indonesia Ayodhia Pitaloka Pasaribu Irma Sari Nasution Krisnarta Sembiring Fahmi Fahmi Syahril Pasaribu 2022-01-01T00:00:00Z https://doi.org/10.1186/s12936-022-04057-1 https://doaj.org/article/82808481dd0a472e9bc046152456c6c9 EN eng BMC https://doi.org/10.1186/s12936-022-04057-1 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-022-04057-1 1475-2875 https://doaj.org/article/82808481dd0a472e9bc046152456c6c9 Malaria Journal, Vol 21, Iss 1, Pp 1-6 (2022) CareStart Field microscopy Malaria Rapid diagnostic test Indonesia Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2022 ftdoajarticles https://doi.org/10.1186/s12936-022-04057-1 2022-12-31T15:11:00Z Abstract Background In areas where malaria is endemic and where trained microscopists are not available, rapid diagnostic tests (RDTs) are needed not only to allow prompt treatment without delay but also to prevent overdiagnosis and overtreatment based on clinical judgements that may lead to drug resistance. This study aimed to compare the performances of the CareStart Pf/Pan Combo test to field microscopy, which is considered to be the gold standard for malaria diagnosis. Methods Any person with a fever or a history of fever within 48 h who came to the health centre was recruited for the study and tested both by the CareStart Pf/Pan test and by field microscopy. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were analysed with both methods. Results Two-hundred study participants were enrolled: 96 (48%) were found to be positive through microscopy, while 100 (50%) participants were found to be positive through RDT. The RDT produced four false-positive results. High sensitivity and specificity were observed for the CareStart Pf/Pan test (100 and 96.15%, respectively). The CareStart Pf/Pan test also showed excellent agreement with the field microscopy results. Conclusion The Carestart Pf/Pan could be used as an alternative diagnostic test in malaria-endemic areas where facility for performing microscopy is not available. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 21 1 |
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English |
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CareStart Field microscopy Malaria Rapid diagnostic test Indonesia Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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CareStart Field microscopy Malaria Rapid diagnostic test Indonesia Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Ayodhia Pitaloka Pasaribu Irma Sari Nasution Krisnarta Sembiring Fahmi Fahmi Syahril Pasaribu Comparison of the performance of the CareStart Malaria Pf/Pan Combo test and field microscopy in the diagnosis of Plasmodium vivax malaria in North Sumatera, Indonesia |
topic_facet |
CareStart Field microscopy Malaria Rapid diagnostic test Indonesia Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background In areas where malaria is endemic and where trained microscopists are not available, rapid diagnostic tests (RDTs) are needed not only to allow prompt treatment without delay but also to prevent overdiagnosis and overtreatment based on clinical judgements that may lead to drug resistance. This study aimed to compare the performances of the CareStart Pf/Pan Combo test to field microscopy, which is considered to be the gold standard for malaria diagnosis. Methods Any person with a fever or a history of fever within 48 h who came to the health centre was recruited for the study and tested both by the CareStart Pf/Pan test and by field microscopy. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were analysed with both methods. Results Two-hundred study participants were enrolled: 96 (48%) were found to be positive through microscopy, while 100 (50%) participants were found to be positive through RDT. The RDT produced four false-positive results. High sensitivity and specificity were observed for the CareStart Pf/Pan test (100 and 96.15%, respectively). The CareStart Pf/Pan test also showed excellent agreement with the field microscopy results. Conclusion The Carestart Pf/Pan could be used as an alternative diagnostic test in malaria-endemic areas where facility for performing microscopy is not available. |
format |
Article in Journal/Newspaper |
author |
Ayodhia Pitaloka Pasaribu Irma Sari Nasution Krisnarta Sembiring Fahmi Fahmi Syahril Pasaribu |
author_facet |
Ayodhia Pitaloka Pasaribu Irma Sari Nasution Krisnarta Sembiring Fahmi Fahmi Syahril Pasaribu |
author_sort |
Ayodhia Pitaloka Pasaribu |
title |
Comparison of the performance of the CareStart Malaria Pf/Pan Combo test and field microscopy in the diagnosis of Plasmodium vivax malaria in North Sumatera, Indonesia |
title_short |
Comparison of the performance of the CareStart Malaria Pf/Pan Combo test and field microscopy in the diagnosis of Plasmodium vivax malaria in North Sumatera, Indonesia |
title_full |
Comparison of the performance of the CareStart Malaria Pf/Pan Combo test and field microscopy in the diagnosis of Plasmodium vivax malaria in North Sumatera, Indonesia |
title_fullStr |
Comparison of the performance of the CareStart Malaria Pf/Pan Combo test and field microscopy in the diagnosis of Plasmodium vivax malaria in North Sumatera, Indonesia |
title_full_unstemmed |
Comparison of the performance of the CareStart Malaria Pf/Pan Combo test and field microscopy in the diagnosis of Plasmodium vivax malaria in North Sumatera, Indonesia |
title_sort |
comparison of the performance of the carestart malaria pf/pan combo test and field microscopy in the diagnosis of plasmodium vivax malaria in north sumatera, indonesia |
publisher |
BMC |
publishDate |
2022 |
url |
https://doi.org/10.1186/s12936-022-04057-1 https://doaj.org/article/82808481dd0a472e9bc046152456c6c9 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 21, Iss 1, Pp 1-6 (2022) |
op_relation |
https://doi.org/10.1186/s12936-022-04057-1 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-022-04057-1 1475-2875 https://doaj.org/article/82808481dd0a472e9bc046152456c6c9 |
op_doi |
https://doi.org/10.1186/s12936-022-04057-1 |
container_title |
Malaria Journal |
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21 |
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1 |
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1766340893542973440 |