Use of Cavia porcellus (guinea pigs) as an experimental model for Leishmania (Viannia) braziliensis

Laboratory animals are fundamental to study immunological aspects and the efficacy of new drugs to treat leishmaniasis. However, we do not have practical and good animal models to study leishmaniasis caused by Leishmania (Viannia) braziliensis - L(V)b. In this study, thirty-two experimental animals...

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Bibliographic Details
Published in:Journal of Venomous Animals and Toxins including Tropical Diseases
Main Authors: C. D. R. Paula, H. Friedman, R. N. R. Sampaio
Format: Article in Journal/Newspaper
Language:English
Published: SciELO 2005
Subjects:
experimental leishmaniasis
Cavia
animal model
American leishmaniasis
pathogenesis
Arctic medicine. Tropical medicine
RC955-962
Toxicology. Poisons
RA1190-1270
Zoology
QL1-991
Arctic
Online Access:https://doi.org/10.1590/S1678-91992005000400017
https://doaj.org/article/80d3420ae7e240f0a1ea269e34a82011
Description
Summary:Laboratory animals are fundamental to study immunological aspects and the efficacy of new drugs to treat leishmaniasis. However, we do not have practical and good animal models to study leishmaniasis caused by Leishmania (Viannia) braziliensis - L(V)b. In this study, thirty-two experimental animals (Cavia porcellus) were injected in the hind foot with 3x10(5) promastigote forms of L(V)b. The animals were followed for eight weeks. None of the experimental animals developed lesions or presented the parasite in any of the tests performed (histopathological exam, smears, culture, inoculation in hamsters, and polymerase chain reaction).

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