Chikungunya disease: infection-associated markers from the acute to the chronic phase of arbovirus-induced arthralgia.
At the end of 2005, an outbreak of fever associated with joint pain occurred in La Réunion. The causal agent, chikungunya virus (CHIKV), has been known for 50 years and could thus be readily identified. This arbovirus is present worldwide, particularly in India, but also in Europe, with new variants...
Published in: | PLoS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0001446 https://doaj.org/article/80faeeff973d4ee2bd03eed373812fb6 |
id |
ftdoajarticles:oai:doaj.org/article:80faeeff973d4ee2bd03eed373812fb6 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:80faeeff973d4ee2bd03eed373812fb6 2023-05-15T15:05:30+02:00 Chikungunya disease: infection-associated markers from the acute to the chronic phase of arbovirus-induced arthralgia. Laurence Dupuis-Maguiraga Marion Noret Sonia Brun Roger Le Grand Gabriel Gras Pierre Roques 2012-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001446 https://doaj.org/article/80faeeff973d4ee2bd03eed373812fb6 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3313943?pdf=render https://doaj.org/toc/1935-2735 1935-2735 doi:10.1371/journal.pntd.0001446 https://doaj.org/article/80faeeff973d4ee2bd03eed373812fb6 PLoS Neglected Tropical Diseases, Vol 6, Iss 3, p e1446 (2012) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2012 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001446 2022-12-31T07:25:35Z At the end of 2005, an outbreak of fever associated with joint pain occurred in La Réunion. The causal agent, chikungunya virus (CHIKV), has been known for 50 years and could thus be readily identified. This arbovirus is present worldwide, particularly in India, but also in Europe, with new variants returning to Africa. In humans, it causes a disease characterized by a typical acute infection, sometimes followed by persistent arthralgia and myalgia lasting months or years. Investigations in the La Réunion cohort and studies in a macaque model of chikungunya implicated monocytes-macrophages in viral persistence. In this Review, we consider the relationship between CHIKV and the immune response and discuss predictive factors for chronic arthralgia and myalgia by providing an overview of current knowledge on chikungunya pathogenesis. Comparisons of data from animal models of the acute and chronic phases of infection, and data from clinical series, provide information about the mechanisms of CHIKV infection-associated inflammation, viral persistence in monocytes-macrophages, and their link to chronic signs. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 6 3 e1446 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Laurence Dupuis-Maguiraga Marion Noret Sonia Brun Roger Le Grand Gabriel Gras Pierre Roques Chikungunya disease: infection-associated markers from the acute to the chronic phase of arbovirus-induced arthralgia. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
At the end of 2005, an outbreak of fever associated with joint pain occurred in La Réunion. The causal agent, chikungunya virus (CHIKV), has been known for 50 years and could thus be readily identified. This arbovirus is present worldwide, particularly in India, but also in Europe, with new variants returning to Africa. In humans, it causes a disease characterized by a typical acute infection, sometimes followed by persistent arthralgia and myalgia lasting months or years. Investigations in the La Réunion cohort and studies in a macaque model of chikungunya implicated monocytes-macrophages in viral persistence. In this Review, we consider the relationship between CHIKV and the immune response and discuss predictive factors for chronic arthralgia and myalgia by providing an overview of current knowledge on chikungunya pathogenesis. Comparisons of data from animal models of the acute and chronic phases of infection, and data from clinical series, provide information about the mechanisms of CHIKV infection-associated inflammation, viral persistence in monocytes-macrophages, and their link to chronic signs. |
format |
Article in Journal/Newspaper |
author |
Laurence Dupuis-Maguiraga Marion Noret Sonia Brun Roger Le Grand Gabriel Gras Pierre Roques |
author_facet |
Laurence Dupuis-Maguiraga Marion Noret Sonia Brun Roger Le Grand Gabriel Gras Pierre Roques |
author_sort |
Laurence Dupuis-Maguiraga |
title |
Chikungunya disease: infection-associated markers from the acute to the chronic phase of arbovirus-induced arthralgia. |
title_short |
Chikungunya disease: infection-associated markers from the acute to the chronic phase of arbovirus-induced arthralgia. |
title_full |
Chikungunya disease: infection-associated markers from the acute to the chronic phase of arbovirus-induced arthralgia. |
title_fullStr |
Chikungunya disease: infection-associated markers from the acute to the chronic phase of arbovirus-induced arthralgia. |
title_full_unstemmed |
Chikungunya disease: infection-associated markers from the acute to the chronic phase of arbovirus-induced arthralgia. |
title_sort |
chikungunya disease: infection-associated markers from the acute to the chronic phase of arbovirus-induced arthralgia. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2012 |
url |
https://doi.org/10.1371/journal.pntd.0001446 https://doaj.org/article/80faeeff973d4ee2bd03eed373812fb6 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 6, Iss 3, p e1446 (2012) |
op_relation |
http://europepmc.org/articles/PMC3313943?pdf=render https://doaj.org/toc/1935-2735 1935-2735 doi:10.1371/journal.pntd.0001446 https://doaj.org/article/80faeeff973d4ee2bd03eed373812fb6 |
op_doi |
https://doi.org/10.1371/journal.pntd.0001446 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
6 |
container_issue |
3 |
container_start_page |
e1446 |
_version_ |
1766337197950107648 |