Prevalence of hepatitis B virus infection and carriage after nineteen years of vaccination program in the Western Brazilian Amazon
INTRODUCTION: Reductions in the prevalence of hepatitis B virus (HBV) infection and carriage, decreases in liver cancer incidence, and changes in patterns of liver dysfunctions are described after hepatitis B vaccination. METHODS: We conducted a population-based seroprevalence study aimed at estimat...
Published in: | Revista da Sociedade Brasileira de Medicina Tropical |
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Online Access: | https://doi.org/10.1590/S0037-86822012000100004 https://doaj.org/article/81707c08c5f64649a00bf89c018f432a |
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ftdoajarticles:oai:doaj.org/article:81707c08c5f64649a00bf89c018f432a 2023-05-15T15:09:47+02:00 Prevalence of hepatitis B virus infection and carriage after nineteen years of vaccination program in the Western Brazilian Amazon Wornei Silva Miranda Braga Márcia da Costa Castilho Fabiane Giovanella Borges Ana Cristina de Souza Martinho Ivo Seixas Rodrigues Eliete Pereira de Azevedo Márcia Scazufca Paulo Rossi Menezes 2012-02-01T00:00:00Z https://doi.org/10.1590/S0037-86822012000100004 https://doaj.org/article/81707c08c5f64649a00bf89c018f432a EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000100004&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86822012000100004 https://doaj.org/article/81707c08c5f64649a00bf89c018f432a Revista da Sociedade Brasileira de Medicina Tropical, Vol 45, Iss 1, Pp 13-17 (2012) HBV Hepatite B Prevalência Vacinação Epidemiologia Arctic medicine. Tropical medicine RC955-962 article 2012 ftdoajarticles https://doi.org/10.1590/S0037-86822012000100004 2022-12-31T02:02:45Z INTRODUCTION: Reductions in the prevalence of hepatitis B virus (HBV) infection and carriage, decreases in liver cancer incidence, and changes in patterns of liver dysfunctions are described after hepatitis B vaccination. METHODS: We conducted a population-based seroprevalence study aimed at estimating the HBV prevalence and risk of infection in the rural area of Lábrea following nineteen years of HBV vaccination. RESULTS: Half of the subjects showed total anti-HBc of 52.1% (95% CI 49.6-54.7). The HBsAg prevalence was 6.2% (95% CI 5.1-7.6). Multivariate analysis showed an inverse association between HBV infection and vaccination (OR 0.62; 95% CI 0.44-0.87). HBsAg remained independently associated with past hepatitis (OR 2.44; 95% CI 1.52-3.89) and inversely to vaccination (OR 0.43; 95% CI 0.27-0.69). The prevalence of HBeAg among HBsAg-positive individuals was 20.4% (95% CI 12.8-30.1), with the positive subjects having a median age of 11 years (1-46) p=0.0003. CONCLUSIONS: We demonstrate that HBV infection is still an important public health issue and that HBV vaccination could have had better impact on HBV epidemiology. If we extrapolate these findings to other rural areas in the Brazilian Amazon, we can predict that the sources of chronic infected patients remain a challenge. Future studies are needed regarding clinical aspects, molecular epidemiology, surveillance of acute cases, and risk groups. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 45 1 13 17 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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HBV Hepatite B Prevalência Vacinação Epidemiologia Arctic medicine. Tropical medicine RC955-962 |
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HBV Hepatite B Prevalência Vacinação Epidemiologia Arctic medicine. Tropical medicine RC955-962 Wornei Silva Miranda Braga Márcia da Costa Castilho Fabiane Giovanella Borges Ana Cristina de Souza Martinho Ivo Seixas Rodrigues Eliete Pereira de Azevedo Márcia Scazufca Paulo Rossi Menezes Prevalence of hepatitis B virus infection and carriage after nineteen years of vaccination program in the Western Brazilian Amazon |
topic_facet |
HBV Hepatite B Prevalência Vacinação Epidemiologia Arctic medicine. Tropical medicine RC955-962 |
description |
INTRODUCTION: Reductions in the prevalence of hepatitis B virus (HBV) infection and carriage, decreases in liver cancer incidence, and changes in patterns of liver dysfunctions are described after hepatitis B vaccination. METHODS: We conducted a population-based seroprevalence study aimed at estimating the HBV prevalence and risk of infection in the rural area of Lábrea following nineteen years of HBV vaccination. RESULTS: Half of the subjects showed total anti-HBc of 52.1% (95% CI 49.6-54.7). The HBsAg prevalence was 6.2% (95% CI 5.1-7.6). Multivariate analysis showed an inverse association between HBV infection and vaccination (OR 0.62; 95% CI 0.44-0.87). HBsAg remained independently associated with past hepatitis (OR 2.44; 95% CI 1.52-3.89) and inversely to vaccination (OR 0.43; 95% CI 0.27-0.69). The prevalence of HBeAg among HBsAg-positive individuals was 20.4% (95% CI 12.8-30.1), with the positive subjects having a median age of 11 years (1-46) p=0.0003. CONCLUSIONS: We demonstrate that HBV infection is still an important public health issue and that HBV vaccination could have had better impact on HBV epidemiology. If we extrapolate these findings to other rural areas in the Brazilian Amazon, we can predict that the sources of chronic infected patients remain a challenge. Future studies are needed regarding clinical aspects, molecular epidemiology, surveillance of acute cases, and risk groups. |
format |
Article in Journal/Newspaper |
author |
Wornei Silva Miranda Braga Márcia da Costa Castilho Fabiane Giovanella Borges Ana Cristina de Souza Martinho Ivo Seixas Rodrigues Eliete Pereira de Azevedo Márcia Scazufca Paulo Rossi Menezes |
author_facet |
Wornei Silva Miranda Braga Márcia da Costa Castilho Fabiane Giovanella Borges Ana Cristina de Souza Martinho Ivo Seixas Rodrigues Eliete Pereira de Azevedo Márcia Scazufca Paulo Rossi Menezes |
author_sort |
Wornei Silva Miranda Braga |
title |
Prevalence of hepatitis B virus infection and carriage after nineteen years of vaccination program in the Western Brazilian Amazon |
title_short |
Prevalence of hepatitis B virus infection and carriage after nineteen years of vaccination program in the Western Brazilian Amazon |
title_full |
Prevalence of hepatitis B virus infection and carriage after nineteen years of vaccination program in the Western Brazilian Amazon |
title_fullStr |
Prevalence of hepatitis B virus infection and carriage after nineteen years of vaccination program in the Western Brazilian Amazon |
title_full_unstemmed |
Prevalence of hepatitis B virus infection and carriage after nineteen years of vaccination program in the Western Brazilian Amazon |
title_sort |
prevalence of hepatitis b virus infection and carriage after nineteen years of vaccination program in the western brazilian amazon |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2012 |
url |
https://doi.org/10.1590/S0037-86822012000100004 https://doaj.org/article/81707c08c5f64649a00bf89c018f432a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 45, Iss 1, Pp 13-17 (2012) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000100004&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86822012000100004 https://doaj.org/article/81707c08c5f64649a00bf89c018f432a |
op_doi |
https://doi.org/10.1590/S0037-86822012000100004 |
container_title |
Revista da Sociedade Brasileira de Medicina Tropical |
container_volume |
45 |
container_issue |
1 |
container_start_page |
13 |
op_container_end_page |
17 |
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1766340906304143360 |