Dual Analysis of Virus-Host Interactions: The Case of 1 and the Cupped Oyster
Dual analyses of the interactions between Ostreid herpesvirus 1 (OsHV-1) and the bivalve Crassostrea gigas during infection can unveil events critical to the onset and progression of this viral disease and can provide novel strategies for mitigating and preventing oyster mortality. Among the current...
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ftdoajarticles:oai:doaj.org/article:817a82706296455ebc182551466cabb5 2023-05-15T15:58:38+02:00 Dual Analysis of Virus-Host Interactions: The Case of 1 and the Cupped Oyster Umberto Rosani Tim Young Chang-Ming Bai Andrea C. Alfaro Paola Venier 2019-02-01T00:00:00Z https://doi.org/10.1177/1176934319831305 https://doaj.org/article/817a82706296455ebc182551466cabb5 EN eng SAGE Publishing https://doi.org/10.1177/1176934319831305 https://doaj.org/toc/1176-9343 1176-9343 doi:10.1177/1176934319831305 https://doaj.org/article/817a82706296455ebc182551466cabb5 Evolutionary Bioinformatics, Vol 15 (2019) Evolution QH359-425 article 2019 ftdoajarticles https://doi.org/10.1177/1176934319831305 2022-12-31T09:12:22Z Dual analyses of the interactions between Ostreid herpesvirus 1 (OsHV-1) and the bivalve Crassostrea gigas during infection can unveil events critical to the onset and progression of this viral disease and can provide novel strategies for mitigating and preventing oyster mortality. Among the currently used “omics” technologies, dual transcriptomics (dual RNA-seq) coupled with the analysis of viral DNA in the host tissues has greatly advanced the knowledge of genes and pathways mostly contributing to host defense responses, expression profiles of annotated and unknown OsHV-1 open reading frames (ORFs), and viral genome variability. In addition to dual RNA-seq, proteomics and metabolomics analyses have the potential to add complementary information, needed to understand how a malacoherpesvirus can redirect and exploit the vital processes of its host. This review explores our current knowledge of “omics” technologies in the study of host-pathogen interactions and highlights relevant applications of these fields of expertise to the complex case of C gigas infections by OsHV-1, which currently threaten the mollusk production sector worldwide. Article in Journal/Newspaper Crassostrea gigas Directory of Open Access Journals: DOAJ Articles Evolutionary Bioinformatics 15 117693431983130 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Evolution QH359-425 |
spellingShingle |
Evolution QH359-425 Umberto Rosani Tim Young Chang-Ming Bai Andrea C. Alfaro Paola Venier Dual Analysis of Virus-Host Interactions: The Case of 1 and the Cupped Oyster |
topic_facet |
Evolution QH359-425 |
description |
Dual analyses of the interactions between Ostreid herpesvirus 1 (OsHV-1) and the bivalve Crassostrea gigas during infection can unveil events critical to the onset and progression of this viral disease and can provide novel strategies for mitigating and preventing oyster mortality. Among the currently used “omics” technologies, dual transcriptomics (dual RNA-seq) coupled with the analysis of viral DNA in the host tissues has greatly advanced the knowledge of genes and pathways mostly contributing to host defense responses, expression profiles of annotated and unknown OsHV-1 open reading frames (ORFs), and viral genome variability. In addition to dual RNA-seq, proteomics and metabolomics analyses have the potential to add complementary information, needed to understand how a malacoherpesvirus can redirect and exploit the vital processes of its host. This review explores our current knowledge of “omics” technologies in the study of host-pathogen interactions and highlights relevant applications of these fields of expertise to the complex case of C gigas infections by OsHV-1, which currently threaten the mollusk production sector worldwide. |
format |
Article in Journal/Newspaper |
author |
Umberto Rosani Tim Young Chang-Ming Bai Andrea C. Alfaro Paola Venier |
author_facet |
Umberto Rosani Tim Young Chang-Ming Bai Andrea C. Alfaro Paola Venier |
author_sort |
Umberto Rosani |
title |
Dual Analysis of Virus-Host Interactions: The Case of 1 and the Cupped Oyster |
title_short |
Dual Analysis of Virus-Host Interactions: The Case of 1 and the Cupped Oyster |
title_full |
Dual Analysis of Virus-Host Interactions: The Case of 1 and the Cupped Oyster |
title_fullStr |
Dual Analysis of Virus-Host Interactions: The Case of 1 and the Cupped Oyster |
title_full_unstemmed |
Dual Analysis of Virus-Host Interactions: The Case of 1 and the Cupped Oyster |
title_sort |
dual analysis of virus-host interactions: the case of 1 and the cupped oyster |
publisher |
SAGE Publishing |
publishDate |
2019 |
url |
https://doi.org/10.1177/1176934319831305 https://doaj.org/article/817a82706296455ebc182551466cabb5 |
genre |
Crassostrea gigas |
genre_facet |
Crassostrea gigas |
op_source |
Evolutionary Bioinformatics, Vol 15 (2019) |
op_relation |
https://doi.org/10.1177/1176934319831305 https://doaj.org/toc/1176-9343 1176-9343 doi:10.1177/1176934319831305 https://doaj.org/article/817a82706296455ebc182551466cabb5 |
op_doi |
https://doi.org/10.1177/1176934319831305 |
container_title |
Evolutionary Bioinformatics |
container_volume |
15 |
container_start_page |
117693431983130 |
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1766394401558364160 |