Unique heterologous fibrin biopolymer with hemostatic, adhesive, sealant, scaffold and drug delivery properties: a systematic review
Abstract Fibrin biopolymers, previously referred as “fibrin glue” or “fibrin sealants”, are natural biomaterials with diverse applications on health. They have hemostatic, adhesive, sealant, scaffold and drug delivery properties and have become widely used in medical and dental procedures. Historica...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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Online Access: | https://doi.org/10.1590/1678-9199-jvatitd-2019-0038 https://doaj.org/article/81a4749171754ce3b9efddaf4ac4d813 |
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ftdoajarticles:oai:doaj.org/article:81a4749171754ce3b9efddaf4ac4d813 2023-05-15T15:12:56+02:00 Unique heterologous fibrin biopolymer with hemostatic, adhesive, sealant, scaffold and drug delivery properties: a systematic review Daniela Vieira Buchaim Claudia Vilalva Cassaro João Vitor Tadashi Cosin Shindo Bruna Botteon Della Coletta Karina Torres Pomini Marcelie Priscila de Oliveira Rosso Leila Maria Guissoni Campos Rui Seabra Ferreira Jr Benedito Barraviera Rogério Leone Buchaim 2019-11-01T00:00:00Z https://doi.org/10.1590/1678-9199-jvatitd-2019-0038 https://doaj.org/article/81a4749171754ce3b9efddaf4ac4d813 EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100207&tlng=en http://www.scielo.br/pdf/jvatitd/v25/1678-4936-jvatitd-25-e20190038.pdf https://doaj.org/toc/1678-9199 1678-9199 doi:10.1590/1678-9199-jvatitd-2019-0038 https://doaj.org/article/81a4749171754ce3b9efddaf4ac4d813 Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 25 (2019) Fibrin sealant Snake venom Thrombin-like enzyme Cryoprecipitate coagulum Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2019 ftdoajarticles https://doi.org/10.1590/1678-9199-jvatitd-2019-0038 2022-12-31T14:36:18Z Abstract Fibrin biopolymers, previously referred as “fibrin glue” or “fibrin sealants”, are natural biomaterials with diverse applications on health. They have hemostatic, adhesive, sealant, scaffold and drug delivery properties and have become widely used in medical and dental procedures. Historically, these biomaterials are produced from human fibrinogen and human or animal thrombin, and the possibility of transmission of infectious diseases by human blood is not ruled out. In the 1990s, to overcome this problem, a new heterologous biomaterial composed of a thrombin-like enzyme purified from Crotalus durissus terrificus venom and a cryoprecipitate rich in fibrinogen extracted from buffaloes Bubalus bubalis blood has been proposed. Therefore, a systematic review of studies on exclusively heterologous fibrin sealants published between 1989 and 2018 was carried out using the following databases: PubMed, SciELO and Google Scholar. The keyword used was “heterologous fibrin sealant”. The search resulted in 35 scientific papers in PubMed, four in SciELO and 674 in Google Scholar. After applying the inclusion/exclusion criteria and complete reading of the articles, 30 studies were selected, which formed the basis of this systematic review. It has been observed that the only completely heterologous sealant is the one produced by CEVAP/UNESP. This heterologous biopolymer is proven effective by several studies published in refereed scientific journals. In addition, clinical trials phase I/II for the treatment of chronic venous ulcers authorized by the Brazilian Health Regulatory Agency (ANVISA) were completed. Preliminary results have indicated a safe and promising effective product. Phase III clinical trials will be proposed and required to validate these preliminary findings. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 25 |
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collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Fibrin sealant Snake venom Thrombin-like enzyme Cryoprecipitate coagulum Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Fibrin sealant Snake venom Thrombin-like enzyme Cryoprecipitate coagulum Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 Daniela Vieira Buchaim Claudia Vilalva Cassaro João Vitor Tadashi Cosin Shindo Bruna Botteon Della Coletta Karina Torres Pomini Marcelie Priscila de Oliveira Rosso Leila Maria Guissoni Campos Rui Seabra Ferreira Jr Benedito Barraviera Rogério Leone Buchaim Unique heterologous fibrin biopolymer with hemostatic, adhesive, sealant, scaffold and drug delivery properties: a systematic review |
topic_facet |
Fibrin sealant Snake venom Thrombin-like enzyme Cryoprecipitate coagulum Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Abstract Fibrin biopolymers, previously referred as “fibrin glue” or “fibrin sealants”, are natural biomaterials with diverse applications on health. They have hemostatic, adhesive, sealant, scaffold and drug delivery properties and have become widely used in medical and dental procedures. Historically, these biomaterials are produced from human fibrinogen and human or animal thrombin, and the possibility of transmission of infectious diseases by human blood is not ruled out. In the 1990s, to overcome this problem, a new heterologous biomaterial composed of a thrombin-like enzyme purified from Crotalus durissus terrificus venom and a cryoprecipitate rich in fibrinogen extracted from buffaloes Bubalus bubalis blood has been proposed. Therefore, a systematic review of studies on exclusively heterologous fibrin sealants published between 1989 and 2018 was carried out using the following databases: PubMed, SciELO and Google Scholar. The keyword used was “heterologous fibrin sealant”. The search resulted in 35 scientific papers in PubMed, four in SciELO and 674 in Google Scholar. After applying the inclusion/exclusion criteria and complete reading of the articles, 30 studies were selected, which formed the basis of this systematic review. It has been observed that the only completely heterologous sealant is the one produced by CEVAP/UNESP. This heterologous biopolymer is proven effective by several studies published in refereed scientific journals. In addition, clinical trials phase I/II for the treatment of chronic venous ulcers authorized by the Brazilian Health Regulatory Agency (ANVISA) were completed. Preliminary results have indicated a safe and promising effective product. Phase III clinical trials will be proposed and required to validate these preliminary findings. |
format |
Article in Journal/Newspaper |
author |
Daniela Vieira Buchaim Claudia Vilalva Cassaro João Vitor Tadashi Cosin Shindo Bruna Botteon Della Coletta Karina Torres Pomini Marcelie Priscila de Oliveira Rosso Leila Maria Guissoni Campos Rui Seabra Ferreira Jr Benedito Barraviera Rogério Leone Buchaim |
author_facet |
Daniela Vieira Buchaim Claudia Vilalva Cassaro João Vitor Tadashi Cosin Shindo Bruna Botteon Della Coletta Karina Torres Pomini Marcelie Priscila de Oliveira Rosso Leila Maria Guissoni Campos Rui Seabra Ferreira Jr Benedito Barraviera Rogério Leone Buchaim |
author_sort |
Daniela Vieira Buchaim |
title |
Unique heterologous fibrin biopolymer with hemostatic, adhesive, sealant, scaffold and drug delivery properties: a systematic review |
title_short |
Unique heterologous fibrin biopolymer with hemostatic, adhesive, sealant, scaffold and drug delivery properties: a systematic review |
title_full |
Unique heterologous fibrin biopolymer with hemostatic, adhesive, sealant, scaffold and drug delivery properties: a systematic review |
title_fullStr |
Unique heterologous fibrin biopolymer with hemostatic, adhesive, sealant, scaffold and drug delivery properties: a systematic review |
title_full_unstemmed |
Unique heterologous fibrin biopolymer with hemostatic, adhesive, sealant, scaffold and drug delivery properties: a systematic review |
title_sort |
unique heterologous fibrin biopolymer with hemostatic, adhesive, sealant, scaffold and drug delivery properties: a systematic review |
publisher |
SciELO |
publishDate |
2019 |
url |
https://doi.org/10.1590/1678-9199-jvatitd-2019-0038 https://doaj.org/article/81a4749171754ce3b9efddaf4ac4d813 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 25 (2019) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100207&tlng=en http://www.scielo.br/pdf/jvatitd/v25/1678-4936-jvatitd-25-e20190038.pdf https://doaj.org/toc/1678-9199 1678-9199 doi:10.1590/1678-9199-jvatitd-2019-0038 https://doaj.org/article/81a4749171754ce3b9efddaf4ac4d813 |
op_doi |
https://doi.org/10.1590/1678-9199-jvatitd-2019-0038 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
25 |
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1766343556815912960 |