The clinical burden of human cystic echinococcosis in Palestine, 2010-2015.
Cystic echinococcosis (CE) is classified by the WHO as a neglected disease inflicting economic losses on the health systems of many countries worldwide. The aim of this case-series study was to investigate the burden of human CE in Palestine during the period between 2010 and 2015.Records of surgica...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0005717 https://doaj.org/article/825b6473c88441488a0becb615d078a7 |
id |
ftdoajarticles:oai:doaj.org/article:825b6473c88441488a0becb615d078a7 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:825b6473c88441488a0becb615d078a7 2023-05-15T15:16:10+02:00 The clinical burden of human cystic echinococcosis in Palestine, 2010-2015. Amer Al-Jawabreh Suheir Ereqat Kamal Dumaidi Abdelmajeed Nasereddin Hanan Al-Jawabreh Kifaya Azmi Nahed Al-Laham Moath Nairat Adriano Casulli Husni Maqboul Ziad Abdeen 2017-07-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005717 https://doaj.org/article/825b6473c88441488a0becb615d078a7 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5510903?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005717 https://doaj.org/article/825b6473c88441488a0becb615d078a7 PLoS Neglected Tropical Diseases, Vol 11, Iss 7, p e0005717 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005717 2022-12-31T01:09:27Z Cystic echinococcosis (CE) is classified by the WHO as a neglected disease inflicting economic losses on the health systems of many countries worldwide. The aim of this case-series study was to investigate the burden of human CE in Palestine during the period between 2010 and 2015.Records of surgically confirmed CE patients from 13 public and private hospitals in the West Bank and Gaza Strip were reviewed. Patients' cysts were collected from surgical wards and formalin-fixed paraffin-embedded (FFPE) blocks were collected from histopathology departments. Molecular identification of CE species /genotypes was conducted by targeting a repeat DNA sequence (EgG1 Hae III) within Echinococcus nuclear genome and a fragment within the mitochondrial cytochrome c oxidase subunit 1, (CO1). Confirmation of CE species/genotypes was carried out using sequencing followed by BLAST analysis and the construction of maximum likelihood consensus dendrogram. CE cases were map-spotted and statistically significant foci identified by spatial analysis. A total of 353 CE patients were identified in 108 localities from the West Bank and Gaza Strip. The average surgical incidence in the West Bank was 2.1 per 100,000. Spot-mapping and purely spatial analysis showed 13 out of 16 Palestinian districts had cases of CE, of which 9 were in the West Bank and 4 in Gaza Strip. Al-Khalil and Bethlehem were statistically significant foci of CE in Palestine with a six-year average incidence of 4.2 and 3.7 per 100,000, respectively.To the best of our knowledge, this is the first confirmation of human CE causative agent in Palestine. This study revealed that E. granulosus sensu stricto (s.s.) was the predominating species responsible for CE in humans with 11 samples identified as G1 genotype and 2 as G3 genotype. This study emphasizes the need for a stringent surveillance system and risk assessment studies in the rural areas of high incidence as a prerequisite for control measures. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 7 e0005717 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Amer Al-Jawabreh Suheir Ereqat Kamal Dumaidi Abdelmajeed Nasereddin Hanan Al-Jawabreh Kifaya Azmi Nahed Al-Laham Moath Nairat Adriano Casulli Husni Maqboul Ziad Abdeen The clinical burden of human cystic echinococcosis in Palestine, 2010-2015. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Cystic echinococcosis (CE) is classified by the WHO as a neglected disease inflicting economic losses on the health systems of many countries worldwide. The aim of this case-series study was to investigate the burden of human CE in Palestine during the period between 2010 and 2015.Records of surgically confirmed CE patients from 13 public and private hospitals in the West Bank and Gaza Strip were reviewed. Patients' cysts were collected from surgical wards and formalin-fixed paraffin-embedded (FFPE) blocks were collected from histopathology departments. Molecular identification of CE species /genotypes was conducted by targeting a repeat DNA sequence (EgG1 Hae III) within Echinococcus nuclear genome and a fragment within the mitochondrial cytochrome c oxidase subunit 1, (CO1). Confirmation of CE species/genotypes was carried out using sequencing followed by BLAST analysis and the construction of maximum likelihood consensus dendrogram. CE cases were map-spotted and statistically significant foci identified by spatial analysis. A total of 353 CE patients were identified in 108 localities from the West Bank and Gaza Strip. The average surgical incidence in the West Bank was 2.1 per 100,000. Spot-mapping and purely spatial analysis showed 13 out of 16 Palestinian districts had cases of CE, of which 9 were in the West Bank and 4 in Gaza Strip. Al-Khalil and Bethlehem were statistically significant foci of CE in Palestine with a six-year average incidence of 4.2 and 3.7 per 100,000, respectively.To the best of our knowledge, this is the first confirmation of human CE causative agent in Palestine. This study revealed that E. granulosus sensu stricto (s.s.) was the predominating species responsible for CE in humans with 11 samples identified as G1 genotype and 2 as G3 genotype. This study emphasizes the need for a stringent surveillance system and risk assessment studies in the rural areas of high incidence as a prerequisite for control measures. |
format |
Article in Journal/Newspaper |
author |
Amer Al-Jawabreh Suheir Ereqat Kamal Dumaidi Abdelmajeed Nasereddin Hanan Al-Jawabreh Kifaya Azmi Nahed Al-Laham Moath Nairat Adriano Casulli Husni Maqboul Ziad Abdeen |
author_facet |
Amer Al-Jawabreh Suheir Ereqat Kamal Dumaidi Abdelmajeed Nasereddin Hanan Al-Jawabreh Kifaya Azmi Nahed Al-Laham Moath Nairat Adriano Casulli Husni Maqboul Ziad Abdeen |
author_sort |
Amer Al-Jawabreh |
title |
The clinical burden of human cystic echinococcosis in Palestine, 2010-2015. |
title_short |
The clinical burden of human cystic echinococcosis in Palestine, 2010-2015. |
title_full |
The clinical burden of human cystic echinococcosis in Palestine, 2010-2015. |
title_fullStr |
The clinical burden of human cystic echinococcosis in Palestine, 2010-2015. |
title_full_unstemmed |
The clinical burden of human cystic echinococcosis in Palestine, 2010-2015. |
title_sort |
clinical burden of human cystic echinococcosis in palestine, 2010-2015. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005717 https://doaj.org/article/825b6473c88441488a0becb615d078a7 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 7, p e0005717 (2017) |
op_relation |
http://europepmc.org/articles/PMC5510903?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005717 https://doaj.org/article/825b6473c88441488a0becb615d078a7 |
op_doi |
https://doi.org/10.1371/journal.pntd.0005717 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
11 |
container_issue |
7 |
container_start_page |
e0005717 |
_version_ |
1766346464561201152 |