Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome.
The ongoing Zika virus epidemic in the Americas and the observed association with both fetal abnormalities (primary microcephaly) and adult autoimmune pathology (Guillain-Barré syndrome) has brought attention to this neglected pathogen. While initial case studies generated significant interest in th...
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ftdoajarticles:oai:doaj.org/article:80d036de51064e619b6ee75f8ecc7bb3 2023-05-15T15:02:48+02:00 Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome. Zachary A Klase Svetlana Khakhina Adriano De Bernardi Schneider Michael V Callahan Jill Glasspool-Malone Robert Malone 2016-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004877 https://doaj.org/article/80d036de51064e619b6ee75f8ecc7bb3 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4999274?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004877 https://doaj.org/article/80d036de51064e619b6ee75f8ecc7bb3 PLoS Neglected Tropical Diseases, Vol 10, Iss 8, p e0004877 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004877 2022-12-31T03:38:42Z The ongoing Zika virus epidemic in the Americas and the observed association with both fetal abnormalities (primary microcephaly) and adult autoimmune pathology (Guillain-Barré syndrome) has brought attention to this neglected pathogen. While initial case studies generated significant interest in the Zika virus outbreak, larger prospective epidemiology and basic virology studies examining the mechanisms of Zika viral infection and associated pathophysiology are only now starting to be published. In this review, we analyze Zika fetal neuropathogenesis from a comparative pathology perspective, using the historic metaphor of "TORCH" viral pathogenesis to provide context. By drawing parallels to other viral infections of the fetus, we identify common themes and mechanisms that may illuminate the observed pathology. The existing data on the susceptibility of various cells to both Zika and other flavivirus infections are summarized. Finally, we highlight relevant aspects of the known molecular mechanisms of flavivirus replication. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Barré ENVELOPE(-68.550,-68.550,-67.500,-67.500) PLOS Neglected Tropical Diseases 10 8 e0004877 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Zachary A Klase Svetlana Khakhina Adriano De Bernardi Schneider Michael V Callahan Jill Glasspool-Malone Robert Malone Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The ongoing Zika virus epidemic in the Americas and the observed association with both fetal abnormalities (primary microcephaly) and adult autoimmune pathology (Guillain-Barré syndrome) has brought attention to this neglected pathogen. While initial case studies generated significant interest in the Zika virus outbreak, larger prospective epidemiology and basic virology studies examining the mechanisms of Zika viral infection and associated pathophysiology are only now starting to be published. In this review, we analyze Zika fetal neuropathogenesis from a comparative pathology perspective, using the historic metaphor of "TORCH" viral pathogenesis to provide context. By drawing parallels to other viral infections of the fetus, we identify common themes and mechanisms that may illuminate the observed pathology. The existing data on the susceptibility of various cells to both Zika and other flavivirus infections are summarized. Finally, we highlight relevant aspects of the known molecular mechanisms of flavivirus replication. |
format |
Article in Journal/Newspaper |
author |
Zachary A Klase Svetlana Khakhina Adriano De Bernardi Schneider Michael V Callahan Jill Glasspool-Malone Robert Malone |
author_facet |
Zachary A Klase Svetlana Khakhina Adriano De Bernardi Schneider Michael V Callahan Jill Glasspool-Malone Robert Malone |
author_sort |
Zachary A Klase |
title |
Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome. |
title_short |
Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome. |
title_full |
Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome. |
title_fullStr |
Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome. |
title_full_unstemmed |
Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome. |
title_sort |
zika fetal neuropathogenesis: etiology of a viral syndrome. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0004877 https://doaj.org/article/80d036de51064e619b6ee75f8ecc7bb3 |
long_lat |
ENVELOPE(-68.550,-68.550,-67.500,-67.500) |
geographic |
Arctic Barré |
geographic_facet |
Arctic Barré |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 8, p e0004877 (2016) |
op_relation |
http://europepmc.org/articles/PMC4999274?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004877 https://doaj.org/article/80d036de51064e619b6ee75f8ecc7bb3 |
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https://doi.org/10.1371/journal.pntd.0004877 |
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PLOS Neglected Tropical Diseases |
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10 |
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8 |
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e0004877 |
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