Marine-Derived Bioactive Peptides Self-Assembled Multifunctional Materials: Antioxidant and Wound Healing
Peptide self-assembling materials have received significant attention from researchers in recent years, emerging as a popular field in biological, environmental, medical, and other new materials studies. In this study, we utilized controllable enzymatic hydrolysis technology (animal proteases) to ob...
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ftdoajarticles:oai:doaj.org/article:8205f74db8a948bc929960479dc256f4 2023-07-23T04:18:56+02:00 Marine-Derived Bioactive Peptides Self-Assembled Multifunctional Materials: Antioxidant and Wound Healing Dingyi Yu Shenghao Cui Liqi Chen Shuang Zheng Di Zhao Xinyu Yin Faming Yang Jingdi Chen 2023-05-01T00:00:00Z https://doi.org/10.3390/antiox12061190 https://doaj.org/article/8205f74db8a948bc929960479dc256f4 EN eng MDPI AG https://www.mdpi.com/2076-3921/12/6/1190 https://doaj.org/toc/2076-3921 doi:10.3390/antiox12061190 2076-3921 https://doaj.org/article/8205f74db8a948bc929960479dc256f4 Antioxidants, Vol 12, Iss 1190, p 1190 (2023) marine-derived bioactive peptides self-assembled peptides materials wound healing topical application molecular docking Therapeutics. Pharmacology RM1-950 article 2023 ftdoajarticles https://doi.org/10.3390/antiox12061190 2023-07-02T00:39:09Z Peptide self-assembling materials have received significant attention from researchers in recent years, emerging as a popular field in biological, environmental, medical, and other new materials studies. In this study, we utilized controllable enzymatic hydrolysis technology (animal proteases) to obtain supramolecular peptide self-assembling materials (CAPs) from the Pacific oyster ( Crassostrea gigas ). We conducted physicochemical analyses to explore the pro-healing mechanisms of CAPs on skin wounds in both in vitro and in vivo experiments through a topical application. The results demonstrated that CAPs exhibit a pH-responsive behavior for self-assembly and consist of peptides ranging from 550 to 2300 Da in molecular weight, with peptide chain lengths of mainly 11–16 amino acids. In vitro experiments indicated that CAPs display a procoagulant effect, free radical scavenging activity, and promote the proliferation of HaCaTs (112.74% and 127.61%). Moreover, our in vivo experiments demonstrated that CAPs possess the ability to mitigate inflammation, boost fibroblast proliferation, and promote revascularization, which accelerates the epithelialization process. Consequently, a balanced collagen I/III ratio in the repaired tissue and the promotion of hair follicle regeneration were observed. With these remarkable findings, CAPs can be regarded as a natural and secure treatment option with high efficacy for skin wound healing. The potential of CAPs to be further developed for traceless skin wound healing is an exciting area for future research and development. Article in Journal/Newspaper Crassostrea gigas Pacific oyster Directory of Open Access Journals: DOAJ Articles Pacific Antioxidants 12 6 1190 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
marine-derived bioactive peptides self-assembled peptides materials wound healing topical application molecular docking Therapeutics. Pharmacology RM1-950 |
spellingShingle |
marine-derived bioactive peptides self-assembled peptides materials wound healing topical application molecular docking Therapeutics. Pharmacology RM1-950 Dingyi Yu Shenghao Cui Liqi Chen Shuang Zheng Di Zhao Xinyu Yin Faming Yang Jingdi Chen Marine-Derived Bioactive Peptides Self-Assembled Multifunctional Materials: Antioxidant and Wound Healing |
topic_facet |
marine-derived bioactive peptides self-assembled peptides materials wound healing topical application molecular docking Therapeutics. Pharmacology RM1-950 |
description |
Peptide self-assembling materials have received significant attention from researchers in recent years, emerging as a popular field in biological, environmental, medical, and other new materials studies. In this study, we utilized controllable enzymatic hydrolysis technology (animal proteases) to obtain supramolecular peptide self-assembling materials (CAPs) from the Pacific oyster ( Crassostrea gigas ). We conducted physicochemical analyses to explore the pro-healing mechanisms of CAPs on skin wounds in both in vitro and in vivo experiments through a topical application. The results demonstrated that CAPs exhibit a pH-responsive behavior for self-assembly and consist of peptides ranging from 550 to 2300 Da in molecular weight, with peptide chain lengths of mainly 11–16 amino acids. In vitro experiments indicated that CAPs display a procoagulant effect, free radical scavenging activity, and promote the proliferation of HaCaTs (112.74% and 127.61%). Moreover, our in vivo experiments demonstrated that CAPs possess the ability to mitigate inflammation, boost fibroblast proliferation, and promote revascularization, which accelerates the epithelialization process. Consequently, a balanced collagen I/III ratio in the repaired tissue and the promotion of hair follicle regeneration were observed. With these remarkable findings, CAPs can be regarded as a natural and secure treatment option with high efficacy for skin wound healing. The potential of CAPs to be further developed for traceless skin wound healing is an exciting area for future research and development. |
format |
Article in Journal/Newspaper |
author |
Dingyi Yu Shenghao Cui Liqi Chen Shuang Zheng Di Zhao Xinyu Yin Faming Yang Jingdi Chen |
author_facet |
Dingyi Yu Shenghao Cui Liqi Chen Shuang Zheng Di Zhao Xinyu Yin Faming Yang Jingdi Chen |
author_sort |
Dingyi Yu |
title |
Marine-Derived Bioactive Peptides Self-Assembled Multifunctional Materials: Antioxidant and Wound Healing |
title_short |
Marine-Derived Bioactive Peptides Self-Assembled Multifunctional Materials: Antioxidant and Wound Healing |
title_full |
Marine-Derived Bioactive Peptides Self-Assembled Multifunctional Materials: Antioxidant and Wound Healing |
title_fullStr |
Marine-Derived Bioactive Peptides Self-Assembled Multifunctional Materials: Antioxidant and Wound Healing |
title_full_unstemmed |
Marine-Derived Bioactive Peptides Self-Assembled Multifunctional Materials: Antioxidant and Wound Healing |
title_sort |
marine-derived bioactive peptides self-assembled multifunctional materials: antioxidant and wound healing |
publisher |
MDPI AG |
publishDate |
2023 |
url |
https://doi.org/10.3390/antiox12061190 https://doaj.org/article/8205f74db8a948bc929960479dc256f4 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
Antioxidants, Vol 12, Iss 1190, p 1190 (2023) |
op_relation |
https://www.mdpi.com/2076-3921/12/6/1190 https://doaj.org/toc/2076-3921 doi:10.3390/antiox12061190 2076-3921 https://doaj.org/article/8205f74db8a948bc929960479dc256f4 |
op_doi |
https://doi.org/10.3390/antiox12061190 |
container_title |
Antioxidants |
container_volume |
12 |
container_issue |
6 |
container_start_page |
1190 |
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1772181658545422336 |